标题: CAR治疗技术用于恶性血液肿瘤：B细胞急性淋巴细胞白血病... [打印本页] 作者: icartab 时间: 2016-1-4 21:47 标题: CAR治疗技术用于恶性血液肿瘤：B细胞急性淋巴细胞白血病... CAR therapy for hematological cancers: can success seen in the treatment of B-cell acute lymphoblastic leukemia be applied to other hematological malignancies?
Chimeric antigen receptor (CAR) T-cell therapy has recently come into the spotlight due to impressive results in patients with B-cell acute lymphoblastic leukemia. By targeting CD19, a marker expressed most B-cell tumors, as well as normal B cells, CAR T-cell therapy has been investigated as a treatment strategy for B-cell leukemia and lymphoma. This review will discuss the successes of this therapy for the treatment of B-cell acute lymphoblastic leukemia and the challenges to this therapeutic strategy. We will also discuss application of CAR T-cell therapy to chronic lymphocytic leukemia and other B-cell malignancies including a follicular lymphoma, diffuse large B-cell lymphoma, as well as acute and plasma cell malignancies.
KEYWORDS:
B-cell malignancies; CAR; T cells; autologous T-cell infusion; chimeric antigen receptor; immunotherapy
CAR治疗技术用于恶性血液肿瘤：B细胞急性淋巴细胞白血病的成功治疗能否用于其他血液系统恶性肿瘤的治疗？