舒红兵研究组近年来对抗病毒天然免疫中关键的接头蛋白的蛋白翻译后修饰包括苏素化、泛素化和磷酸化等进行了广泛深入的研究，这些研究揭示了蛋白翻译后修饰在抗病毒天然免疫反应动态过程中的精细调节作用。为病毒感染引发的相关疾病以及自身免疫疾病等的防治提供了理论依据和潜在的分子靶标。
最新的这项研究工作主要由舒红兵研究组的博士后胡明明、杨清以及博士生廖晨阳等完成，舒红兵是责任作者。该研究在国家重大科学研究计划、国家自然科学基金创新研究群体和重点项目的资助下完成。
Title：Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5.
Abstract
Sensing of viral RNA by the cytosolic receptors RIG-I and melanoma differentiation-associated gene 5 (MDA5) leads to innate antiviral response. How RIG-I and MDA5 are dynamically regulated in innate antiviral response is not well understood. Here, we show that TRIM38 positively regulates MDA5- and RIG-I-mediated induction of downstream genes and acts as a SUMO E3 ligase for their dynamic sumoylation at K43/K865 and K96/K888, respectively, before and after viral infection. The sumoylation of MDA5 and RIG-Isuppresses their K48-linked polyubiquitination and degradation in uninfected or early-infected cells. Sumoylation of the caspase recruitment domains of MDA5 and RIG-I is also required for their dephosphorylation by PP1 and activation upon viral infection. At the late phase of viral infection, both MDA5 and RIG-I are desumoylated by SENP2, resulting in their K48-linked polyubiquitination and degradation. These findings suggest that dynamic sumoylation and desumoylation of MDA5 and RIG-I modulate efficient innateimmunity to RNA virus and its timely termination.作者: 矢豆矢豆 时间: 2017-3-4 20:11
棒棒作者: Ascovirus 时间: 2017-3-4 22:17
棒棒哒作者: cao1976 时间: 2017-3-4 23:01
舒院士年轻有为啊
