Tomasz I. Michalak，纽芬兰，加拿大——HBV相关实验室及人物

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Tomasz I. Michalak，纽芬兰，加拿大——HBV相关实验室及人物介绍系列

Tomasz I. Michalak，Memorial University of Newfoundland 纽芬兰纪念大学, 加拿大

Mulrooney-Cousins, P. M. and T. I. Michalak (2015). "Asymptomatic Hepadnaviral Persistence and Its Consequences in the Woodchuck Model of Occult Hepatitis B Virus Infection." J Clin Transl Hepatol 3(3): 211-9.
Coffin, C. S. and P. M. Mulrooney-Cousins, et al. (2014). "Virological characteristics of occult hepatitis B virus in a North American cohort of human immunodeficiency virus type 1-positive patients on dual active anti-HBV/HIV therapy." J Clin Virol 60(4): 347-53.
Mulrooney-Cousins, P. M. and R. Chauhan, et al. (2014). "Primary seronegative but molecularly evident hepadnaviral infection engages liver and induces hepatocarcinoma in the woodchuck model of hepatitis B." PLoS Pathog 10(8): e1004332.
Gujar, S. A. and P. M. Mulrooney-Cousins, et al. (2013). "Repeated exposure to trace amounts of woodchuck hepadnavirus induces molecularly  evident infection and virus-specific T cell response in the absence of serological infection markers and hepatitis." J Virol 87(2): 1035-48.
Coffin, C. S. and P. M. Mulrooney-Cousins, et al. (2011). "Hepatitis B virus quasispecies in hepatic and extrahepatic viral reservoirs in liver transplant recipients on prophylactic therapy." Liver Transpl 17(8): 955-62.
Coffin, C. S. and P. M. Mulrooney-Cousins, et al. (2011). "Molecular characterization of intrahepatic and extrahepatic hepatitis B virus (HBV) reservoirs in patients on suppressive antiviral therapy." J Viral Hepat 18(6): 415-23.
Gujar, S. A. and A. K. Jenkins, et al. (2010). "Pre-acute hepadnaviral infection is associated with activation-induced apoptotic  death of lymphocytes in the woodchuck (Marmota monax) model of hepatitis B." Dev Comp Immunol 34(9): 999-1008.
Gujar, S. A. and T. I. Michalak (2009). "Primary occult hepadnavirus infection induces virus-specific T-cell and aberrant  cytokine responses in the absence of antiviral antibody reactivity in the Woodchuck model of hepatitis B virus infection." J Virol 83(8): 3861-76.
Michalak, T. I. and H. Zhang, et al. (2009). "Profound antiviral effect of oral administration of MIV-210 on chronic hepadnaviral infection in a woodchuck model of hepatitis B." Antimicrob Agents Chemother 53(9): 3803-14.
Gujar, S. A. and A. K. Jenkins, et al. (2008). "Aberrant lymphocyte activation precedes delayed virus-specific T-cell response after both primary infection and secondary exposure to hepadnavirus in the woodchuck model of hepatitis B virus infection." J Virol 82(14): 6992-7008.
Mulrooney-Cousins, P. M. and T. I. Michalak (2008). "Repeated passage of wild-type woodchuck hepatitis virus in lymphoid cells does not generate cell type-specific variants or alter virus infectivity." J Virol 82(15): 7540-50.
Coffin, C. S. and P. M. Mulrooney-Cousins, et al. (2007). "Profound suppression of chronic hepatitis C following superinfection with hepatitis B virus." Liver Int 27(5): 722-6.
Mulrooney-Cousins, P. M. and T. I. Michalak (2007). "Persistent occult hepatitis B virus infection: experimental findings and clinical implications." World J Gastroenterol 13(43): 5682-6.
Wang, J. and S. A. Gujar, et al. (2007). "Bicistronic woodchuck hepatitis virus core and gamma interferon DNA vaccine can protect from hepatitis but does not elicit sterilizing antiviral immunity." J Virol 81(2): 903-16.
Wang, J. and T. I. Michalak (2006). "Inhibition by woodchuck hepatitis virus of class I major histocompatibility complex presentation on hepatocytes is mediated by virus envelope pre-S2 protein  and can be reversed by treatment with gamma interferon." J Virol 80(17): 8541-53.
Gujar, S. A. and T. I. Michalak (2005). "Flow cytometric quantification of T cell proliferation and division kinetics in woodchuck model of hepatitis B." Immunol Invest 34(2): 215-36.
Churchill, N. D. and T. I. Michalak (2004). "Woodchuck hepatitis virus hepatocyte culture models." Methods Mol Med 96: 175-87.
Coffin, C. S. and T. N. Pham, et al. (2004). "Persistence of isolated antibodies to woodchuck hepatitis virus core antigen is indicative of occult infection." Hepatology 40(5): 1053-61.
Diao, J. and D. M. Slaney, et al. (2003). "Modulation of the outcome and severity of hepadnaviral hepatitis in woodchucks by antibodies to hepatic asialoglycoprotein receptor." Hepatology 38(3): 629-38.
Lew, Y. Y. and T. I. Michalak (2001). "In vitro and in vivo infectivity and pathogenicity of the lymphoid cell-derived woodchuck hepatitis virus." J Virol 75(4): 1770-82.
Hodgson, P. D. and T. I. Michalak (2001). "Augmented hepatic interferon gamma expression and T-cell influx characterize acute hepatitis progressing to recovery and residual lifelong virus persistence in experimental adult woodchuck hepatitis virus infection." Hepatology 34(5): 1049-59.
Michalak, T. I. (2000). "Occult persistence and lymphotropism of hepadnaviral infection: insights from the woodchuck viral hepatitis model." Immunol Rev 174: 98-111.
Michalak, T. I. and P. D. Hodgson, et al. (2000). "Posttranscriptional inhibition of class I major histocompatibility complex presentation on hepatocytes and lymphoid cells in chronic woodchuck hepatitis virus infection." J Virol 74(10): 4483-94.
Hodgson, P. D. and M. D. Grant, et al. (1999). "Perforin and Fas/Fas ligand-mediated cytotoxicity in acute and chronic woodchuck  viral hepatitis." Clin Exp Immunol 118(1): 63-70.
Coffin, C. S. and T. I. Michalak (1999). "Persistence of infectious hepadnavirus in the offspring of woodchuck mothers recovered from viral hepatitis." J Clin Invest 104(2): 203-12.
Michalak, T. I. and I. U. Pardoe, et al. (1999). "Occult lifelong persistence of infectious hepadnavirus and residual liver inflammation in woodchucks convalescent from acute viral hepatitis." Hepatology 29(3): 928-38.
Diao, J. and N. D. Churchill, et al. (1998). "Complement-mediated cytotoxicity and inhibition of ligand binding to hepatocytes  by woodchuck hepatitis virus-induced autoantibodies to asialoglycoprotein receptor." Hepatology 27(6): 1623-31.
Diao, J. and T. I. Michalak (1997). "Virus-induced anti-asialoglycoprotein receptor autoimmunity in experimental hepadnaviral hepatitis." Hepatology 25(3): 689-96.
Jin, Y. M. and N. D. Churchill, et al. (1996). "Protease-activated lymphoid cell and hepatocyte recognition site in the preS1 domain of the large woodchuck hepatitis virus envelope protein." J Gen Virol 77 ( Pt 8): 1837-46.
Michalak, T. I. and J. Y. Lau, et al. (1995). "Antibody-directed complement-mediated cytotoxicity to hepatocytes from patients with chronic hepatitis B." Clin Exp Immunol 100(2): 227-32.
Pardoe, I. U. and T. I. Michalak (1995). "Detection of hepatitis B and woodchuck hepatitis viral DNA in plasma and mononuclear cells from heparinized blood by the polymerase chain reaction." J Virol Methods 51(2-3): 277-88.
Michalak, T. I. and B. Lin (1994). "Molecular species of hepadnavirus core and envelope polypeptides in hepatocyte plasma membrane of woodchucks with acute and chronic viral hepatitis." Hepatology 20(2): 275-86.
Michalak, T. I. and C. Pasquinelli, et al. (1994). "Hepatitis B virus persistence after recovery from acute viral hepatitis." J Clin Invest 94(2): 907.
Michalak, T. I. and C. Pasquinelli, et al. (1994). "Hepatitis B virus persistence after recovery from acute viral hepatitis." J Clin Invest 93(1): 230-9.
Dzwonkowski, P. and T. I. Michalak (1990). "Autoantibody pattern in a woodchuck model of hepatitis B." Clin Invest Med 13(6): 322-8.
Michalak, T. I. and B. Lin, et al. (1990). "Hepadna virus nucleocapsid and surface antigens and the antigen-specific antibodies associated with hepatocyte plasma membranes in experimental woodchuck  acute hepatitis." Lab Invest 62(6): 680-9.
Michalak, T. I. and R. L. Snyder, et al. (1989). "Characterization of the incorporation of woodchuck hepatitis virus surface antigen into hepatocyte plasma membrane in woodchuck hepatitis and in the virus-induced hepatocellular carcinoma." Hepatology 10(1): 44-55.
Michalak, T. I. and N. D. Churchill (1988). "Interaction of woodchuck hepatitis virus surface antigen with hepatocyte plasma membrane in woodchuck chronic hepatitis." Hepatology 8(3): 499-506.