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标题: 计算机辅助疫苗设计Computer-Aided Vaccine Design [打印本页]
作者: randomqd    时间: 2016-8-16 12:18
标题: 计算机辅助疫苗设计Computer-Aided Vaccine Design
本帖最后由 randomqd 于 2016-8-16 12:20 编辑
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$ }# Q1 o1 D" H$ P1st Edition0 `: B8 t' X; i! p8 v% \
Authors:  Joo Chuan Tong Shoba Ranganathan
0 |7 K8 G+ P2 f7 lElectronic ISBN 9781908818416  Print ISBN 9781907568411, K& A5 a( I& [! u
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Description  p  t( F- o8 K
Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.- d3 u9 E8 j( v  f" x7 ~
Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.
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, F5 [! C) N; H* s% Z# f" o/ UTable of Contents
2 e* Q* g2 R5 M6 DList of figures% A8 X8 a6 w8 o9 b/ d
List of abbreviations! q' ?( h5 _( B; O4 p
About the authors: X/ z' M  e# F: D3 U$ L
Preface
' }5 ^. y7 v9 Z+ F; lChapter 1: MHC and T cell responses& ~; a# n, w( m5 [5 }
Abstract:
5 P& F- y' N( T6 I9 d1.1 Genetic organization of the MHC
  a5 F: W* i6 D9 r: C8 m0 b1.2 MHC structure3 `- ?) \1 D, X' l& W1 D' C, N* g
1.3 MHC function# K- w! e) P8 Y
1.4 Peptide binding
& x) H4 N4 s4 }) J% Y# l6 aChapter 2: Immunoglobulins and B cell responses
6 `/ d) z& K7 s$ CAbstract:
$ g$ T& [2 k; m. L2.1 Types of immunoglobulins
) t: O- m6 e  B% D" N2.2 Immunoglobulin structure
' w5 W- a. h0 U2.3 Immunoglobulin function
) I4 S  p$ }2 N2.4 Antigen binding
4 l" T4 G& _- Y6 a4 T/ J$ J/ x/ \! XChapter 3: Scientific publications and databases
% q8 i/ Z& ]; n; n! l  oAbstract:5 X% r3 W6 x8 W8 b+ I
3.1 Bibliographical information
% r% `. w4 ?2 U  x8 I; F3.2 Searching the literature
  B$ K- T8 G. G1 ^5 e3.3 General databases containing information on genes and proteins
  f4 L4 d" k! m% O3.4 Immunological databases0 f+ r* @+ ~5 _; j, Z
3.5 Small molecule databases* x  T& w1 x, r8 t
Chapter 4: Database design
$ c7 C" ]0 ]. UAbstract:1 V, i. e: v* K" B
4.1 Fundamentals of database design; m# F. ^6 y7 x- A; p
4.2 ER diagram
; N3 n6 z" G% H! z" |4.3 Normalization and normal forms: l+ {4 I& V8 ?" v, W* W" z; b; G
Chapter 5: Computational T cell vaccine design7 t, U8 `2 I6 N4 U9 L
Abstract:; O( p  x9 v/ y3 I6 a6 H! c6 O0 p
5.1 Sequence-based methods
* {% ~6 b  |1 d5.2 Structure-based methods
" O$ X; W. v9 J2 T3 O5.3 Broad-based T cell vaccine design
. e- C; Z0 C3 i9 @/ QChapter 6: Computational B cell vaccine design7 w; N, t6 |; [
Abstract:
) F& Z# O. N, ~% E7 a7 C1 x8 v6 Y6.1 Sequence-based methods
0 o5 O2 ]0 i% v, C# E& q/ ?/ P6.2 Structure-based methods( C0 W' {: c' E) |* N  w  x
Chapter 7: Infectious disease informatics
# E$ R/ |  y, [# d+ j9 J6 eAbstract:" r% X$ n/ B0 l$ Z$ m
7.1 Infectious diseases in history
! C7 }$ \5 O/ w/ \5 q% x+ u$ I( z" F8 h7.2 Microbial sequence analysis
, g/ B4 j' ^) n. y7.3 Detecting natural selection in molecular evolution
; s( ^0 ^8 \" WChapter 8: Vaccine safety and quality assessments7 Q5 e: P2 z; H2 x$ f$ P
Abstract:
) }0 R, U9 D' S+ d) ]% ], s/ p8.1 Assessment of ADME/Tox deficiencies
5 A2 R3 {3 x' \/ w: P5 O+ e8.2 Assessment of allergenicity" J* ]$ i2 b4 g
Chapter 9: Vaccine adjuvant informatics$ W* x2 U1 `& w: z( r& t& ]
Abstract:4 a- ]# d3 L! V
9.1 Virtual combinatorial library
5 N, X" f8 H  v& C; i9.2 Chemical file formats
# |9 Z7 O0 p" O9.3 Considerations for virtual library design& D* A9 q/ s4 G, Y" S: h0 e
Index  [5 N9 }! g% S  O4 N& p- n
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作者: dianhh012786    时间: 2016-8-22 08:40
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作者: xiaoniao1216    时间: 2018-1-22 13:06
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作者: LMC    时间: 2024-3-1 20:08
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