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标题: Adverse Effects of Vaccines-Evidence and Causality(2012) [打印本页]

作者: zhaox    时间: 2016-1-2 17:46
标题: Adverse Effects of Vaccines-Evidence and Causality(2012)
In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma. Adverse Effects of Vaccines will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors.
Copyright 2012 by the National Academy of Sciences. All rights reserved.


Sections
THE NATIONAL ACADEMIES
COMMITTEE TO REVIEW ADVERSE EFFECTS OF VACCINES
Reviewers
Preface
Acronyms
Summary
1. Introduction
2. Approach
3. Evaluating Biological Mechanisms of Adverse Events
4. Measles, Mumps, and Rubella Vaccine
5. Varicella Virus Vaccine
6. Influenza Vaccine
7. Hepatitis A Vaccine
8. Hepatitis B Vaccine
9. Human Papillomavirus Vaccine
10. Diphtheria Toxoid–, Tetanus Toxoid–, and Acellular Pertussis–Containing Vaccines
11. Meningococcal Vaccine
12. Injection-Related Adverse Events
13. Concluding Comments
APPENDIXES

作者: tonrol    时间: 2017-11-28 17:11
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