中国病毒学论坛|我们一直在坚持！

标题: Scientific reports:发现中国农村人乳头瘤病毒传播特征 [打印本页]

作者: ipsvirus 时间: 2015-8-28 14:20
标题: Scientific reports:发现中国农村人乳头瘤病毒传播特征

发表在《科学报告》上的一篇论文显示，中国农村地区男性向女性传播可引发宫颈癌的人乳头瘤病毒（HPV）的风险比女性向男性传播的风险高4倍。

据介绍，HPV感染可以导致女性患宫颈癌，也存在引发口咽部癌症和肛门生殖器癌症的风险。以往研究显示，男性感染HPV会增加其伴侣宫颈癌的风险。但一直以来，中国普通人群中的HPV传播特性研究却很少。

北京大学肿瘤医院的柯杨、蔡红及其研究团队从2009~2013年间追踪了874对年龄从25岁到65岁的中国农村地区夫妇生殖器HPV感染情况，其间，研究人员对跟踪对象每半年做一次检查，约进行了7次检查。他们发现，年轻夫妇传染HPV的风险更高。分析还显示，男性向女性传染致癌性HPV的风险为每月每千人中有12.13人会被传染，比女性传染给男性致癌性HPV的风险高4倍（女性传染男性的比率为每月每千人中有2.37人被传染）。

研究人员表示，这一数据和西方类似的研究有很大差异。在西方的研究中，女性向男性传染致癌性HPV的风险比男性传染给女性的更高。研究者认为，中国农村男女之间性保守度的差异可能是造成中外差异的原因，研究同时呼吁防治HPV的措施应该包括性活跃的年轻男性。

来源：中国科学报

作者: ipsvirus 时间: 2015-8-28 14:21
Transmission of genital human papillomavirus infection in couples: a population-based cohort study in rural China

Mengfei Liu, Zhonghu He, Chanyuan Zhang, Fangfang Liu, Ying Liu, Jingjing Li, Zhongyao Xu, Qiyan Wang, Dong Hang, Na Shen, Yaqi Pan, Chuanhai Guo, Hong Cai & Yang Ke

HPV transmission dynamics have rarely been studied in the general population, especially in China. We followed the genital HPV infection status of both partners in 874 couples aged 25-65 years from rural China for up to 7 bi-annual visits during 2009-2013. The positive HPV concordance and transmission rate for partners in a couple were evaluated and relevant risk factors were assessed. The concordance of any, oncogenic, and non-oncogenic HPV was 15.52%, 16.18% and 10.41%, respectively. Male-to-female transmission rate was 7.11, 12.13 and 4.77/1000 person months for any, oncogenic and non-oncogenic HPV respectively. The female-to-male transmission rate was 5.56, 2.37, and 17.01/1000 person months for any, oncogenic and non-oncogenic HPV respectively. The risk of male-to-female transmission was significantly higher than that of female-to-male transmission for oncogenic types. However, for non-oncogenic types, the risk of male-to-female transmission was significantly lower than that of female-to-male transmission. Younger couples, persistent infection with HPV, higher numbers of sexual partners and higher frequency of sexual intercourse were positively associated with HPV transmission in couples. Our results indicate that men in rural China play a more important role than men in western populations as a source of cervical oncogenic HPV infection in women.

http://www.nature.com/articles/srep10986

欢迎光临中国病毒学论坛|我们一直在坚持！ (http://bbs.virology.com.cn/)