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发表于 2015-10-22 22:48:01
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这是2006年nature做的专访,做流感病毒的不能不知道这个人
Nature Medicine - 12, 489 (2006)
Profile: Yoshihiro Kawaoka
If people make comments, I don't say a word. I don't care what other people think.
Even in a constant state of jetlag, Yoshihiro Kawaoka is a fiercely productive flu researcher. Wonder what he could accomplish with a little bit of sleep?
If Yoshihiro Kawaoka owned a country, its citizens would be well protected from a bird flu pandemic.
Confronted with a pandemic, Kawaoka says he would close his country's borders and release a vaccine based on the live, but weakened, bird flu virus. Some people might fall ill from the vaccine strain, but far greater numbers would benefit. "The immune response provided by live virus, that is going to be the one that really protects humans," Kawaoka says.
He is only half-serious. Kawaoka knows that closing borders is impractical and would at best only stall the pandemic. But when it comes to a vaccine, he knows of what he speaks.
Kawaoka engineered a method to generate entire viruses from genetic sequences, a technology that's now used to make flu vaccines. He has published paper after high-profile paper describing what makes certain flu viruses lethal and how they acquire resistance to available drugs. Most recently, he suggested that the H5N1 virus prefers to bind receptors far down in the lungs, making it more difficult for the virus to jump between people (Nature 440, 435–436; 2006).
Since 1999, Kawaoka has juggled dual appointments at the University of Tokyo and the University of Wisconsin in Madison. Full-sized labs at each institution churn out top-notch publications, 27 in 2005 alone.
"I'm glad that I work with him and don't have to compete with him," says Heinz Feldmann, chief of special pathogen programs at Canada's National Microbiology Laboratory, and Kawaoka's collaborator on Ebola virus research.
Kawaoka became interested in Ebola after reading The Hot Zone, the only English novel he says he has ever read. But soon after he began working in the field, "Yoshi really came on the scene with a bang," recalls Tom Geisbert, chair of viral pathology at the US Army Medical Research Institute of Infectious Diseases in Fort Detrick, Maryland.
How Kawaoka has the energy to do so much is a mystery. He doesn't eat much, sleeps even less and is perpetually jetlagged. To keep up his dual appointment, he often travels to Tokyo, sometimes for just a day.
Even as a postdoc at St. Jude Children's Research Hospital in Memphis, Tennessee, Kawaoka was in the lab when the cleaning lady arrived in the early evening, would go home to sleep at some point and be back again, ready to start the next day, before she left. "We're all amazed at how he can physically manage to function so well in two different time zones," says Krisna Wells, who has worked with Kawaoka since 1987 |
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