【书名版次】：Hepatitis Delta Virus（First edition）
【作 者】：J. L. Casey
【出 版 社】: Springer
【简 介】：
Since its discovery nearly 30 years ago, hepatitis delta virus (HDV) has continued
to surprise and fascinate. Initially thought to be an antigenic variant
of hepatitis B virus (HBV), HDV was soon found to be a defective virus that
depends on an underlying or simultaneous hepatitis B infection. The clinical
significance of HDV infection is more severe acute and chronic liver disease
than that caused by the HBV infection alone. The cloning and sequencing of
the genome led to the realization thatHDV is a unique RNA virus whose closest
known relatives are plant viroids, but even that relationship is remote. In
the current classification scheme of the International Congress on the Taxonomy
ofViruses,HDVremains the solemember of a floating genus, Deltavirus.
The genome and its replication cycle bear no discernable resemblance to its
helper virus, HBV, on which HDV depends for its envelope.
The more we continue to learn about hepatitis delta virus the more fascinating
it becomes. It is my hope that this book will stimulate additional
interest in hepatitis delta virus among scientists, academic researchers and
advanced students. I would like to thank the authors for their contributions,
and the staff at Springer and members of my laboratory for their assistance
in preparing this volume.
【出版日期】：2006
【目 录】：
List of Contents
Structure andReplicationofHepatitisDeltaVirusRNA . . . . . . . . . . . . . . . . . . 1
J. M. Taylor
HDVRNAReplication:AncientRelic or Primer? . . . . . . . . . . . . . . . . . . . . . . . 25
T. B.Macnaughton andM. M. C. Lai
HDVRibozymes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47
M. D. Been
RNAEditing inHepatitisDeltaVirus . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67
J. L. Casey
Post-translationalModification ofDeltaAntigen ofHepatitisDVirus . . . . . . . . 91
W.-H. Huang, C.-W. Chen, H.-L.Wu, and P.-J. Chen
TheRole of theHBVEnvelopeProteins in theHDVReplicationCycle . . . . . . . . 113
C. Sureau
Prenylation of HDAg and Antiviral Drug Development . . . . . . . . . . . . . . . . . . . 133
J. S. Glenn
Hepatitis Delta Virus Genetic Variability:
FromGenotypes I, II, III to EightMajorClades? . . . . . . . . . . . . . . . . . . . . . . . 151
P. Dény
Functional and Clinical Significance
ofHepatitisDVirusGenotype II Infection . . . . . . . . . . . . . . . . . . . . . . . . . . . 173
J.-C. Wu
Immunology ofHDVInfection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 187
M. Fiedler and M. Roggendorf
TheWoodchuckModel ofHDVInfection . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211
J. L. Casey and J. L. Gerin
Subject Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 226