标题: 【转移帖】IL-21 Is Required to Control Chronic Viral Infection [打印本页] 作者: hantavirus 时间: 2015-8-22 13:59 标题: 【转移帖】IL-21 Is Required to Control Chronic Viral Infection 原帖由yaoming发表于 2009-9-28 01:26 ：
[最新进展] IL-21 Is Required to Control Chronic Viral Infection
本帖最后由 yaoming 于 2009-9-28 01:31 编辑
CD4+ and CD8+ T cell functions are rapidly aborted during chronic infection, preventing viral clearance. CD4+ T cell help is required throughout chronic infection so as to sustain CD8+ T cell responses; however, the necessary factor(s) provided by CD4+ T cells are currently unknown. Using a mouse model of chronic viral infection, we demonstrated that interleukin-21 (IL-21) is an essential component of CD4+ T cell help. In the absence of IL-21 signaling, despite elevated CD4+ T cell responses, CD8+ T cell responses are severely impaired. CD8+ T cells directly require IL-21 to avoid deletion, maintain immunity, and resolve persistent infection. Thus, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection.
science 前后共发表了三篇类似的文章:
1. IL-21 Is Required to Control Chronic Viral Infection Heidi Elsaesser, Karsten Sauer, and David G. Brooks
Science 19 June 2009 324: 1569-1572; published online 7 May 2009 [DOI: 10.1126/science.1174182] (in Reports)
2. A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection John S. Yi, Ming Du, and Allan J. Zajac Science 19 June 2009 324: 1572-1576; published online 14 May 2009 [DOI: 10.1126/science.1175194] (in Reports)
3. IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection
Anja Fröhlich, Jan Kisielow, Iwana Schmitz, Stefan Freigang, Abdijapar T. Shamshiev, Jacqueline Weber, Benjamin J. Marsland, Annette Oxenius, and Manfred Kopf Science 19 June 2009 324: 1576-1580; published online 28 May 2009 [DOI: 10.1126/science.1172815] (in Reports)