miR-29抗HIV-1作用在08和09年就有报道，发现miR-29能够靶向nef和3‘UTR区域，影响病毒蛋白表达和病毒产生。

Retrovirology. 2008 Dec 23;5:117. doi: 10.1186/1742-4690-5-117.
Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication.
Ahluwalia JK1, Khan SZ, Soni K, Rawat P, Gupta A, Hariharan M, Scaria V, Lalwani M, Pillai B, Mitra D, Brahmachari SK.

Mol Cell. 2009 Jun 26;34(6):696-709. doi: 10.1016/j.molcel.2009.06.003.
Cellular microRNA and P bodies modulate host-HIV-1 interactions.
Nathans R1, Chu CY, Serquina AK, Lu CC, Cao H, Rana TM.

IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection

Stanley Adoro,        Juan R. Cubillos-Ruiz,        Xi Chen,        Maud Deruaz,        Vladimir D. Vrbanac,        Minkyung Song,        Suna Park,        Thomas T. Murooka,        Timothy E. Dudek,        Andrew D. Luster,        Andrew M. Tager,        Hendrik Streeck,        Brittany Bowman,        Bruce D. Walker,        Douglas S. Kwon,        Vanja Lazarevic        & Laurie H. Glimcher

Initial events after exposure determine HIV-1 disease progression, underscoring a critical need to understand host mechanisms that interfere with initial viral replication. Although associated with chronic HIV-1 control, it is not known whether interleukin-21 (IL-21) contributes to early HIV-1 immunity. Here we take advantage of tractable primary human lymphoid organ aggregate cultures to show that IL-21 directly suppresses HIV-1 replication, and identify microRNA-29 (miR-29) as an antiviral factor induced by IL-21 in CD4 T cells. IL-21 promotes transcription of all miR-29 species through STAT3, whose binding to putative regulatory regions within the MIR29 gene is enriched by IL-21 signalling. Notably, exogenous IL-21 limits early HIV-1 infection in humanized mice, and lower viremia in vivo is associated with higher miR-29 expression. Together, these findings reveal a novel antiviral IL-21-miR-29 axis that promotes CD4 T-cell-intrinsic resistance to HIV-1 infection, and suggest a role for IL-21 in initial HIV-1 control in vivo.

http://www.nature.com/ncomms/201 ... /ncomms8562.html#f4