研究发现夫妻免疫系统逐渐趋同
http://www.bio360.net/attachments/2016/02/1455947619c5e16a696f329827.jpg当你处于一段关系中时,有可能和另一半共享睡眠习惯、饮食和健身计划。如今,研究发现,当你们生活在一起时,免疫系统看上去也在趋同。相关成果日前发表于《自然—免疫学》杂志。
每个人的免疫系统都是独特的,免疫细胞的数量和类型及其激活状态均不相同。这种多样性便是相同的流感病毒能让一个人仅生病一下午,却让其他人卧床数日的原因所在。
来自比利时天主教鲁汶大学的Adrian Liston和同事研究了年龄在2~86岁的670名健康人的血液样本。对于每个人来说,该团队计数了54种不同激活状态下每一种含有的免疫细胞数。随后,他们进一步分析了四分之一志愿者在6个月内的样本。
研究发现,免疫状况非常稳定。即便是受到干扰,它们也会回到类似的基线状态。当人们患上肠胃炎或注射流感疫苗时,他们的免疫系统在回归正常前仅出现了短暂的扰乱。
Liston还发现了一种有趣的模式:对于生活在一起的人来说,其免疫系统看上去非常相似。“差异性减少了50%。这是一种极其深刻的影响。”Liston表示,“这比你在40年的变老中经历的影响还要大。”
交往中的人们往往采用相似的饮食和生活风格。比如,对于一个滴酒不沾的人来说,其另一半有可能也变得少喝酒。Liston认为,一对夫妻共同生活的某些环境可能是其免疫系统走向趋同的起因。
来源:中国科学报
The cellular composition of the human immune system is shaped by age and cohabitation
Edward J Carr, James Dooley, Josselyn E Garcia-Perez, Vasiliki Lagou, James C Lee, Carine Wouters, Isabelle Meyts, An Goris, Guy Boeckxstaens, Michelle A Linterman & Adrian Liston
Detailed population-level description of the human immune system has recently become achievable. We used a 'systems-level' approach to establish a resource of cellular immune profiles of 670 healthy individuals. We report a high level of interindividual variation, with low longitudinal variation, at the level of cellular subset composition of the immune system. Despite the profound effects of antigen exposure on individual antigen-specific clones, the cellular subset structure proved highly elastic, with transient vaccination-induced changes followed by a return to the individual's unique baseline. Notably, the largest influence on immunological variation identified was cohabitation, with 50% less immunological variation between individuals who share an environment (as parents) than between people in the wider population. These results identify local environmental conditions as a key factor in shaping the human immune system.
http://www.nature.com/ni/journal/vaop/ncurrent/full/ni.3371.html
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