这是全基因组关联分析（Genome-Wide Association Studie， GWAS）技术取得最为重要的一项成果，因为它能马上临床转化，让患者受益。该研究成果发表在Nature杂志上（Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance），文章的第一作者是来自杜克大学的葛东亮博士，99年毕业于上海医科大学，现任杜克大学基因组科学与政策研究院人类基因组变异研究中心助理教授（具体简介见文章后）。
· 上述方法在全基因组关联分析（Genome-Wide Association Studie， GWAS）和全基因组测序分析中(Whole-Genome Sequencing studies, next-generation sequencing studies)的应用。
学术活动
* 评委- 美国人类遗传学协会58届年会，第16主题：定位、连锁、连锁不平衡。The 58th Annual American Society of Human Genetics meeting, Philadelphia, PA, Nov 2008, topic #16: Mapping, linkage and linkage disequilibrium, 2008
* 评委- 奥地利国家基因组研究计划，生物信息学整合网络III. The Federal Austrian Ministry of Science and Research, Austrian National Genome Research Programme. Bioinformatics Integration Network III, 2008
* 评委- BMC genomics （杂志）
* 评委- American Heart Journal（杂志）
* 评委- Genome Research（杂志）
* 评委- Hypertension（杂志）
* 受邀教员- “Whole Genome Association Studies: Understanding the Genetic Basis of Susceptibility to Infectious Diseases.” 美国热带医学协会第57 届年会。The 57th American Society of Tropical Medicine and Hygiene (ASTMH) pre-annual meeting course, Dec 2008, New Orleans, LA. (http://www.astmh.org/)
* 受邀教员– “HIV Host Genomics Hands-on-Computer Workshop” 第15届反转录病毒与机会感染大会。Feb 2008, The 15th Conference on Retroviruses and Opportunistic Infections (CROI 2008), Boston, MA. (http://www.retroconference.org/2008/)
* 首席教员- “Demonstration of Methods for Performing Whole-Genome Association Studies,” March 2008, 杜克大学, 全基因组关联分析研讨会。Duke University, Durham NC. (http://www.genome.duke.edu/centers/pg2/workshops/)
* 受邀报告人- WGAViewer: A Software for Genomic Annotation of Whole Genome Association Studies: Usage in Discovering Major Determinants for HIV-1 Host Control. 葛兰素史克威尔康制药GlaxoSmithKline. Research Triangle, NC; Jan 2008 and Feb 2008.
* 受邀报告人- A computer software pipeline for genome-wide association studies. 图兰大学。Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; Oct 2007.
* 受邀报告人: A Pipeline for Genome-Wide Association Analyses and Annotation: Engines for Discovering Major Determinants for HIV-1 Host Control. 华盛顿大学。Washington University in St. Louis, MO; Sep 2008.
* 会员- American Public Health Association 美国公共卫生联盟
* 会员- American Heart Association美国心脏病联盟
* 会员- American Society of Human Genetics美国人类遗传学协会
* 2008 North Carolina Educational Event Award, North Carolina Biotechnology Center. 北卡罗莱纳州教育活动奖，颁奖人：北卡罗莱纳州生物技术中心
* 2008. Educational Program Award, 先灵葆雅制药Schering Plough Research Institute, Kenilworth, New Jersey. (For supporting workshop “Demonstration of Methods for Performing Whole-Genome Association Studies”)
Education & Research Experience
杜克大学基因组科学与政策研究院，人类基因组变异研究中心， Durham, NC, USA
助理教授，2009 年1月至今
杜克大学基因组科学与政策研究院，人类基因组变异研究中心, Durham, NC, USA
博士后，2006 年9月至2008年12月。指导教授：David B. Goldstein, PhD.
1. Ge D*, Fellay J*, Thompson AJ*, Simon JS*, Shianna KV, Urban TJ, Heinzen EL, Qiu P, Bertelsen AH, Muir AJ, Sulkowski M, McHutchison JG, Goldstein DB. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature （自然）2009.
2. Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, Rujescu D, Werge T, Pietilainen OP, Mors O, Mortensen PB, Sigurdsson E, Gustafsson O, Nyegaard M, Tuulio-Henriksson A, Ingason A, Hansen T, Suvisaari J, Lonnqvist J, Paunio T, Borglum AD, Hartmann A, Fink-Jensen A, Nordentoft M, Hougaard D, Norgaard-Pedersen B, Bottcher Y, Olesen J, Breuer R, Moller HJ, Giegling I, Rasmussen HB, Timm S, Mattheisen M, Bitter I, Rethelyi JM, Magnusdottir BB, Sigmundsson T, Olason P, Masson G, Gulcher JR, Haraldsson M, Fossdal R, Thorgeirsson TE, Thorsteinsdottir U, Ruggeri M, Tosato S, Franke B, Strengman E, Kiemeney LA, Group, Melle I, Djurovic S, Abramova L, Kaleda V, Sanjuan J, de Frutos R, Bramon E, Vassos E, Fraser G, Ettinger U, Picchioni M, Walker N, Toulopoulou T, Need AC, Ge D, Lim Yoon J, Shianna KV, Freimer NB, Cantor RM, Murray R, Kong A, Golimbet V, Carracedo A, Arango C, Costas J, Jonsson EG, Terenius L, Agartz I, Petursson H, Nothen MM, Rietschel M, Matthews PM, Muglia P, Peltonen L, St Clair D, Goldstein DB, Stefansson K, Collier DA, Kahn RS, Linszen DH, van Os J, Wiersma D, Bruggeman R, Cahn W, de Haan L, Krabbendam L, Myin-Germeys I. Common variants conferring risk of schizophrenia. Nature （自然）2009.
3. Stefansson H, Rujescu D, Cichon S, Pietilainen OP, Ingason A, Steinberg S, Fossdal R, Sigurdsson E, Sigmundsson T, Buizer-Voskamp JE, Hansen T, Jakobsen KD, Muglia P, Francks C, Matthews PM, Gylfason A, Halldorsson BV, Gudbjartsson D, Thorgeirsson TE, Sigurdsson A, Jonasdottir A, Jonasdottir A, Bjornsson A, Mattiasdottir S, Blondal T, Haraldsson M, Magnusdottir BB, Giegling I, Moller HJ, Hartmann A, Shianna KV, Ge D , Need AC, Crombie C, Fraser G, Walker N, Lonnqvist J, Suvisaari J, Tuulio-Henriksson A, Paunio T, Toulopoulou T, Bramon E, Di Forti M, Murray R, Ruggeri M, Vassos E, Tosato S, Walshe M, Li T, Vasilescu C, Muhleisen TW, Wang AG, Ullum H, Djurovic S, Melle I, Olesen J, Kiemeney LA, Franke B, Kahn RS, Linszen D, van Os J, Wiersma D, Bruggeman R, Cahn W, Germeys I, de Haan L, Krabbendam L, Sabatti C, Freimer NB, Gulcher JR, Thorsteinsdottir U, Kong A, Andreassen OA, Ophoff RA, Georgi A, Rietschel M, Werge T, Petursson H, Goldstein DB, Nothen MM, Peltonen L, Collier DA, St Clair D, Stefansson K. Large recurrent microdeletions associated with schizophrenia. Nature . （自然）2008;455(7210):232-6.
4. Fellay J, Shianna KV *, Ge D *, Colombo S *, Ledergerber B *, Weale M *, Zhang K, Gumbs C, Castagna A, Cossarizza A, Cozzi-Lepri A, De Luca A, Easterbrook P, Francioli P, Mallal S, Martinez-Picado J, Miro JM, Obel N, Smith JP, Wyniger J, Descombes P, Antonarakis SE, Letvin NL, McMichael AJ, Haynes BF, Telenti A, Goldstein DB. A whole-genome association study of major determinants for host control of HIV-1. Science .（科学）2007;317(5840):944-7. (* Equal authors)
5. Walley NM, Julg B, Dickson SP, Fellay J, Ge D, Walker BD, Carrington M, Cohen MS, de Bakker PI, Goldstein DB, Shianna KV, Haynes BF, Letvin NL, McMichael AJ, Michael NL, Weintrob AC. The Duffy antigen receptor for chemokines null promoter variant does not influence HIV-1 acquisition or disease progression. Cell Host Microbe （细胞，宿主及微生物）2009; 5 (5) : 408-10.
6. Pillai SG, Ge D *, Zhu G*, Kong X*, Shianna KV, Need AC, S. F, Hersh CP, Bakkgators, Rennard SI, Lomas D, Silverman EK, Goldstein DB. A Genome-wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of two Major Susceptibility Loci. PLoS Genet . 2009; 5(3): e1000421. doi:10.1371/journal.pgen.1000421 (* Equal authors)
7. Need AC *, Ge D * , Maia J, Shianna KV, Feng S, Strittmatter WJ, McEvoy JP, Keefe RSE, St Jean PL, Giegling I, Hartmann AM, M?ller H, Ruppert A, Fraser G, Crombie C, Francks C, St.Clair D, Roses AD, Muglia P, Rujescu D, Goldstein DB. A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia. PLoS Genet. 2009; 5(2):e1000373.(* Equal authors)
8. Heinzen E *, Ge D *, Cronin KD, Maia J, Shianna KV, Gabriel W, Welsh-Bohmer KA, Hulette CM, Denny T, Goldstein DB. Tissue specific genetic control of gene expression and alternative splicing: Implications for the study of human complex traits. PLoS Biol . 2008; 6(12): e1000001. (* Equal authors)
9. Ge D , Zhang K, Need AC, Martin O, Fellay J, Urban TJ, Telenti A, Goldstein DB. WGAViewer: Software for genomic annotation of whole genome association studies. Genome Res . 2008;18(4):640-3.
10. Price AL, Weale ME, Patterson N, Myers SR, Need AC, Shianna KV, Ge D , Rotter JI, Torres E, Taylor KD, Goldstein DB, Reich D. Long-range LD can confound genome scans in admixed populations. Am J Hum Genet 2008 . 83(1):132-5; author reply 135-9.
11. Cavalleri GL, Weale ME, Shianna KV, Singh R, Lynch JM, Grinton B, Szoeke C, Murphy K, Kinirons P, O'Rourke D, Ge D , Depondt C, Claeys KG, Pandolfo M, Gumbs C, Walley N, McNamara J, Mulley JC, Linney KN, Sheffield LJ, Radtke RA, Tate SK, Chissoe SL, Gibson RA, Hosford D, Stanton A, Graves TD, Hanna MG, Eriksson K, Kantanen AM, Kalviainen R, O'Brien TJ, Sander JW, Duncan JS, Scheffer IE, Berkovic SF, Wood NW, Doherty CP, Delanty N, Sisodiya SM, Goldstein DB. Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study. Lancet Neurol. 2007;6(11):970-80.
12. Cronin KD, Ge D, Manninger P, Linnertz C, Rossoshek A, Orrison BM, Bernard DJ, El-Agnaf OM, Schlossmacher MG, Nussbaum RL, Chiba-Falek O. Expansion of the Parkinson Disease-Associated SNCA-Rep1 Allele Up-Regulates Human {alpha}-Synuclein in Transgenic Mouse Brain. Hum Mol Genet 2009.
13. Need AC, Keefe RS, Ge D, Grossman I, Dickson S, McEvoy JP, Goldstein DB. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. Eur J Hum Genet 2009; 17 (7) : 946-57 .
14. Ge D , Su S, Zhu H, Dong Y, Wang X, Harshfield GA, Treiber FA, Snieder H. Stress-Induced Sodium Excretion. A New Intermediate Phenotype to Study the Early Genetic Etiology of Hypertension? Hypertension 2009;53:262-269
15. Ge D , Gooljar SB, Kyriakou T, Collins LJ, Swaminathan R, Snieder H, Spector TD, O'Dell SD. Association of Common JAK2 Variants With Body Fat, Insulin Sensitivity and Lipid Profile. Obesity (Silver Spring) 2008;16(2) : 492-6.
16. Ge D, Zhu H, Huang Y, Treiber FA, Harshfield GA, Snieder H, Dong Y. Multilocus analyses of Renin-Angiotensin-aldosterone system gene variants on blood pressure at rest and during behavioral stress in young normotensive subjects. Hypertension . 2007 ;49(1):107-12.
17. Ge D, Young TW, Wang X, Kapuku GK, Treiber FA, Snieder H. Heritability of arterial stiffness in black and white American youth and young adults. Am J Hypertens 2007;20(10) : 1065-72.
18. Kapuku GK, Ge D, Vemulapalli S, Harshfield GA, Treiber FA, Snieder H. Change of genetic determinants of left ventricular structure in adolescence: longitudinal evidence from the Georgia cardiovascular twin study. Am J Hypertens 2008;21(7):799-805.
19. Oberg S, Ge D, Cnattingius S, Svensson A, Treiber FA, Snieder H, Iliadou A. Ethnic differences in the association of birth weight and blood pressure the georgia cardiovascular twin study. Am J Hypertens 2007;20(12):1235-41.
20. Zhu H, Yan W, Ge D , Treiber FA, Harshfield GA, Kapuku G, Snieder H, Dong Y. Relationships of cardiovascular phenotypes with healthy weight, at risk of overweight, and overweight in US youths. Pediatrics 2008;121(1) : 115-22.
21. Wang L, Li B, Lu X, Zhao Q, Li Y, Ge D, Li H, Zhang P, Chen S, Chen R, Qiang B, Gu D. A functional intronic variant in tyrosine hydroxylase (TH) gene confers risk of essential hypertension in northern Chinese Han population. Clin Sci (Lond) 2008.
22. Dalageorgou C, Ge D , Jamshidi Y, Nolte IM, Riese H, Savelieva I, Carter ND, Spector TD, Snieder H. Heritability of QT Interval: How Much Is Explained by Genes for Resting Heart Rate? J Cardiovasc Electrophysiol 2007.
23. Morell RJ, Brewer CC, Ge D , Snieder H, Zalewski CK, King KA, Drayna D, Friedman TB. A twin study of auditory processing indicates that dichotic listening ability is a strongly heritable trait. Hum Genet 2007;122(1):103-11.
24. Zhu H, Yan W, Ge D, Treiber FA, Harshfield GA, Kapuku G, Snieder H, Dong Y. Cardiovascular characteristics in American youth with prehypertension. Am J Hypertens 2007;20(10):1051-7.
25. Jamshidi Y, Snieder H, Ge D , Spector TD, O'Dell SD. The SH2B gene is associated with serum leptin and body fat in normal female twins. Obesity (Silver Spring) . 2007;15(1):5-9.
26. Healey PR, Mitchell P, Gilbert CE, Lee AJ, Ge D , Snieder H, Spector TD, Hammond CJ. The inheritance of peripapillary atrophy. Invest Ophthalmol Vis Sci 2007;48(6):2529-34.
27. Weili Y, He B, Yao H, Dai J, Cui J, Ge D , Zheng Y, Li L, Guo Y, Xiao K, Fu X, Ma D. Waist-to-height ratio is an accurate and easier index for evaluating obesity in children and adolescents. Obesity (Silver Spring) 2007;15(3):748-52.
28. Jamshidi Y, Gooljar SB, Snieder H, Wang X, Ge D , Swaminathan R, Spector TD, O'Dell SD. SHP-2 and PI3-kinase genes PTPN11 and PIK3R1 may influence serum apoB and LDL cholesterol levels in normal women. Atherosclerosis 2007; 194 (2) : e26-33
29. Ge D, Dong Y, Wang X, Treiber FA, Snieder H. The Georgia Cardiovascular Twin Study: influence of genetic predisposition and chronic stress on risk for cardiovascular disease and type 2 diabetes.
30. Twin Res Hum Genet . 2006;9(6):965-70.
31. Spencer-Jones NJ*, Ge D *, Snieder H, Perks U, Swaminathan R, Spector TD, Carter ND, O'Dell SD. AMP-kinase alpha2 subunit gene PRKAA2 variants are associated with total cholesterol, low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol in normal women. Journal of Medical Genetics. 2006 ;43(12):936-42. (* Joint authors.)
32. Gu D, Ge D, Snieder H, He J, Chen S, Huang J, Li B, Chen R, Qiang B. Association of alpha-1A adrenergic receptor gene variants on chromosome 8p21 with human stage-2 hypertension. Journal of Hypertension , 2006;24(6):1057-1064.
33. Kupper N, Ge D, Treiber FA, Snieder H . Tracking of blood pressure and underlying hemodynamics in European and African American adolescents. Stable heritabilities and expression of new genes. Hypertension , 2006 47(5):948-54 .
34. Gu D, Su S, Ge D, Chen S, Huang J, Li B, Chen R, Qiang B. An Association Study with 33 SNPs in 11 Candidate Genes for Hypertension in Chinese. Hypertension , 2006;47(6):1147-54.
35. Herold SE, Young TW, Ge D, Snieder H, Lovrekovic GZ. Sleep Disordered Breathing in Pediatric Patients with Tetralogy of Fallot. Pediatric Cardiology , 2006;27(2):243-9.
36. de Lange M, Andrew T, Snieder H, Ge D, Futers TS, Standeven K, Spector TD, Grant PJ and Ariens RAS. Joint linkage and association of 6 single nucleotide polymorphisms in the factor XIII-A subunit gene point to V34L as the main functional locus. Arteriosclerosis, Thrombosis, and Vascular Biology . 2006 Aug;26(8):1914-9.
37. Yang W, Huang J, Yao C, Su S, Liu D, Ge D , Gu D. Linkage and linkage disequilibrium analysis of the lipoprotein lipase gene with lipid profiles in Chinese hypertensive families. Clinical Science (Lond). 2005;108(2):137-142.
38. Ge D, Huang J, Yang W, Zhao J, Shen Y, Qiang B, Gu D. Linkage analysis of chromosome 1 with essential hypertension and blood pressure quantitative traits in Chinese families. Annals of Human Genetics . 2005;69(Pt 1):45-54.
39. Ge D , Huang J, He J, Li B, Duan X, Chen R, Gu D. beta2-Adrenergic receptor gene variations associated with stage-2 hypertension in northern Han Chinese. Annals of Human Genetics . 2005;69(Pt 1):36-44.
40. Li B, Ge D , Wang Y, Zhao W, Zhou X, Gu D, Chen R. G Protein beta3 Subunit Gene Variants and Essential Hypertension in the Northern Chinese Han Population. Annals of Human Genetics . 2005;69(Pt 4):468-473.
41. Chen S, Yan W, Huang J, Ge D, Yao Z, Gu D. Association analysis of the variant in the regulatory subunit of phosphoinositide 3-kinase (p85alpha) with Type 2 diabetes mellitus and hypertension in the Chinese Han population. Diabetic Medicine . 2005;22(6):737-743.
42. Yan W, Yang X, Zheng Y, Ge D , Zhang Y, Shan Z , Simu H , Sukerobai M , Wang R . The Metabolic Syndrome in Uygur and Kazak Population. Diabetes Care . 28(10):2554-5, 2005.
43. Zhou X, Huang J, Chen J, Zhao J, Ge D , Yang W, Gu D. Genetic association analysis of myocardial infarction with thrombospondin-1 N700S variant in a Chinese population. Thrombosis Research . 2004;113(3-4):181-186.
44. Gu D, Ge D, He J, Li B, Chen J, Liu D, Chen J, Chen R. Haplotypic analyses of the aldosterone synthase gene CYP11B2 associated with stage-2 hypertension in northern Han Chinese. Clinical Genetics . 2004;66(5):409-416.
45. Li B, Ge D, Wang Y, Zhao W, Zhou X, Gu D, Chen R. Lipoprotein lipase gene polymorphisms and blood pressure levels in the Northern Chinese Han population. Hypertension Research . 2004;27(6):373-378.
46. Gu F, Ge D, Huang J, Chen J, Yang W, Gu D. Genetic susceptibility loci for essential hypertension and blood pressure on chromosome 17 in 147 Chinese pedigrees. Journal of Hypertension . 2004;22(8):1511-1518.
47. Gu D, Ge D. The New Genetics in Hypertension: Asia Pacific Perspective. Paper presented at: 3rd Asian-Pacific Congress of Hypertension; April 3-7, 2004; Singapore.
48. Yang W, Huang J, Ge D , Yao C, Duan X, Shen Y, Qiang B, Gu D. Lipoprotein lipase gene is in linkage with blood pressure phenotypes in Chinese pedigrees. Human Genetics. 2004;115(1):8-12.
49. Ge D, Yang W, Huang J, Yao C, Xu X, Gan W, Zhao J, Liu D, Wang X, Duan X, Hui R, Shen Y, Yao Z, Qiang B, Gu D. Linkage analysis of 2q14-q23 and 5q32 with blood pressure quantitative traits in Chinese sib pairs. Journal of Hypertension . 2003;21(2):305-310.
50. Yang W, Huang J, Ge D, Yao C, Duan X, Gan W, Huang G, Zhao J, Hui R, Shen Y, Qiang B, Gu D. Variation near the region of the lipoprotein lipase gene and hypertension or blood pressure levels in Chinese. Hypertension Research. 2003;26(6):459-464.
51. Yang WJ, Huang JF, Yao CL, Fan ZJ, Ge D , Gan WQ, Huang GY, Hui RT, Shen Y, Qiang BQ, Gu DF. Evidence for linkage and association of the markers near the LPL gene with hypertension in Chinese families. Journal of Medical Genetics. 2003;40(5):e57.