看下面的图，来自
Nagaya, T., et al. , The mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma. Genes & development, 1987. 1(8): p. 773-782.
解说：
Figure 1. Structure of the integrated HBV sequences. At the top of the figure, the whole HBV genome is represented. The long thin line shows the minus strand with the DNA-linked protein (0), the short thin line represents the plus strand. The length of the HBV genome is indicated in kilobases, numbering from the hypothetical EcoRI site of sybtype adr (Ono et al. 1983; Fujiyama et al. 1983).
Open reading frames and their direction of transcription are represented by filled arrows. (S) HBsAg (preS), pre-S region; (C) HBcAg; (X) X gene. The P gene is omitted for clarity. DR1, DR2 are the 11-bp direct repeats whose starting points are 1590 and 1824, respectively. The region in between DR1 and DR2 is the cohesive end region. HBV genome regions that are covered by the integrated virus DNA are shown by solid bars. The virus DNA that has one continuous portion(s) of a circular HBV genome is represented by a single solid bar aligned in the same level. Deletions in the genome are represented by dotted lines. The complex-type virus DNA that consists of two or more HBV genomes whose regions are overlapping, at least in part, is represented by multiple solid bars aligned in different levels, each representing different units of the virus genome, and connected by tilted dotted lines. Solid thin lines represent flanking human DNA. Encircled numerals show the number of the human chromosome in which the flanking DNA was assigned (see text). L indicates that the cloning vector is directly joined to the virus DNA. Alu and Satellite III indicate that the cell DNA at the junction is homologous to either Alu repeating sequence or Satellite III sequence, respectively. 作者: cao1976 时间: 2015-8-29 09:02
bigben发表于 2009-7-25 02:35
Distribution of the viral integration sites on the chromosome map
Target genes searched by viral insertion
来自
Murakami, Y., et al. , Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas. Gut, 2005. 54(8): p. 1162-8. 作者: cao1976 时间: 2015-8-29 09:02
davay发表于 2009-7-25 13:01 ：正是我要的，非常感谢。作者: cao1976 时间: 2015-8-29 09:03
davay发表于 2009-7-25 13:01 ：正是我要的，非常感谢。作者: cao1976 时间: 2015-8-29 09:03
emma0802发表于 2010-6-20 20:21 ：
