Science. 2012 Feb 23. [Epub ahead of print]
Seroevidence for H5N1 Influenza Infections in Humans: Meta-Analysis.Wang TT, Parides MK, Palese P.
SourceDepartment of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA.
AbstractThe prevalence of avian H5N1 influenza A infections in humans has not been definitively determined. Cases of H5N1 infection in humans confirmed by the World Health Organization (WHO) are fewer than 600 in number, with an overall case fatality rate of >50%. We hypothesize that the stringent criteria for confirmation of a human case of H5N1 by WHO does not account for a majority of infections, but rather, the select few hospitalized cases that are more likely to be severe and result in poor clinical outcome. Meta-analysis shows that 1 to 2% of more than 12,500 study participants from 20 studies had seroevidence for prior H5N1 infection. http://www.ncbi.nlm.nih.gov/pubmed/22362880
该研究起源于前一段时间关于一个实验结果的讨论。实验研究发现，经过一些基因变异，H5N1病毒可在空气中存活并在哺乳动物如雪貂中自由传播。研究分别由来自荷兰Erasmus医学中心的Ron Fouchier和威斯康星大学麦迪逊分校的Yoshihiro Kawaoka领导。就此研究结果，一些专家呼吁暂缓研究或限制相关数据的发表(Fouchier和Kawaoka的论文分别发表在Science 和 Nature上)。他们认为，一些不法之徒可能会利用这些数据研制出危险的生化武器。另一些人认为研究应该被发表，以便让更多的人了解病毒如何通过基因变异转化为更为危险的形式。 作者: rojjer 时间: 2015-8-29 08:30
MBio. 2012 Mar 6;3(2). pii: e00049-12. doi: 10.1128/mBio.00049-12. Print 2012.
Working Safely with H5N1 Viruses.
García-Sastre A.
Source
Department of Microbiology, Department of Medicine, Division of Infectious Diseases, Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York, USA.
Abstract
ABSTRACT Research on H5N1 influenza viruses has received much attention recently due to the possible dangers associated with newly developed avian H5N1 viruses that were derived from highly pathogenic avian viruses and are now transmissible among ferrets via respiratory droplets. An appropriate discussion, based on scientific facts about the risks that such viruses pose and on the biocontainment facilities and practices necessary for working safely with these viruses, is needed. Selecting the right level of biocontainment is critical for minimizing the risks associated with H5N1 research while simultaneously allowing an appropriately fast pace of discovery. Rational countermeasures for preventing the spread of influenza can be developed only by gaining a thorough knowledge of the molecular mechanisms at work in host specificity and transmission.