根据现有知识，某些病毒可以致癌，比如乙肝病毒会导致肝癌，人乳头状瘤病毒可引发宫颈癌和肛门癌。针对这两种病毒研发的疫苗已被用来预防相关癌症。比林教授说，假如牛白血病病毒被证明可导致乳腺癌，就有可能改变现在防控乳腺癌的一些做法。 作者: bigben446 时间: 2016-2-18 11:19
【标题】：Exposure to Bovine Leukemia Virus Is Associated with Breast Cancer: A Case-Control Study
【作者】：Buehring, G. C.; Shen, H. M.; Jensen, H. M. (...)
【来源】：PLoS One, 2015, 10(9), e134304
【摘要】：BACKGROUND: Age, reproductive history, hormones, genetics, and lifestyle are known risk factors for breast cancer, but the agents that initiate cellular changes from normal to malignant are not understood. We previously detected bovine leukemia virus (BLV), a common oncogenic virus of cattle, in the breast epithelium of humans. The objective of this study was to determine whether the presence of BLV DNA in human mammary epithelium is associated with breast cancer. METHODS: This was a case-control study of archival formalin fixed paraffin embedded breast tissues from 239 donors, received 2002-2008 from the Cooperative Human Tissue Network. Case definition as breast cancer versus normal (women with no history of breast cancer) was established through medical records and examination of tissues by an anatomical pathologist. Breast exposure to BLV was determined by in situ-PCR detection of a biomarker, BLV DNA, localized within mammary epithelium. RESULTS: The frequency of BLV DNA in mammary epithelium from women with breast cancer (59%) was significantly higher than in normal controls (29%) (multiply- adjusted odds ratio = 3.07, confidence interval = 1.66-5.69, p = .0004, attributable risk = 37%). In women with premalignant breast changes the frequency of BLV DNA was intermediate (38%) between that of women with breast cancer and normal controls (p for trend < .001). CONCLUSIONS: Among the specimens in this study, the presence of amplified BLV DNA was significantly associated with breast cancer. The odds ratio magnitude was comparable to those of well-established breast cancer risk factors related to reproductive history, hormones, and lifestyle and was exceeded only by risk factors related to genetics (familial breast cancer), high dose ionizing radiation, and age. These findings have the potential for primary and secondary prevention of breast cancer.