用病毒对抗感染
http://cache1.bioon.com/tm/UploadFiles/201603/2016030622253912.jpg布莱顿大学的科学家已经证明能杀死细菌的病毒可以用来对抗因医用导管产生的常见感染。这个新观点可引起预防感染的新方法,有助于克服抗生素耐药性问题。这则消息在最近官方调查抗生素耐药性的结果表明,到2050年,死于抗生素耐药菌感染的人数可能超过癌症,而且需要户花费全球经济成本100万亿美元。Brian Jones博士领导的研究小组,一直致力于研究感染与尿导管的使用之间的关联,每年世界各地数以百万计的人们都要用尿道管。该研究团队集中研究一种特定种类的细菌称为变形杆菌,这种细菌室感染的常见原因,会导致导尿管广范围的结壳并堵塞导管。反过来,这导致肾脏感染和败血症等严重并发症的发生。Jones博士和他的团队评估潜在的一种病毒可以感染和杀死细菌,该病毒称为噬菌体可预防这类感染。Jones博士说:我们的工作提供了较好的初步证据表明,噬菌体可以治疗由变形杆菌引起的感染并防止导管堵塞。这可能提供了一种管理病人配备尿导管的新方法,提供给大量的病人便捷,同样有助于减少抗生素的使用和处理阻力Jones博士说需要更多的研究:我们在这个工作中仍然处于非常早期的阶段,在我们可以肯定产生有效的方法来控制这些感染之前有很长的路要走,但噬菌体已广泛使用在其他国家几十年了,抗生素耐药性促使人们选择这些有前途的抗生素替代物。布莱顿大学的科学家已经证明能杀死细菌的病毒可以用来对抗因医用导管产生的常见感染。这个新观点可引起预防感染的新方法,有助于克服抗生素耐药性问题。这则消息在最近官方调查抗生素耐药性的结果表明,到2050年,死于抗生素耐药菌感染的人数可能超过癌症,而且需要户花费全球经济成本100万亿美元。Brian Jones博士领导的研究小组,一直致力于研究感染与尿导管的使用之间的关联,每年世界各地数以百万计的人们都要用尿道管。该研究团队集中研究一种特定种类的细菌称为变形杆菌,这种细菌室感染的常见原因,会导致导尿管广范围的结壳并堵塞导管。反过来,这导致肾脏感染和败血症等严重并发症的发生。Jones博士和他的团队评估潜在的一种病毒可以感染和杀死细菌,该病毒称为噬菌体可预防这类感染。Jones博士说:我们的工作提供了较好的初步证据表明,噬菌体可以治疗由变形杆菌引起的感染并防止导管堵塞。这可能提供了一种管理病人配备尿导管的新方法,提供给大量的病人便捷,同样有助于减少抗生素的使用和处理阻力Jones博士说需要更多的研究:我们在这个工作中仍然处于非常早期的阶段,在我们可以肯定产生有效的方法来控制这些感染之前有很长的路要走,但噬菌体已广泛使用在其他国家几十年了,抗生素耐药性促使人们选择这些有前途的抗生素替代物。生物谷推荐阅读:Scientists at the University of Brighton have shown viruses that can kill bacteria may be used to combat common infections related to the use of medical devices such as catheters.This new insight could lead to new methods of preventing infections and could contribute to overcoming problems with antibiotic resistance. The news comes after the recent government review on the antibiotic resistance challenge suggested that deaths from antibiotic resistant infection could exceed deaths from cancer by 2050, and cost the global economy $100 trillion. A team led by Dr Brian Jones, Reader in Molecular and Medical Microbiology at the university’s College of Life, Health and Physical Sciences, has been studying infections associated with the use of urinary catheters which are used in their millions across the world every year. The team has focused on a particular species of bacteria called Proteus mirabilis, which is a common cause of these infections and leads to extensive encrustation and blockage of catheters. This, in turn, leads to the onset of serious complications such as kidney infection and septicaemia, one of the UK’s biggest killers. Dr Jones and his team have evaluated the potential for viruses that specifically infect and kill bacteria – called bacteriophage – to prevent these infections. Dr Jones, currently serving as Head of Research Development at Queen Victoria Hospital in East Grinstead, West Sussex, said: “Our work provides good initial evidence that bacteriophage can treat infections caused by Proteus mirabilis and prevent catheter blockage. “This could lead to new ways of managing patients fitted with urinary catheters, providing much benefit to a large number of patients, and also contribute to reducing antibiotic use and tackling resistance.”来源:生物谷
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