Hans Will，汉堡，德国——HBV相关实验室及人物介绍系列

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Hans Will，汉堡，德国——HBV相关实验室及人物介绍系列

Geipel, A. and D. Glebe, et al. (2014). "Hepatitis B virus rtI233V mutation and resistance to adefovir." N Engl J Med 370(17): 1667-8.
Bhoola, N. H. and K. Reumann, et al. (2014). "Construction of replication competent plasmids of hepatitis B virus subgenotypes  A1, A2 and D3 with authentic endogenous promoters." J Virol Methods 203: 54-64.
Raimondo, G. and J. P. Allain, et al. (2008). "Statements from the Taormina expert meeting on occult hepatitis B virus infection." J Hepatol 49(4): 652-7.
Mhamdi, M. and A. Funk, et al. (2007). "Assembly and budding of a hepatitis B virus is mediated by a novel type of intracellular vesicles." Hepatology 46(1): 95-106.
Matthes, E. and A. Funk, et al. (2007). "Strong and selective inhibitors of hepatitis B virus replication among novel N4-hydroxy- and 5-methyl-beta-L-deoxycytidine analogues." Antimicrob Agents Chemother 51(7): 2523-30.
Funk, A. and M. Mhamdi, et al. (2007). "Avian hepatitis B viruses: molecular and cellular biology, phylogenesis, and host tropism." World J Gastroenterol 13(1): 91-103.
Schildgen, O. and H. Sirma, et al. (2006). "Variant of hepatitis B virus with primary resistance to adefovir." N Engl J Med 354(17): 1807-12.
Stoeckl, L. and A. Funk, et al. (2006). "Identification of a structural motif crucial for infectivity of hepatitis B viruses." Proc Natl Acad Sci U S A 103(17): 6730-4.
Heise, T. and G. Sommer, et al. (2006). "The hepatitis B virus PRE contains a splicing regulatory element." Nucleic Acids Res 34(1): 353-63.
Friedrich, B. and M. Wollersheim, et al. (2005). "Induction of anti-proliferative mechanisms in hepatitis B virus producing cells." J Hepatol 43(4): 696-703.
Lin, L. and A. Prassolov, et al. (2005). "Evidence from nature: interspecies spread of heron hepatitis B viruses." J Gen Virol 86(Pt 5): 1335-42.
Chang, S. F. and S. H. Chang, et al. (2004). "Characterization of nonconventional hepatitis B viruses lacking the core promoter." Virology 330(2): 437-46.
Ehlers, I. and S. Horke, et al. (2004). "Functional characterization of the interaction between human La and hepatitis B virus RNA." J Biol Chem 279(42): 43437-47.
Funk, A. and M. Mhamdi, et al. (2004). "Itinerary of hepatitis B viruses: delineation of restriction points critical for  infectious entry." J Virol 78(15): 8289-300.
Funk, A. and H. Hohenberg, et al. (2004). "Spread of hepatitis B viruses in vitro requires extracellular progeny and may be  codetermined by polarized egress." J Virol 78(8): 3977-83.
Meier, P. and C. A. Scougall, et al. (2003). "A duck hepatitis B virus strain with a knockout mutation in the putative X ORF shows similar infectivity and in vivo growth characteristics to wild-type virus." Virology 317(2): 291-8.
Kalinina, T. and A. Iwanski, et al. (2003). "Deficiency in virion secretion and decreased stability of the hepatitis B virus immune escape mutant G145R." Hepatology 38(5): 1274-81.
Kalinina, T. and A. Riu, et al. (2003). "Selection of a secretion-incompetent mutant in the serum of a patient with severe hepatitis B." Gastroenterology 125(4): 1077-84.
Prassolov, A. and H. Hohenberg, et al. (2003). "New hepatitis B virus of cranes that has an unexpected broad host range." J Virol 77(3): 1964-76.
Rang, A. and M. Bruns, et al. (2002). "Antiviral activity of interferon-alpha against hepatitis B virus can be studied in non-hepatic cells and Is independent of MxA." J Biol Chem 277(10): 7645-7.
Kalinina, T. and A. Riu, et al. (2001). "A dominant hepatitis B virus population defective in virus secretion because of several S-gene mutations from a patient with fulminant hepatitis." Hepatology 34(2): 385-94.
Dandri, M. and M. R. Burda, et al. (2001). "Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus." Hepatology 33(4): 981-8.
Chang, S. F. and H. J. Netter, et al. (2001). "Duck hepatitis B virus expresses a regulatory HBx-like protein from a hidden open reading frame." J Virol 75(1): 161-70.
Rang, A. and T. Heise, et al. (2001). "Lack of a role of the interferon-stimulated response element-like region in interferon alpha -induced suppression of Hepatitis B virus in vitro." J Biol Chem 276(5): 3531-5.
Burda, M. R. and S. Gunther, et al. (2001). "Structural and functional heterogeneity of naturally occurring hepatitis B virus  variants." Antiviral Res 52(2): 125-38.
Gunther, S. and N. Piwon, et al. (2000). "Enhanced replication contributes to enrichment of hepatitis B virus with a deletion in the core gene." Virology 273(2): 286-99.
Dandri, M. and M. R. Burda, et al. (2000). "Increased hepatocyte turnover and inhibition of woodchuck hepatitis B virus replication by adefovir in vitro do not lead to reduction of the closed circular  DNA." Hepatology 32(1): 139-46.
Sommer, G. and F. van Bommel, et al. (2000). "Genotype-specific synthesis and secretion of spliced hepatitis B virus genomes in hepatoma cells." Virology 271(2): 371-81.
Rang, A. and S. Gunther, et al. (1999). "Effect of interferon alpha on hepatitis B virus replication and gene expression in transiently transfected human hepatoma cells." J Hepatol 31(5): 791-9.
Preikschat, P. and H. Meisel, et al. (1999). "Hepatitis B virus genomes from long-term immunosuppressed virus carriers are modified by specific mutations in several regions." J Gen Virol 80 ( Pt 10): 2685-91.
Gunther, S. and L. Fischer, et al. (1999). "Naturally occurring variants of hepatitis B virus." Adv Virus Res 52: 25-137.
Gunther, S. and F. von Breunig, et al. (1999). "Absence of mutations in the YMDD motif/B region of the hepatitis B virus polymerase in famciclovir therapy failure." J Hepatol 30(5): 749-54.
Fischer, L. and M. Sterneck, et al. (1999). "Hepatitis B virus variants associated with clinically severe recurrence after liver transplantation." Transplant Proc 31(1-2): 492-3.
Sunyach, C. and C. Rollier, et al. (1999). "Residues critical for duck hepatitis B virus neutralization are involved in host  cell interaction." J Virol 73(4): 2569-75.
Bruns, M. and S. Miska, et al. (1998). "Enhancement of hepatitis B virus infection by noninfectious subviral particles." J Virol 72(2): 1462-8.
Sterneck, M. and T. Kalinina, et al. (1998). "Functional analysis of HBV genomes from patients with fulminant hepatitis." Hepatology 28(5): 1390-7.
Altfeld, M. and J. K. Rockstroh, et al. (1998). "Reactivation of hepatitis B in a long-term anti-HBs-positive patient with AIDS following lamivudine withdrawal." J Hepatol 29(2): 306-9.
Sterneck, M. and T. Kalinina, et al. (1998). "Neonatal fulminant hepatitis B: structural and functional analysis of complete hepatitis B virus genomes from mother and infant." J Infect Dis 177(5): 1378-81.
Gunther, S. and W. Paulij, et al. (1998). "Analysis of hepatitis B virus populations in an interferon-alpha-treated patient  reveals predominant mutations in the C-gene and changing e-antigenicity." Virology 244(1): 146-60.
Gunther, S. and N. Piwon, et al. (1998). "Wild-type levels of pregenomic RNA and replication but reduced pre-C RNA and e-antigen synthesis of hepatitis B virus with C(1653) --> T, A(1762) --> T and G(1764) --> A mutations in the core promoter." J Gen Virol 79 ( Pt 2): 375-80.
Gunther, S. and G. Sommer, et al. (1998). "Amplification of full-length hepatitis B virus genomes from samples from patients with low levels of viremia: frequency and functional consequences of PCR-introduced mutations." J Clin Microbiol 36(2): 531-8.
Elmore, L. W. and A. R. Hancock, et al. (1997). "Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis." Proc Natl Acad Sci U S A 94(26): 14707-12.
Sommer, G. and S. Gunther, et al. (1997). "A new class of defective hepatitis B virus genomes with an internal poly(dA) sequence." Virology 239(2): 402-12.
Gunther, S. and G. Sommer, et al. (1997). "Heterogeneity and common features of defective hepatitis B virus genomes derived  from spliced pregenomic RNA." Virology 238(2): 363-71.
Gunther, S. and G. Sommer, et al. (1997). "Naturally occurring hepatitis B virus genomes bearing the hallmarks of retroviral G-->A hypermutation." Virology 235(1): 104-8.
Naoumov, N. V. and K. A. Antonov, et al. (1997). "Differentiation of core gene products of the hepatitis B virus in infected liver  tissue using monoclonal antibodies." J Med Virol 53(2): 127-38.
Netter, H. J. and S. Chassot, et al. (1997). "Sequence heterogeneity of heron hepatitis B virus genomes determined by full-length DNA amplification and direct sequencing reveals novel and unique features." J Gen Virol 78 ( Pt 7): 1707-18.
Sterneck, M. and S. Gunther, et al. (1997). "Hepatitis B virus sequence changes evolving in liver transplant recipients with fulminant hepatitis." J Hepatol 26(4): 754-64.
Reinke, P. and S. Baginski, et al. (1997). "Association between the accumulation of hepatitis B virus core gene deletion mutants and progression of liver disease in long-term renal transplant patients." Transplant Proc 29(1-2): 815-6.
Gunther, S. and N. Piwon, et al. (1996). "Type, prevalence, and significance of core promoter/enhancer II mutations in hepatitis B viruses from immunosuppressed patients with severe liver disease." J Virol 70(12): 8318-31.
Gunther, S. and S. Baginski, et al. (1996). "Accumulation and persistence of hepatitis B virus core gene deletion mutants in renal transplant patients are associated with end-stage liver disease." Hepatology 24(4): 751-8.
Sterneck, M. and S. Gunther, et al. (1996). "Hepatitis B virus genomes of patients with fulminant hepatitis do not share a specific mutation." Hepatology 24(2): 300-6.
Marinos, G. and F. Torre, et al. (1996). "Hepatitis B virus variants with core gene deletions in the evolution of chronic hepatitis B infection." Gastroenterology 111(1): 183-92.
Gunther, S. and B. C. Li, et al. (1995). "A novel method for efficient amplification of whole hepatitis B virus genomes permits rapid functional analysis and reveals deletion mutants in immunosuppressed patients." J Virol 69(9): 5437-44.
Jung, M. C. and H. M. Diepolder, et al. (1995). "Activation of a heterogeneous hepatitis B (HB) core and e antigen-specific CD4+ T-cell population during seroconversion to anti-HBe and anti-HBs in hepatitis B virus infection." J Virol 69(6): 3358-68.
Carlier, D. and O. Jean-Jean, et al. (1995). "Importance of the C terminus of the hepatitis B virus precore protein in secretion of HBe antigen." J Gen Virol 76 ( Pt 4): 1041-5.
Gunther, S. and S. Miska, et al. (1995). "Structure and selection of hepatitis B virus variants during the natural course of infection and interferon therapy." Princess Takamatsu Symp 25: 211-20.
Miska, S. and S. Gunther, et al. (1993). "Heterogeneity of hepatitis B virus C-gene sequences: implications for amplification and sequencing." J Hepatol 18(1): 53-61.
Santantonio, T. and M. C. Jung, et al. (1993). "Prevalence of wildtype and pre-C HBV variants in HBsAg/anti-HBe positive carriers with chronic hepatitis delta virus infection." Prog Clin Biol Res 382: 235-42.
Schodel, F. and G. Neckermann, et al. (1993). "Immunization with recombinant woodchuck hepatitis virus nucleocapsid antigen or hepatitis B virus nucleocapsid antigen protects woodchucks from woodchuck hepatitis virus infection." Vaccine 11(6): 624-8.
Santantonio, T. and M. C. Jung, et al. (1993). "Long-term response to interferon therapy in chronic hepatitis B: importance of hepatitis B virus heterogeneity." Arch Virol Suppl 8: 171-8.
Miska, S. and H. Will (1993). "Hepatitis B virus C-gene variants." Arch Virol Suppl 8: 155-69.
Fernholz, D. and G. Wildner, et al. (1993). "Minor envelope proteins of duck hepatitis B virus are initiated at internal pre-S AUG codons but are not essential for infectivity." Virology 197(1): 64-73.
Fernholz, D. and P. R. Galle, et al. (1993). "Infectious hepatitis B virus variant defective in pre-S2 protein expression in a  chronic carrier." Virology 194(1): 137-48.
McGlynn, E. and S. Reutener, et al. (1992). "Hepatitis B virus polymerase gene: expression of the long open reading frame using the baculovirus expression system." J Gen Virol 73 ( Pt 6): 1515-9.
Santantonio, T. and M. C. Jung, et al. (1992). "Hepatitis B virus genomes that cannot synthesize pre-S2 proteins occur frequently and as dominant virus populations in chronic carriers in Italy." Virology 188(2): 948-52.
Matthes, E. and M. von Janta-Lipinski, et al. (1992). "Inhibition of hepatitis B virus production by modified 2',3'-dideoxy-thymidine and 2',3'-dideoxy-5-methylcytidine derivatives. In vitro and in vivo studies." Biochem Pharmacol 43(7): 1571-7.
Grotzinger, T. and H. Will (1992). "Sensitive method for identification of minor hepatitis B mutant viruses." Virology 187(1): 383-7.
Naoumov, N. V. and R. Schneider, et al. (1992). "Precore mutant hepatitis B virus infection and liver disease." Gastroenterology 102(2): 538-43.
Avantaggiati, M. L. and C. Balsano, et al. (1992). "The hepatitis B virus X protein transactivation of c-fos and c-myc proto-oncogenes is mediated by multiple transcription factors." Arch Virol Suppl 4: 57-61.
Schodel, F. and A. M. Moriarty, et al. (1992). "The position of heterologous epitopes inserted in hepatitis B virus core particles determines their immunogenicity." J Virol 66(1): 106-14.
Schodel, F. and H. Will, et al. (1991). "Synthesis in Vibrio cholerae and secretion of hepatitis B virus antigens fused to Escherichia coli heat-labile enterotoxin subunit B." Gene 99(2): 255-9.
Will, H. (1991). "The X-protein of hepatitis B virus. Facts and fiction." J Hepatol 13 Suppl 4: S56-7.
Fernholz, D. and M. Stemler, et al. (1991). "Replicating and virion secreting hepatitis B mutant virus unable to produce preS2 protein." J Hepatol 13 Suppl 4: S102-4.
Levrero, M. and C. Balsano, et al. (1991). "Hepatitis B virus and hepatocellular carcinoma: a possible role for the viral transactivators." Ital J Gastroenterol 23(9): 576-83.
Santantonio, T. and M. C. Jung, et al. (1991). "Selection for a pre-C stop codon mutation in a hepatitis B virus variant with a pre-C initiation codon mutation during interferon treatment." J Hepatol 13(3): 368-71.
Schneider, R. and H. Will (1991). "Regulatory sequences of duck hepatitis B virus C gene transcription." J Virol 65(11): 5693-701.
Schneider, R. and D. Fernholz, et al. (1991). "Mechanism, kinetics, and role of duck hepatitis B virus e-antigen expression in vivo." Virology 182(2): 503-12.
Brunetto, M. R. and M. M. Giarin, et al. (1991). "Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis." Proc Natl Acad Sci U S A 88(10): 4186-90.
Balsano, C. and M. L. Avantaggiati, et al. (1991). "Full-length and truncated versions of the hepatitis B virus (HBV) X protein (pX)  transactivate the cmyc protooncogene at the transcriptional level." Biochem Biophys Res Commun 176(3): 985-92.
Bonino, F. and M. R. Brunetto, et al. (1991). "Hepatitis B virus unable to secrete e antigen." Gastroenterology 100(4): 1138-41.
Lambert, V. and D. Fernholz, et al. (1990). "Virus-neutralizing monoclonal antibody to a conserved epitope on the duck hepatitis B virus pre-S protein." J Virol 64(3): 1290-7.
Levrero, M. and O. Jean-Jean, et al. (1990). "Hepatitis B virus (HBV) X gene expression in human cells and anti-HBx antibodies  detection in chronic HBV infection." Virology 174(1): 299-304.
Brunetto, M. R. and M. Stemler, et al. (1990). "A new hepatitis B virus strain in patients with severe anti-HBe positive chronic  hepatitis B." J Hepatol 10(2): 258-61.
Schodel, F. and D. R. Milich, et al. (1990). "Hepatitis B virus nucleocapsid/pre-S2 fusion proteins expressed in attenuated Salmonella for oral vaccination." J Immunol 145(12): 4317-21.
Schodel, F. and G. Enders, et al. (1990). "Recognition of a hepatitis B virus nucleocapsid T-cell epitope expressed as a fusion protein with the subunit B of Escherichia coli heat labile enterotoxin in  attenuated salmonellae." Vaccine 8(6): 569-72.
Raimondo, G. and M. Stemler, et al. (1990). "Latency and reactivation of a precore mutant hepatitis B virus in a chronically infected patient." J Hepatol 11(3): 374-80.
Raimondo, G. and R. Schneider, et al. (1990). "A new hepatitis B virus variant in a chronic carrier with multiple episodes of viral reactivation and acute hepatitis." Virology 179(1): 64-8.
Weimer, T. and F. Schodel, et al. (1990). "Antibodies to the RNase H domain of hepatitis B virus P protein are associated with ongoing viral replication." J Virol 64(11): 5665-8.
Matthes, E. and P. Langen, et al. (1990). "Potent inhibition of hepatitis B virus production in vitro by modified pyrimidine nucleosides." Antimicrob Agents Chemother 34(10): 1986-90.
Schodel, F. and H. Will (1990). "Expression of hepatitis B virus antigens in attenuated Salmonellae for oral immunization." Res Microbiol 141(7-8): 831-7.
Jochum, C. and R. Voth, et al. (1990). "Immunosuppressive function of hepatitis B antigens in vitro: role of endoribonuclease V as one potential trans inactivator for cytokines in macrophages and human hepatoma cells." J Virol 64(5): 1956-63.
Stemler, M. and T. Weimer, et al. (1990). "Mapping of B-cell epitopes of the human hepatitis B virus X protein." J Virol 64(6): 2802-9.
Jean-Jean, O. and T. Weimer, et al. (1989). "Internal entry of ribosomes and ribosomal scanning involved in hepatitis B virus  P gene expression." J Virol 63(12): 5451-4.
Abraham, R. and H. W. Doerr, et al. (1989). "Antibodies to hepatitis B virus x-protein in sera of patients with acute and chronic active hepatitis." Med Microbiol Immunol 178(4): 187-97.
Jean-Jean, O. and M. Levrero, et al. (1989). "Expression mechanism of the hepatitis B virus (HBV) C gene and biosynthesis of HBe antigen." Virology 170(1): 99-106.
Weimer, T. and K. Weimer, et al. (1989). "Immunogenicity of human hepatitis B virus P-gene derived proteins." J Immunol 143(11): 3750-6.
Liang, X. H. and M. Stemler, et al. (1988). "Low incidence and high titers of antibodies to hepatitis B virus X-protein in sera of Chinese patients with hepatocellular carcinoma." J Med Virol 25(3): 329-37.
Sprengel, R. and E. F. Kaleta, et al. (1988). "Isolation and characterization of a hepatitis B virus endemic in herons." J Virol 62(10): 3832-9.
Stemler, M. and J. Hess, et al. (1988). "Serological evidence for expression of the polymerase gene of human hepatitis B virus in vivo." J Gen Virol 69 ( Pt 3): 689-93.
Raimondo, G. and R. D. Burk, et al. (1988). "Interrupted replication of hepatitis B virus in liver tissue of HBsAg carriers with hepatocellular carcinoma." Virology 166(1): 103-12.
Hess, J. and M. Stemler, et al. (1988). "Frequent detection of antibodies to hepatitis B virus x-protein in acute, chronic and resolved infections." Med Microbiol Immunol 177(4): 195-205.
Will, H. and W. Reiser, et al. (1987). "Replication strategy of human hepatitis B virus." J Virol 61(3): 904-11.
Weimer, T. and J. Salfeld, et al. (1987). "Expression of the hepatitis B virus core gene in vitro and in vivo." J Virol 61(10): 3109-13.
Theilmann, L. and H. Will (1986). "[Hepatitis B virus infection: gene technology enriches diagnosis]." Wien Med Wochenschr 136(1-2): 41-2.
Will, H. and J. Salfeld, et al. (1986). "Putative reverse transcriptase intermediates of human hepatitis B virus in primary liver carcinomas." Science 231(4738): 594-6.
Asselbergs, F. A. and H. Will, et al. (1986). "A recombinant Chinese hamster ovary cell line containing a 300-fold amplified tetramer of the hepatitis B genome together with a double selection marker expresses high levels of viral protein." J Mol Biol 189(3): 401-11.
Gmelin, K. and L. Theilmann, et al. (1985). "Determination of HBV DNA in serum in a case of needlestick hepatitis." Z Gastroenterol 23(2): 60-3.
Will, H. and R. Cattaneo, et al. (1985). "Infectious hepatitis B virus from cloned DNA of known nucleotide sequence." Proc Natl Acad Sci U S A 82(3): 891-5.
Theilmann, L. and K. Gmelin, et al. (1985). "[Integrated and nonintegrated hepatitis B virus DNA in liver tissue]." Leber Magen Darm 15(2): 53-7.
Buscher, M. and W. Reiser, et al. (1985). "Transcripts and the putative RNA pregenome of duck hepatitis B virus: implications for reverse transcription." Cell 40(3): 717-24.
Sprengel, R. and C. Kuhn, et al. (1985). "Comparative sequence analysis of duck and human hepatitis B virus genomes." J Med Virol 15(4): 323-33.
Cattaneo, R. and H. Will, et al. (1984). "Hepatitis B virus transcription in the infected liver." EMBO J 3(9): 2191-6.
Sprengel, R. and C. Kuhn, et al. (1984). "Cloned duck hepatitis B virus DNA is infectious in Pekin ducks." J Virol 52(3): 932-7.
Gmelin, K. and L. Theilmann, et al. (1984). "[Anti-HBc IgM in acute and chronic hepatitis B virus infection]." Klin Wochenschr 62(17): 837-42.
Will, H. and R. Cattaneo, et al. (1984). "Expression of hepatitis B antigens with a simian virus 40 vector." J Virol 50(2): 335-42.
Theilmann, L. and K. Gmelin, et al. (1984). "Detection of hepatitis B viral DNA in sera positive for antibody to delta antigen." J Infect Dis 150(1): 118-20.
Will, H. and G. Darai, et al. (1983). "Hepatitis B after infection of a chimpanzee with cloned HBV DNA." Dev Biol Stand 54: 131-3.
Cattaneo, R. and H. Will, et al. (1983). "Signals regulating hepatitis B surface antigen transcription." Nature 305(5932): 336-8.
Will, H. and C. Kuhn, et al. (1982). "Structure and function of the hepatitis B virus genome." Princess Takamatsu Symp 12: 237-47.
Will, H. and R. Cattaneo, et al. (1982). "Cloned HBV DNA causes hepatitis in chimpanzees." Nature 299(5885): 740-2.