Rapid progress in the definition of tumour antigens, and improved immunization methods,
bring effective cancer vaccines within reach. In this wide-ranging survey, clinicians and scientists
at the forefront of these developments review therapeutic cancer vaccine strategies against a
variety of diseases and molecular targets.
Intended for an interdisciplinary readership, chapters cover the rationale, development and
implementation of vaccines in human cancers generally, and with specific reference to cancer
of the cervix, breast, colon, bladder and prostate, and to melanoma and lymphoma. Target
identification, delivery vectors and clinical trial design are reviewed, and the book begins and
ends with lucid overviews from the editors, including the most recent developments.
Encapsulating recent scientific progress and the likely clinical potential of cancer vaccines, this
book provides an essential introduction and guide for oncologists, immunologists and, indeed,
all clinicians treating cancer patients.
Peter Stern is Head of the Cancer Research Campaign Immunology Group at the Paterson
Institute for Cancer Research in Manchester.
Peter Beverley is Professor of Tumour Immunology at University College London, and also
Scientific Head and Chief Executive of the Edward Jenner Institute for Vaccine Research, at
Compton, Berkshire.
Miles Carroll is Programme Leader, Tumour Immunotherapy, at Oxford BioMedica (UK) Ltd.
目录
Contents
List of contributors vii
1 Immunity and cancer 1
Peter C.L. Beverley, Miles W. Carroll and Peter L. Stern
2 Immunotherapy of bladder cancer 19
Anton B. Alexandroff and Keith James
3 Poxviruses as vectors for cancer immunotherapy 47
Miles W. Carroll and Nicholas P. Restifo
4 Vaccinia-based human papillomavirus vaccines in cervical cancer 62
Leszek K. Borysiewicz and Stephen Man
5 Vaccine delivery and immunosuppression in cervical cancer 82
Michael P. Rudolf, Laurie A. Small, Markwin P. Velders, Diane M. DaSilva, Sanne Weijzen
and W. Martin Kast
6 Vaccines for colon cancer 107
Howard L. Kaufman and Jeffrey Schlom
7 MUC1 vaccines and breast cancer 135
Joyce Taylor-Papadimitriou, Joy Burchell and David W. Miles
8 Anti-idiotypic vaccination 162
Lindy G. Durrant, Ian Spendlove and R. Adrian Robins
9 Immunotherapy and vaccination against Epstein–Barr virus-associated
cancer 174
John R. Arrand
10 Serologically identified tumour antigens as cancer vaccines 195
Ugur Sahin, Özlem Türeci and Michael Pfreundschuh
11 CTL-defined cancer vaccines in melanoma and other epithelial cancers 207
Elke Jäger, Dirk Jäger and Alexander Knuth
12 DNA vaccines against B-cell tumours 218
Freda K. Stevenson, Delin Zhu, Myfanwy Spellerberg, Catherine A. King, Surinder S. Sahota,
Jason Rice, Andrew R. Thompsett and Terry J. Hamblin
13 Dendritic cell approaches to immunotherapy 237
Malcolm Adams, Bharat Jasani, Camilo A.L.S. Colaco and Malcolm D. Mason
14 Overview 256
Peter L. Stern, Peter C.L. Beverley and Miles W. Carroll
15 Recent developments 268作者: hantavirus 时间: 2015-10-9 09:04
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