|
|
本帖最后由 randomqd 于 2016-8-16 12:20 编辑
R! ^5 J$ m: t! a, z7 A @, O" o) Z
1st Edition
4 z; H& h! F( h! f1 Q, H. gAuthors: Joo Chuan Tong Shoba Ranganathan
' W0 \( t- E9 W/ I- @7 KElectronic ISBN 9781908818416 Print ISBN 9781907568411
! u1 W2 v; g( V8 ]: }; T+ P$ `" b- }- n2 G! L
Description
! y1 E7 h- P% N& {) HComputational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.
( v6 B! @. c/ v. c7 e8 yComputer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.
/ V9 j6 p+ Z' T3 z1 X' ]1 w y6 [
4 [2 X; c* Q! u$ q8 v. ^- u# iTable of Contents
0 d( q& X% E5 p M+ gList of figures6 \+ X8 e* {. v7 V5 k7 D5 G
List of abbreviations
! w; ]' U5 y" D: A: q' t' rAbout the authors
3 R9 l A! Z, I" s" ~: E& X. U+ XPreface( K2 s9 n& J0 [7 Z' Z" X; a
Chapter 1: MHC and T cell responses2 ~7 U' e) Z/ R+ P- F; k* I' p
Abstract:1 K1 N# p. H% w3 I3 \
1.1 Genetic organization of the MHC
- v4 @9 o5 P7 b# w0 l( f, d, B1.2 MHC structure3 y& M- U2 V6 @5 G
1.3 MHC function% G; D; x& _" @6 }9 r, i0 W
1.4 Peptide binding
; j4 |: D. y5 B% xChapter 2: Immunoglobulins and B cell responses* t1 H, e' p4 j9 b8 m
Abstract:3 [0 ]; c# X. O! ~
2.1 Types of immunoglobulins
6 S+ N5 N, B3 P( t6 t# [6 @/ v2.2 Immunoglobulin structure
) O2 w1 R) }( a& A2.3 Immunoglobulin function
' s9 s D7 \ t) [; I% O2.4 Antigen binding
! i) @" @% H/ FChapter 3: Scientific publications and databases" ^1 J" [" v I' p& q5 I
Abstract:
% T8 a# f3 g- x) B# L3.1 Bibliographical information
9 f7 F- e7 Y9 {; l3.2 Searching the literature
B6 ?- h! N0 T3.3 General databases containing information on genes and proteins
, p0 A# {7 u5 h r, L3.4 Immunological databases1 `, |% I: \( {3 x& z' h
3.5 Small molecule databases- g* T. a' V5 d& x' `# b* k
Chapter 4: Database design, P' N! {9 G6 t! H2 D
Abstract:
: A1 `! ?. q) l3 P0 ?, Y5 w4.1 Fundamentals of database design" a* Y9 ?! f$ D2 i
4.2 ER diagram& s9 Z& c6 ^- T. w3 W; q
4.3 Normalization and normal forms' M2 L/ w8 M/ z0 r/ @( ~
Chapter 5: Computational T cell vaccine design m4 A: \) g, y& O0 e7 J. T
Abstract:
- e9 y' d* a' _4 b# [5.1 Sequence-based methods& x% v# {7 C: S' U3 t
5.2 Structure-based methods& e/ ?6 Z/ o" j5 a9 G
5.3 Broad-based T cell vaccine design
! m5 `" Y- A( n6 W6 |8 pChapter 6: Computational B cell vaccine design3 s [7 _) D$ S+ [# x% w& z
Abstract:) M, r2 q0 e. F$ P1 |7 Z
6.1 Sequence-based methods A* L/ J' L- d i: `8 v
6.2 Structure-based methods
3 I6 X, Y/ Q/ L: @& AChapter 7: Infectious disease informatics
' E+ C5 f" u. R$ h( |2 IAbstract:
) @; _/ ^# i$ y6 ]1 l, m9 s7.1 Infectious diseases in history! y0 C* N3 x. |( H8 E/ N& d
7.2 Microbial sequence analysis
, T3 J' b" a; {7.3 Detecting natural selection in molecular evolution7 ]. j( O8 M* L0 q
Chapter 8: Vaccine safety and quality assessments
' X2 u( `; e8 w. ~! {/ Z! G% A8 X7 lAbstract:% k: D% p p: c! ^# _: K
8.1 Assessment of ADME/Tox deficiencies
^ _9 `0 a1 j {4 @8.2 Assessment of allergenicity
" U! n4 ]( s+ \0 l4 RChapter 9: Vaccine adjuvant informatics2 W2 V+ A# d7 j4 ?2 Q6 }
Abstract:, p. s$ O9 Z) J: ^! W1 F
9.1 Virtual combinatorial library) j. ~: v$ T( s3 s
9.2 Chemical file formats
7 d$ P) S. S; `+ v3 r9.3 Considerations for virtual library design v' Q# e; i& a5 E
Index
& S) c0 D [! ~4 L* V1 Y. M) A" r ^; f& @2 A: w0 x. H" b
: Z% u6 U. j. x6 c: N9 p
" H5 d. o) r( O) v, n原文下载地址：5 {+ Z0 O2 W: \9 z5 B
8 ?% d: L6 f4 v& {+ j5 B. t' j0 [3 _0 _+ y/ N
|
本帖子中包含更多资源
您需要 登录 才可以下载或查看，没有帐号？立即注册
x
|
发表于 2016-8-16 12:18:44
QQ好友和群
QQ空间
腾讯微博
腾讯朋友
收藏
分享
支持
反对
发表于 2016-10-9 10:55:32
