Sci Rep：北大学者介绍人类乳头瘤病毒(HPV)在农村夫妇间的传染

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摘要 : 北京大学肿瘤医院的柯杨教授和蔡红教授及她们的研究团队追踪了874对25岁到65岁之间的中国农村地区的夫妇的生殖器HPV感染情况，在2009年到2013年期间进行了7次左右的每半年一次的检查。
北京大学肿瘤医院的柯杨教授和蔡红教授及她们的研究团队追踪了874对25岁到65岁之间的中国农村地区的夫妇的生殖器HPV感染情况，在2009年到2013年期间进行了7次左右的每半年一次的检查。他们发现年轻夫妇传染HPV的风险更高。中国农村地区的男性在向女性传播可引发宫颈癌的人类乳头瘤病毒(HPV)的风险比女性向男性传播的风险高四倍，论文本周发表在《Scientific Reports》上。

HPV感染可以导致女性患宫颈癌，也有引发口咽部的癌症和肛门生殖器癌症的风险。以往研究显示男性感染HPV会增加他们的伴侣宫颈癌的风险。但是在中国，HPV的传播特性在普通人群中很少被研究。

他们的分析也显示，男性传染致癌性HPV给女性的风险是每月每1000人中有12.13人会被传染，比女性传染给男性致癌性HPV的风险高四倍(每月每1000人中有2.37个会被传染)。研究者表示，这个数据和西方类似的研究有很大差异，西方的研究中女性传染致癌性HPV给男性的风险比男性传染给女性高。研究者认为中国农村男女之间性保守度的差异可能是这种中外差异的原因，同时呼吁防治HPV的措施应该包括性活跃的年轻男性。

原文链接：

Transmission of genital human papillomavirus infection in couples: a population-based cohort study in rural China

原文摘要：

HPV transmission dynamics have rarely been studied in the general population, especially in China. We followed the genital HPV infection status of both partners in 874 couples aged 25-65 years from rural China for up to 7 bi-annual visits during 2009-2013. The positive HPV concordance and transmission rate for partners in a couple were evaluated and relevant risk factors were assessed. The concordance of any, oncogenic, and non-oncogenic HPV was 15.52%, 16.18% and 10.41%, respectively. Male-to-female transmission rate was 7.11, 12.13 and 4.77/1000 person months for any, oncogenic and non-oncogenic HPV respectively. The female-to-male transmission rate was 5.56, 2.37, and 17.01/1000 person months for any, oncogenic and non-oncogenic HPV respectively. The risk of male-to-female transmission was significantly higher than that of female-to-male transmission for oncogenic types. However, for non-oncogenic types, the risk of male-to-female transmission was significantly lower than that of female-to-male transmission. Younger couples, persistent infection with HPV, higher numbers of sexual partners and higher frequency of sexual intercourse were positively associated with HPV transmission in couples. Our results indicate that men in rural China play a more important role than men in western populations as a source of cervical oncogenic HPV infection in women.