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发表于 2015-11-30 21:48:48
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Adv Mater. 2015 Nov 26. doi: 10.1002/adma.201503740. [Epub ahead of print]
Vaccine Engineering with Dual-Functional Mineral Shell: A Promising Strategy to Overcome Preexisting Immunity.
Wang X1, Sun C2, Li P2, Wu T2, Zhou H3, Yang D4, Liu Y2, Ma X2, Song Z3, Nian Q4, Feng L2, Qin C4, Chen L2,5, Tang R1,3,6.
Author information
1Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, Zhejiang, 310027, P. R. China.
2State Key Laboratory of Respiratory Diseases, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, 510530, P. R. China.
3Center for Biomaterials and Biopathways, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027, P. R. China.
4State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, P. R. China.
5State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, P. R. China.
6State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou, 310027, P.R. China.
Abstract
Dual-functional biomineral-vaccine core-shell nanohybrids are obtained using recombinant adenovirus serotype 5 (rAd5) as templates, which efficiently mask the neutralizing epitope of vaccines and preserve their original immunogenicity. The versatile vaccine hybrid can evade the preexisting anti-Ad5 immunity, leading to boosted multifunctional antigen-specific cytokine-secreting T cell responses and presenting promising applications of vaccine-material hybrid for the rational design of vaccines.
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