研究人员没有发现在实验鼠体内提高干扰素的产量会导致任何异常或副作用产生，他们知道，从人体内完全去除这两种基因是不可能的，但研究人员对利用其研究成果找到新的病毒治疗方法感到非常乐观。如果能够使用药物对付这两种基因，就可以使人们免遭病毒的侵袭。目前，这种药物虽然还不存在，但这正是今后的研究方向。作者: yafei 时间: 2016-2-2 16:11
Translational control of the innate immune response through IRF-7
Transcriptional activation of cytokines, such as type-I interferons (interferon (IFN)- and IFN-), constitutes the first line of antiviral defence. Here we show that translational control is critical for induction of type-I IFN production. In mouse embryonic fibroblasts lacking the translational repressors 4E-BP1 and 4E-BP2, the threshold for eliciting type-I IFN production is lowered. Consequently, replication of encephalomyocarditis virus, vesicular stomatitis virus, influenza virus and Sindbis virus is markedly suppressed. Furthermore, mice with both 4E- and 4E-BP2 genes (also known as Eif4ebp1 and Eif4ebp2, respectively) knocked out are resistant to vesicular stomatitis virus infection, and this correlates with an enhanced type-I IFN production in plasmacytoid dendritic cells and the expression of IFN-regulated genes in the lungs. The enhanced type-I IFN response in 4E-BP1 -/- 4E-BP2 -/- double knockout mouse embryonic fibroblasts is caused by upregulation of interferon regulatory factor 7 (Irf7) messenger RNA translation. These findings highlight the role of 4E-BPs as negative regulators of type-I IFN production, via translational repression of Irf7 mRNA.作者: yafei 时间: 2016-2-2 16:12
rojjer发表于 2008-2-21 21:45 ：