[转移贴]华人体内存在特殊基因 易感染H1N1流感病毒
ipsvirus发表于 2013-2-1据新加坡《联合早报》1月31日消息，中国和英国科研人员发现，华人容易感染H1N1流感病毒，这同一个基因（RS12252-C）有关。这也说明为何新流感病毒总是先在亚洲出现，这项新发现也有助于医生尽早找出高风险人群。
领导这项研究的英国牛津大学人员在《自然—通讯》期刊中发表了这一结果，他们指出因为具有这个基因，华人感染H1N1流感后，病情加重的风险比其他族群的人要高出六倍。
领导该项研究的董陶（音译）说：“找出一些人为何容易受感染的原因，可让我们更好应付流感来袭，预防更多人因病不治身亡。”
牛津科研人员指出，RS12252-C基因在华人人口中的普及率比西亚和欧洲的白种人高出100倍，在每3000个白种人中，只有1人有此种基因。此外，在2009年的华人重流感病患中，有69%的人体内有这个基因，而在那些病情轻的病患中，只有25%的人有这个基因。
世界卫生组织日前公布一项国际研究结果称，在2009年到2010年的流感季中，全世界每5人中就有1人感染甲型H1N1流感，但死亡率可能不到0.02%。
2009年6月，由于当时在74个国家和地区发现了甲型H1N1流感病毒，世界卫生组织宣布甲流全球大流行。直到2010年8月，世卫组织才宣布甲流全球大流行结束。
http://news.sciencenet.cn/htmlnews/2013/2/274529.shtm
ipsvirus发表于 2013-2-1
Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals
Yong-Hong Zhang, Yan Zhao, Ning Li, Yan-Chun Peng, Eleni Giannoulatou, Rong-Hua Jin, Hui-Ping Yan, Hao Wu, Jin-Hua Liu, Ning Liu, Da-Yan Wang, Yue-Long Shu, Ling-Pei Ho, Paul Kellam, Andrew McMichael & Tao Dong
The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C is much more common in Han Chinese. Here we report that the CC genotype is found in 69% of Chinese patients with severe pandemic influenza A H1N1/09 virus infection compared with 25% in those with mild infection. Specifically, the CC genotype was estimated to confer a sixfold greater risk for severe infection than the CT and TT genotypes. More importantly, because the risk genotype occurs with such a high frequency, its effect translates to a large population-attributable risk of 54.3% for severe infection in the Chinese population studied compared with 5.4% in Northern Europeans. Interferon-induced transmembrane protein-3 genetic variants could, therefore, have a strong effect of the epidemiology of influenza in China and in people of Chinese descent.
http://www.nature.com/ncomms/journal/v4/n1/full/ncomms2433.html
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