寨卡病毒与多种类型的眼睛损伤---包括新生儿中的眼睛炎症和失明---相关联。在小鼠体内开展的一项研究也提示着寨卡病毒感染导致视通路神经元中的细胞死亡。相关研究结果于2016年9月6日在线发表在Cell Reports期刊上,论文标题为“Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears”。
[size=0.8465em]JAMA Ophthalmol. 2016 Sep 15. doi: 10.1001/jamaophthalmol.2016.3417. [Epub ahead of print] Presence of Zika Virus in Conjunctival Fluid.
Zika virus (ZIKV) is a mosquito-borne flavivirus isolated from the Zika forest of Uganda in 1947.[size=0.846em]1The clinical symptoms of ZIKV infection are mostly a mild and self-limited rash, arthralgia, and conjunctivitis in humans. More than 80% of ZIKV infections are asymptomatic. The ZIKV outbreaks in Brazil and French Polynesia indicate that the virus is linked to microcephaly and Guillain-Barré syndrome.[size=0.846em]2[size=0.846em],3 Meanwhile, severe eye damage in infants with microcephaly was associated with ZIKV infection.[size=0.846em]4 However, it is still unclear whether the eye lesions are the result of microcephaly or directly ZIKV infection.[size=0.846em]5 Therefore, we wondered whether ZIKV could be detected in conjunctival fluid. In this report, we describe the detection of ZIKV from conjunctival swab samples of laboratory-confirmed ZIKV cases.