' l" k3 z( Y- R* c) U) N) h0 Y+ V" m1st Edition) s. {$ U# i: u; m+ {, ]( v
Authors: Joo Chuan Tong Shoba Ranganathan + e( n& g. m& W" j0 P! bElectronic ISBN 9781908818416 Print ISBN 9781907568411 # u2 ~5 a; }% D( a# d$ b' d- ^5 P) q: q1 r0 H8 w Description- \' t: D `6 G) v2 P
Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates. 3 r. a7 I0 O* Z6 n6 n& AComputer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics. M( @% u5 I, |. Q, I' U" s ^+ B! S, A3 O) s% q- g* u" ~9 I Table of Contents 5 [( M* @3 J) V9 ~8 ZList of figures% T, T% ]+ m) u8 w" P0 E
List of abbreviations $ e. W$ ]8 j- i) n2 aAbout the authors / ^. n7 r6 y9 [; T) P$ @Preface1 c0 ^" {5 @9 d: h2 }
Chapter 1: MHC and T cell responses9 q) m- k2 x, H7 A$ G
Abstract: / u1 L* `; O! V1.1 Genetic organization of the MHC " r8 H* l- l$ I2 _ Y8 ^1.2 MHC structure / M9 [; h% z8 y3 q4 A1.3 MHC function, n/ W. G( V6 S# h9 J; h, e
1.4 Peptide binding 0 w) g. G% l% B+ |& R- u6 k6 SChapter 2: Immunoglobulins and B cell responses7 l4 H. [2 \$ u7 ~. n# W! M" I
Abstract:' \4 N2 y: l2 F
2.1 Types of immunoglobulins" ~: ]* x r* i# G) {
2.2 Immunoglobulin structure " B F4 ^. }% U7 k4 x' \7 Y6 W2.3 Immunoglobulin function 2 H' V$ I. U3 j2.4 Antigen binding1 g' Y, o2 {+ E! T/ I5 L
Chapter 3: Scientific publications and databases : |* e7 s2 L( I! h& I* V. m% K2 w7 mAbstract: . N3 T! X8 A' F9 |9 A/ W3.1 Bibliographical information- t% B5 e. q0 ]1 U! K. t- q- F
3.2 Searching the literature+ e, |7 r6 o8 q6 A2 ^
3.3 General databases containing information on genes and proteins( H9 B% }6 ]' W, ?8 r2 V8 k
3.4 Immunological databases7 b4 ^0 K! ?' e- K
3.5 Small molecule databases ( I% k: s Q7 ?& tChapter 4: Database design3 F1 ^9 _# b+ k* P/ S
Abstract:. b3 b0 @: i: S( }8 Y
4.1 Fundamentals of database design # D, f/ P$ T! A4.2 ER diagram2 A) T1 B3 A) m5 [# k4 a! O
4.3 Normalization and normal forms $ H% Z5 J* d* B! n3 I! R2 c4 {& E! K. VChapter 5: Computational T cell vaccine design6 ~/ ?8 L% C9 I& F$ S
Abstract:% C" `3 i% L$ H
5.1 Sequence-based methods. ~$ U/ e. S8 q9 |) [) U
5.2 Structure-based methods1 @1 B; E' L# a- C7 @
5.3 Broad-based T cell vaccine design6 O" }# @) R j- D
Chapter 6: Computational B cell vaccine design 2 G* E& O8 c) [, KAbstract:; b( }1 k. l' u
6.1 Sequence-based methods7 [* D4 X8 m- A9 u* @9 q* j4 d4 @
6.2 Structure-based methods % [9 E% \5 }9 E& Q" Q+ xChapter 7: Infectious disease informatics4 d Z2 r. P6 C! x& ?8 J
Abstract:# z0 ~& P2 J; K; q+ H7 W; J
7.1 Infectious diseases in history1 | j1 v' S! y
7.2 Microbial sequence analysis 7 o# j" O) S) E, ? i* `7.3 Detecting natural selection in molecular evolution 8 R2 d$ L0 m% FChapter 8: Vaccine safety and quality assessments a) {* g. ?! b& u* O
Abstract:$ U% ]( } }% D8 r# e
8.1 Assessment of ADME/Tox deficiencies/ d! m/ V+ a: q* q l5 |- u
8.2 Assessment of allergenicity/ v9 U$ v E; a+ {) H9 l
Chapter 9: Vaccine adjuvant informatics& P9 Q3 d, {% m( q' r" ^) E
Abstract:& s% i5 }8 s3 G, S5 u7 e! d
9.1 Virtual combinatorial library8 c$ _' X6 @1 W6 M) c) g0 x
9.2 Chemical file formats* s" P/ t5 ~: T/ S7 L5 j) Y
9.3 Considerations for virtual library design * s! K0 ^) Z6 OIndex5 `1 [$ H+ X; l' M8 A) d. l
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