【书名版次】: Adeno-Associated Virus: Methods and Protocols (Methods in Molecular Biology)
【作 者】:Richard O. Snyder (Editor), Philippe Moullier (Editor)2 N L$ G! D2 ~6 A, e2 N
【出 版 社】: Humana Press; 2011 edition6 l* ?+ Z9 z2 l4 @2 h
【出版日期】: (November 30, 2011)
【简 介】: Today, progress in rAAV-mediated gene transfer is so robust that long-term, efficient, and regulatable transgene expression is reproducibly achieved in large animal models. The complexity of gene transfer agents in the context of their clinical use requires investigators from a wide variety of backgrounds to have an understanding — or at least an appreciation of — the regulatory environment and constraints that affect vector design, manufacturing, pre-clinical testing, and clinical use, with an emphasis on patient protection. In Adeno-Associated Virus: Methods and Protocols, experts from the United States and Europe have contributed current knowledge of this multi-dimensional field relating to the biology of AAV, rAAV vector design, vector manufacturing and product testing, performance of rAAV vectors in major organs, rAAV-related immunological issues, design of animal and clinical studies, and clinical experience. Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Adeno-Associated Virus: Methods and Protocols provides a complete and comprehensive understanding of this multi-disciplinary and rapidly progressing field. |( K7 v. o" ]" m6 Q( Y- _
【目 录】:
Hardcover: 475 pages
Language: English
ISBN-10: 16177936988 V V0 W1 c! h1 z: ]8 J* T
ISBN-13: 978-1617793691
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