[转移帖]研究称全球1/6癌症由可治疗的病毒感染引起

ms003

原帖由zzx219发表于 2012-5-10 21:21 ：

据英国广播公司5月9日报道，医学期刊《柳叶刀-传染病》近日发表研究文章称，全球1/6患癌者的癌症是由可治疗或可预防的细菌、病毒感染引起。

据报道，该文作者研究了27种癌症在184个国家的发病率，发现它们主要由四种感染引起，即人类乳头状瘤病毒(human papillomaviruses)、幽门螺旋杆菌(Helicobacter pylori)、乙型肝炎(hepatitis B)及丙型肝炎(hepatitis C)。据信这几种细菌和病毒导致了约190万子宫颈癌、肠癌和肝癌病例。大多此类疾病出现在发展中国家。


此项研究由总部设在法国的国际癌症研究机构主导，他们表示，需要进一步研究这些可避免的癌症病例，并称人们应意识到癌症也许是一种可传染的疾病。研究称，在发展中国家因感染引起的癌症发病率约是发达国家的三倍，50岁以下的患者占1/3。

该文章作者凯瑟琳·马特尔(Catherine de Martel)和马丁·普拉默(Martyn Plummer)称，细菌、病毒和寄生虫是最大的致癌因素，尽管这些因素是可以避免的。文中写道，“利用现有医疗框架中的服务如疫苗、安全注射、抗菌措施等预防感染，会对未来减轻癌症给全球带来的巨大负担产生积极影响。”此外，专家称胃癌可以通过服用抗生素防止幽门螺旋菌感染内脏来避免。

ms003

503814发表于 2012-5-11 12:18：

楼主弄错了吧，是《柳叶刀-肿瘤》
The Lancet Oncology, Early Online Publication, 9 May 2012
doi:10.1016/S1470-2045(12)70137-7

Global burden of cancers attributable to infections in 2008: a review and synthetic analysis

Background
Infections with certain viruses, bacteria, and parasites have been identified as strong risk factors for specific cancers. An update of their respective contribution to the global burden of cancer is warranted.
Methods
We considered infectious agents classified as carcinogenic to humans by the International Agency for Research on Cancer. We calculated their population attributable fraction worldwide and in eight geographical regions, using statistics on estimated cancer incidence in 2008. When associations were very strong, calculations were based on the prevalence of infection in cancer cases rather than in the general population. Estimates of infection prevalence and relative risk were extracted from published data.
Findings
Of the 12·7 million new cancer cases that occurred in 2008, the population attributable fraction (PAF) for infectious agents was 16·1%, meaning that around 2 million new cancer cases were attributable to infections. This fraction was higher in less developed countries (22·9%) than in more developed countries (7·4%), and varied from 3·3% in Australia and New Zealand to 32·7% in sub-Saharan Africa. Helicobacter pylori, hepatitis B and C viruses, and human papillomaviruses were responsible for 1·9 million cases, mainly gastric, liver, and cervix uteri cancers. In women, cervix uteri cancer accounted for about half of the infection-related burden of cancer; in men, liver and gastric cancers accounted for more than 80%. Around 30% of infection-attributable cases occur in people younger than 50 years.
Interpretation
Around 2 million cancer cases each year are caused by infectious agents. Application of existing public health methods for infection prevention, such as vaccination, safer injection practice, or antimicrobial treatments, could have a substantial effect on the future burden of cancer worldwide.
Funding
Fondation Innovations en Infectiologie (FINOVI) and the Bill & Melinda Gates Foundation (BMGF).