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本帖最后由 randomqd 于 2016-8-16 12:20 编辑 + K( c; Z4 _4 l m
) g+ s0 q2 N# z' z) D5 N1st Edition
) x1 R' ?1 g5 W! [Authors: Joo Chuan Tong Shoba Ranganathan
8 ]2 d3 q* e, Z6 nElectronic ISBN 9781908818416 Print ISBN 9781907568411
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Description, j# {" S. Z% R3 ~$ ?; v
Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.
4 t! P" l5 t) H/ y1 w: Q; u0 jComputer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.6 p( V* k) B& W/ H% h
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. |4 N& {' `: }; L% x" nTable of Contents
: ]+ R* a! p! S- r* U% g$ i LList of figures7 t+ j0 h) d8 V; Z" h$ }
List of abbreviations' \) P; b3 `' l! N7 _( S6 z
About the authors* M: J6 f! b( S3 X" F
Preface
" s" t" c: d+ w1 S* BChapter 1: MHC and T cell responses# Q/ y; C+ N, h
Abstract:
- T/ z; L# V7 v2 R( p1.1 Genetic organization of the MHC6 \: ]6 h8 B" {1 J- T# u% t
1.2 MHC structure+ w+ o) N1 b! w7 G8 g4 K! `' I
1.3 MHC function
. r. Q m" O( l$ f: |7 y1.4 Peptide binding
2 v. X% m6 z# X m3 j% JChapter 2: Immunoglobulins and B cell responses4 r/ K b0 {3 R7 J- E4 i1 @ N! g" P. y
Abstract:
8 P7 M& w2 [' `3 {2.1 Types of immunoglobulins5 t: J$ i' Q' N, {- l6 f
2.2 Immunoglobulin structure2 p6 G8 l" o# g! \# T$ m# s
2.3 Immunoglobulin function% O8 V* v2 c3 ]
2.4 Antigen binding
0 Y* k/ X1 O' z/ H* y5 VChapter 3: Scientific publications and databases9 H5 x5 {! o. M6 l: V8 r
Abstract:; @2 S; ~. W: n% }) S( _6 t
3.1 Bibliographical information
) A R: L2 }! B3 p3.2 Searching the literature+ ^$ x+ ^9 u- m2 f; ]& X7 _
3.3 General databases containing information on genes and proteins6 k7 }, ]7 F/ O* S7 ^
3.4 Immunological databases- Z; J* W f% Z7 E
3.5 Small molecule databases( e) }9 Y/ _0 S% U1 \. x: x
Chapter 4: Database design
+ {- t7 X$ T+ kAbstract:
+ s( g6 Y" Y! S( K4.1 Fundamentals of database design
" R( B# F/ F- L! C, V4.2 ER diagram
# o1 p! X( q! v1 N" M4.3 Normalization and normal forms) D8 p/ Z! s8 t9 H; k: ?; k' Y
Chapter 5: Computational T cell vaccine design
2 F) t) b g% [: b: P/ g8 iAbstract:
% M9 m( i* p- N: k; t, x5.1 Sequence-based methods( }0 ]0 }# i- k( ?5 K' T
5.2 Structure-based methods' c" _8 T& R4 a e
5.3 Broad-based T cell vaccine design
/ H& Y% ~* N" h8 bChapter 6: Computational B cell vaccine design: E6 n2 b* e5 M2 O d6 s; D o5 P
Abstract:( a+ H0 j; M; R) k- I. X4 M* B
6.1 Sequence-based methods2 U) ?! u( m2 _" H5 ~
6.2 Structure-based methods
3 O! |7 }% F* u( D8 d" l. HChapter 7: Infectious disease informatics: {5 }9 b* G# X i: n; @) Y
Abstract:
; g! w8 ]7 B1 [7.1 Infectious diseases in history
f5 }; B+ i( U5 I* c& ]; ?7.2 Microbial sequence analysis) L$ ?. p# G, [1 P
7.3 Detecting natural selection in molecular evolution
* I, Y: \) s: BChapter 8: Vaccine safety and quality assessments
" c9 i. {6 F$ Z; q* }Abstract:! g R) i D+ s: q* a- R L0 _7 K" L- E
8.1 Assessment of ADME/Tox deficiencies7 i$ p. e% m3 q* S6 H
8.2 Assessment of allergenicity
$ `% s% n) j9 q8 ^. |Chapter 9: Vaccine adjuvant informatics' ~, i& i! \8 Y) l4 g3 |" [
Abstract:3 C4 w; j3 Z& t$ p3 I- x
9.1 Virtual combinatorial library. c0 j4 F: L4 e& z" w) f8 d
9.2 Chemical file formats5 Y' c$ E" T4 d7 c" m
9.3 Considerations for virtual library design
4 q7 V4 u# h# r, @0 R: b4 YIndex
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发表于 2016-8-16 12:18:44
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发表于 2017-2-1 11:41:22
