ACAM-FLU-A™ is a recombinant vaccine that uses a hepatitis B core protein (HBc) to present M2e, the extracellular domain of the ion channel protein M2(5). M2 is one of the three proteins expressed on the surface of the ‘A' strain influenza virus and of infected cells alongside haemagglutinin (HA) and neuraminidase (NA). Unlike HA and NA, M2 is highly conserved, albeit under natural conditions not easily recognised by the immune system. M2e could elicit an immune response to all influenza ‘A' strains. As such, ACAM-FLU-A™ has the potential to be both a universal pandemic or pre-pandemic influenza vaccine and part of a universal seasonal vaccine. Historically, influenza pandemics have been caused by ‘A' strains of the virus while seasonal vaccines target both ‘A' and ‘B' strains of the virus.作者: ms003 时间: 2015-9-11 14:52
Rojjer发表于 2008-1-6 13:42
Background:Universal Influenza Vaccine
The M2 Protein abc：
1，A tetrameric type III interal membrane protein (97 Aa）
2，It has a short ectodomain (N-24Aa), a transmembrane domain (25-43), and an endodomain(C-54）
3，There is a high expression of M2 in the surface of virus- infected cells
4，Possess ion channel activity ,and a role for M2 in assembly and budding (some other functions）
5，Maintains a highly conserved sequence over long periods of time .（1918-2005）
6,M2e-specific Abs have been shown to display significant protective activity in animal models: homologous and heterosubtypic viruses challenge
M2 vaccine candidates that have been explored include peptide-carrier conjugates , baculovirus-expressed M2 , fusion proteins , multiple antigenic peptides , and M DNA constructs that potentially express M2 .不过个人认为：针对表面保守蛋白M2胞外区（M2e)的疫苗应该和针对中和抗原HA疫苗联合使用会更好，毕竟HA抗体是流感病毒诱导产生的唯一的中和抗体，其在预防流感病毒感染中的作用是无法代替的哦！