标题: Timothy M. Block，宾州，美国——HBV相关实验室及人物介绍系列 [打印本页] 作者: bigben446 时间: 2016-5-10 22:39 标题: Timothy M. Block，宾州，美国——HBV相关实验室及人物介绍系列
Timothy M. Block，宾州，美国——HBV相关实验室及人物介绍系列
Timothy M. Block，宾州，美国
Baruch S.Blumberg Institute, Doylestown, PA
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Liang, T. J. and T. M. Block, et al. (2015). "Present and future therapies of hepatitis B: From discovery to cure." Hepatology 62(6): 1893-908.
Yan, R. and X. Zhao, et al. (2015). "The Interferon-Inducible Protein Tetherin Inhibits Hepatitis B Virus Virion Secretion." J Virol 89(18): 9200-12.
Block, T. M. and S. Rawat, et al. (2015). "Chronic hepatitis B: A wave of new therapies on the horizon." Antiviral Res 121: 69-81.
Mao, R. and H. Nie, et al. (2013). "Inhibition of hepatitis B virus replication by the host zinc finger antiviral protein." PLoS Pathog 9(7): e1003494.
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Campagna, M. R. and F. Liu, et al. (2013). "Sulfamoylbenzamide derivatives inhibit the assembly of hepatitis B virus nucleocapsids." J Virol 87(12): 6931-42.
Block, T. M. and R. Gish, et al. (2013). "Chronic hepatitis B: what should be the goal for new therapies?" Antiviral Res 98(1): 27-34.
Chang, J. and T. M. Block, et al. (2012). "The innate immune response to hepatitis B virus infection: implications for pathogenesis and therapy." Antiviral Res 96(3): 405-13.
Cai, D. and C. Mills, et al. (2012). "Identification of disubstituted sulfonamide compounds as specific inhibitors of hepatitis B virus covalently closed circular DNA formation." Antimicrob Agents Chemother 56(8): 4277-88.
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Nie, H. and A. A. Evans, et al. (2011). "Quantification of complex precore mutations of hepatitis B virus by SimpleProbe real time PCR and dual melting analysis." J Clin Virol 51(4): 234-40.
Nie, H. and A. A. Evans, et al. (2011). "Ultrasensitive quantification of hepatitis B virus A1762T/G1764A mutant by a SimpleProbe PCR using a wild-type-selective PCR blocker and a primer-blocker-probe partial-overlap approach." J Clin Microbiol 49(7): 2440-8.
Mao, R. and J. Zhang, et al. (2011). "Indoleamine 2,3-dioxygenase mediates the antiviral effect of gamma interferon against hepatitis B virus in human hepatocyte-derived cells." J Virol 85(2): 1048-57.
Cohen, C. and S. D. Holmberg, et al. (2011). "Is chronic hepatitis B being undertreated in the United States?" J Viral Hepat 18(6): 377-83.
Norton, P. A. and S. Menne, et al. (2010). "Glucosidase inhibition enhances presentation of de-N-glycosylated hepatitis B virus epitopes by major histocompatibility complex class I in vitro and in woodchucks." Hepatology 52(4): 1242-50.
Xu, C. and H. Guo, et al. (2010). "Interferons accelerate decay of replication-competent nucleocapsids of hepatitis B virus." J Virol 84(18): 9332-40.
Lamontagne, J. and M. Pinkerton, et al. (2010). "Hepatitis B and hepatitis C virus replication upregulates serine protease inhibitor Kazal, resulting in cellular resistance to serine protease-dependent apoptosis." J Virol 84(2): 907-17.
Ren, X. D. and S. Y. Lin, et al. (2009). "Rapid and sensitive detection of hepatitis B virus 1762T/1764A double mutation from hepatocellular carcinomas using LNA-mediated PCR clamping and hybridization probes." J Virol Methods 158(1-2): 24-9.
Simsek, E. and G. Sinnathamby, et al. (2009). "Inhibition of cellular alpha-glucosidases results in increased presentation of hepatitis B virus glycoprotein-derived peptides by MHC class I." Virology 384(1): 12-5.
Guo, H. and D. Jiang, et al. (2009). "Activation of pattern recognition receptor-mediated innate immunity inhibits the replication of hepatitis B virus in human hepatocyte-derived cells." J Virol 83(2): 847-58.
Chang, J. and J. T. Guo, et al. (2008). "Liver-specific microRNA miR-122 enhances the replication of hepatitis C virus in nonhepatic cells." J Virol 82(16): 8215-23.
Balagopal, A. and F. H. Philp, et al. (2008). "Human immunodeficiency virus-related microbial translocation and progression of hepatitis C." Gastroenterology 135(1): 226-33.
Hann, H. W. and S. H. Han, et al. (2008). "Symptomatology and health attitudes of chronic hepatitis B patients in the USA." J Viral Hepat 15(1): 42-51.
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Mehta, A. S. and R. E. Long, et al. (2008). "Increased levels of galactose-deficient anti-Gal immunoglobulin G in the sera of hepatitis C virus-infected individuals with fibrosis and cirrhosis." J Virol 82(3): 1259-70.
Block, T. M. and H. Guo, et al. (2007). "Molecular virology of hepatitis B virus for clinicians." Clin Liver Dis 11(4): 685-706, vii.
Guo, H. and D. Jiang, et al. (2007). "Characterization of the intracellular deproteinized relaxed circular DNA of hepatitis B virus: an intermediate of covalently closed circular DNA formation." J Virol 81(22): 12472-84.
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Simsek, E. and X. Lu, et al. (2006). "alpha-Glucosidase inhibitors have a prolonged antiviral effect against hepatitis B virus through the sustained inhibition of the large and middle envelope glycoproteins." Antivir Chem Chemother 17(5): 259-67.
Zhou, T. and H. Guo, et al. (2006). "Hepatitis B virus e antigen production is dependent upon covalently closed circular (ccc) DNA in HepAD38 cell cultures and may serve as a cccDNA surrogate in antiviral screening assays." Antiviral Res 72(2): 116-24.
Block, T. M. and A. S. Mehta, et al. (2006). "Does rapid oligomerization of hepatitis B envelope proteins play a role in resistance to proteasome degradation and enhance chronicity?" DNA Cell Biol 25(3): 165-70.
Schwegler, E. E. and L. Cazares, et al. (2005). "SELDI-TOF MS profiling of serum for detection of the progression of chronic hepatitis C to hepatocellular carcinoma." Hepatology 41(3): 634-42.
Block, T. M. and W. T. London (2004). "Surrogate markers of efficacy for medical treatment of viral hepatitis." Biotechnol Healthc 1(5): 42-8.
Mehta, A. S. and B. Gu, et al. (2004). "alpha-Galactosylceramide and novel synthetic glycolipids directly induce the innate host defense pathway and have direct activity against hepatitis B and C viruses." Antimicrob Agents Chemother 48(6): 2085-90.
Comunale, M. A. and T. S. Mattu, et al. (2004). "Comparative proteomic analysis of de-N-glycosylated serum from hepatitis B carriers reveals polypeptides that correlate with disease status." Proteomics 4(3): 826-38.
Lu, X. and T. Tran, et al. (2003). "The alkylated imino sugar, n-(n-Nonyl)-deoxygalactonojirimycin, reduces the amount of hepatitis B virus nucleocapsid in tissue culture." J Virol 77(22): 11933-40.
Norton, P. A. and Q. Gong, et al. (2003). "Hepatitis B virus-mediated changes of apolipoprotein mRNA abundance in cultured hepatoma cells." J Virol 77(9): 5503-6.
Mehta, A. and B. Conyers, et al. (2002). "Structure-activity relationship of a new class of anti-hepatitis B virus agents." Antimicrob Agents Chemother 46(12): 4004-8.
Ouzounov, S. and A. Mehta, et al. (2002). "The combination of interferon alpha-2b and n-butyl deoxynojirimycin has a greater than additive antiviral effect upon production of infectious bovine viral diarrhea virus (BVDV) in vitro: implications for hepatitis C virus (HCV) therapy." Antiviral Res 55(3): 425-35.
Block, T. M. and R. Jordan (2001). "Iminosugars as possible broad spectrum anti hepatitis virus agents: the glucovirs and alkovirs." Antivir Chem Chemother 12(6): 317-25.
Lu, X. and Y. Lu, et al. (2001). "Hepatitis B virus MHBs antigen is selectively sensitive to glucosidase-mediated processing in the endoplasmic reticulum." DNA Cell Biol 20(10): 647-56.
Mehta, A. and S. Carrouee, et al. (2001). "Inhibition of hepatitis B virus DNA replication by imino sugars without the inhibition of the DNA polymerase: therapeutic implications." Hepatology 33(6): 1488-95.
Zitzmann, N. and A. S. Mehta, et al. (1999). "Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: implications for the development of broad spectrum anti-hepatitis virus agents." Proc Natl Acad Sci U S A 96(21): 11878-82.
Block, T. M. and X. Lu, et al. (1998). "Role of glycan processing in hepatitis B virus envelope protein trafficking." Adv Exp Med Biol 435: 207-16.
Mehta, A. and T. M. Block, et al. (1998). "The role of N-linked glycosylation in the secretion of hepatitis B virus." Adv Exp Med Biol 435: 195-205.
Lu, X. and A. Mehta, et al. (1997). "Aberrant trafficking of hepatitis B virus glycoproteins in cells in which N-glycan processing is inhibited." Proc Natl Acad Sci U S A 94(6): 2380-5.
Mehta, A. and X. Lu, et al. (1997). "Hepatitis B virus (HBV) envelope glycoproteins vary drastically in their sensitivity to glycan processing: evidence that alteration of a single N-linked glycosylation site can regulate HBV secretion." Proc Natl Acad Sci U S A 94(5): 1822-7.
Lu, X. and T. M. Block, et al. (1996). "Protease-induced infectivity of hepatitis B virus for a human hepatoblastoma cell line." J Virol 70(4): 2277-85.
Block, T. M. and X. Lu, et al. (1994). "Secretion of human hepatitis B virus is inhibited by the imino sugar N-butyldeoxynojirimycin." Proc Natl Acad Sci U S A 91(6): 2235-9.