|
|
本帖最后由 randomqd 于 2016-8-16 12:20 编辑
" }& x- y) P" q' h V% H/ I$ e$ W5 E0 G, r
1st Edition. \9 S# c1 Y5 O4 R& t+ @
Authors: Joo Chuan Tong Shoba Ranganathan
% t7 E c) y) A2 U( zElectronic ISBN 9781908818416 Print ISBN 9781907568411# T% x+ r9 J# N5 r7 a0 N8 h: L
* r+ a% `; k" F# @. n
Description, t& I' R! F+ u
Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.
4 W% p9 @# x9 Q2 XComputer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.+ T( z& Q' V) b- Q( n
( K4 @( [! N- ^# H2 y$ T) G+ P5 `" Z. g
Table of Contents9 z5 {1 n5 i9 h) V9 ^5 z( w
List of figures
: P7 r- |8 u Q- F4 d8 ]8 f$ a. @List of abbreviations
3 k0 Q! x3 z e% [About the authors
) H: E/ O6 u1 g3 o& |" E( c: v \Preface9 G% X2 p2 W* m& m
Chapter 1: MHC and T cell responses2 P3 \# U' j) i! K1 E7 k
Abstract:
0 `4 x6 o$ T1 U% s1.1 Genetic organization of the MHC; T. ?' u. p& v+ }3 b
1.2 MHC structure) v. f4 @1 `9 `/ A5 D3 P3 b* ~" y
1.3 MHC function
& Z4 G2 M* h$ D% x$ Z1.4 Peptide binding
& V' f- _2 y" C& l% s; K3 s: m) SChapter 2: Immunoglobulins and B cell responses
# T& k: r% {# f" w" |9 g. oAbstract:
$ ~: N- ~9 [1 y) d a2.1 Types of immunoglobulins. l9 q! ^8 S$ I, Q8 J4 d1 b
2.2 Immunoglobulin structure p& V4 K6 i- h% ^# ]# Q
2.3 Immunoglobulin function. o" h9 _( B. N# f' o
2.4 Antigen binding
+ ?2 h- K( Q5 [4 |1 F- r, S0 b& MChapter 3: Scientific publications and databases4 f$ [: y/ j, l0 j# ?9 Q
Abstract:) d6 G, l8 w; B5 H. o, m- f4 V* W
3.1 Bibliographical information
# {" |& y# v2 Q3.2 Searching the literature8 F6 j: A, q8 u! C6 }- i
3.3 General databases containing information on genes and proteins+ w* \& G" ]( n; [
3.4 Immunological databases
; ?* t A- D, w J9 j x3.5 Small molecule databases7 X2 s% G3 E1 y/ D9 V) {4 w
Chapter 4: Database design
. B- t4 k5 ?6 L7 L) @Abstract:
- V4 m2 f L: X4.1 Fundamentals of database design* g3 k+ {/ q1 t
4.2 ER diagram
% a9 S# L7 V1 B' h( d0 \9 r4.3 Normalization and normal forms- e/ ?) E' |2 ?0 @: z- A+ \- H
Chapter 5: Computational T cell vaccine design
0 v6 F; V; y& E+ q; |Abstract:* L4 x* v3 j. X' G6 E
5.1 Sequence-based methods, f/ {' G6 L" Z. T# `2 ]+ u
5.2 Structure-based methods$ l" x' G7 @1 K7 r v; }
5.3 Broad-based T cell vaccine design
" X; k/ O% L/ E( lChapter 6: Computational B cell vaccine design
1 V5 b' @6 D3 @. |( g0 WAbstract:& S! s2 f7 k* e6 ^8 g' z! U
6.1 Sequence-based methods5 e7 L/ I* Z" q! ?. v* j$ b, D
6.2 Structure-based methods
( E4 v; h3 \4 n) Y' U, j- P4 ^5 UChapter 7: Infectious disease informatics
6 c% O% d+ J) F! C* _5 a- K/ uAbstract:/ }: v4 D* V4 A8 A0 ]9 d6 d- E' P9 m
7.1 Infectious diseases in history
* X8 g) g& E) o( ^5 z6 H7.2 Microbial sequence analysis. q* l5 R* j/ g* g
7.3 Detecting natural selection in molecular evolution
- w* C5 v) C4 LChapter 8: Vaccine safety and quality assessments u0 [9 w' a0 e) D
Abstract:
' I) w+ ^1 y' M( q8.1 Assessment of ADME/Tox deficiencies O) I: u# k/ k: _7 N
8.2 Assessment of allergenicity
& k4 K5 I9 t( k5 q9 DChapter 9: Vaccine adjuvant informatics! M# Q8 t# F; J3 Z; D, Z
Abstract:
$ W! L. e4 r7 V1 r+ h8 x0 J9.1 Virtual combinatorial library; C# a2 Z9 k0 I% e+ K3 k1 O9 ?3 E
9.2 Chemical file formats5 y2 B4 H/ [3 N4 w* w
9.3 Considerations for virtual library design
! c1 D( @$ c8 Y5 X) l. Y$ cIndex! k7 }9 L7 q, ]- x4 s, J; Z
" a0 G" f$ l. W9 c9 O) h& T
7 j2 I. }1 u! F, U/ f* W, M; d; z; U: b2 u
原文下载地址：$ b6 S5 K" b$ R. z* u
, m& I) E, L/ W7 T+ {" N; K" C
{' `: m( R, b& j |
本帖子中包含更多资源
您需要 登录 才可以下载或查看，没有帐号？立即注册
x
|
发表于 2016-8-16 12:18:44
QQ好友和群
QQ空间
腾讯微博
腾讯朋友
收藏
分享
支持
反对
发表于 2016-10-9 10:55:32
