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本帖最后由 randomqd 于 2016-8-16 12:20 编辑
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1st Edition
) {9 ]1 R( b* u6 WAuthors: Joo Chuan Tong Shoba Ranganathan4 U& n6 U! r( l' O r: h/ a
Electronic ISBN 9781908818416 Print ISBN 97819075684116 p& ^0 ~, R% i5 D2 s9 n3 o S
! J+ N* X. }' bDescription
. f6 l: b; s T. I$ W/ G& D. W) X- }Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.
! u7 w# {! q* l, LComputer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.
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Table of Contents. @4 ]7 R% R. \0 l6 g* s- H: H" u, N
List of figures7 E4 m6 N1 ~! k3 @6 c. R7 O9 r' f
List of abbreviations/ C2 W$ ?) l( P9 W! k8 R* _
About the authors
- S9 [$ z2 m4 MPreface
' z- q7 r/ U9 _3 [) q# R9 `# VChapter 1: MHC and T cell responses7 r* g |: N5 n
Abstract:
0 n f5 i4 |! @) ?+ Z9 U& F1.1 Genetic organization of the MHC/ Y* x$ F( W4 c3 t* I7 Q
1.2 MHC structure
4 {9 y. `# I0 K. n$ x8 G& [2 F1.3 MHC function7 h3 O2 f: @2 q9 E% t: q5 n' C
1.4 Peptide binding! H1 z! w. U- N/ Y# {
Chapter 2: Immunoglobulins and B cell responses# M3 {6 @) U; f1 T8 {2 k. y
Abstract:% T- t7 e* l! z3 v9 N
2.1 Types of immunoglobulins* t- u3 u0 L V; B7 i$ d9 P
2.2 Immunoglobulin structure
$ n0 K& T: R% P, s2 H2.3 Immunoglobulin function
9 p" R# C8 h2 D2.4 Antigen binding
; N# q7 Q; O$ [& H6 YChapter 3: Scientific publications and databases
0 q" i) l1 l8 o* S, Z) IAbstract:
W+ w5 | _3 c5 A( E% V7 d# |3.1 Bibliographical information3 u# `* `2 k3 ?: H( _/ y. f
3.2 Searching the literature& |3 H) T7 y2 b+ N) d
3.3 General databases containing information on genes and proteins- w ^$ S Q- c/ E
3.4 Immunological databases
& n ]4 T8 V6 I5 Y0 M/ p3.5 Small molecule databases& {9 f: u. e1 \& T) V
Chapter 4: Database design" p! ]7 o: ^ n" _
Abstract:" `& y7 [! e/ q$ D8 @
4.1 Fundamentals of database design: T' v" t. t: ]1 u( H9 b) t; S
4.2 ER diagram
: M" D$ P' I8 T2 h) G& a2 r4.3 Normalization and normal forms6 c: F* [0 P1 B4 q. p
Chapter 5: Computational T cell vaccine design# n8 G1 T8 i+ N3 j
Abstract:* A$ e( Q$ i+ |0 n. C2 D7 \
5.1 Sequence-based methods1 U- k! E% K5 \! y; J6 J% B! s
5.2 Structure-based methods
+ A; f: l1 a2 F/ \% z; b- O9 b( _ D4 ^3 z5.3 Broad-based T cell vaccine design2 M- u, V: v2 Z
Chapter 6: Computational B cell vaccine design0 ~! Q/ v, N" {9 G2 L4 h/ p' T
Abstract:
6 u2 n$ m: N& z+ L; C! T" V0 k$ g6.1 Sequence-based methods! G4 e/ w2 d. ^# I& w
6.2 Structure-based methods) T% o! Q" R* H( v [% {
Chapter 7: Infectious disease informatics
' Z3 @9 s, E0 a$ I9 ^3 kAbstract:
R' ]( E0 ?! z8 Q) U: Q7.1 Infectious diseases in history
% X- _. C; Q2 ~% U6 }7.2 Microbial sequence analysis* ]8 Q9 b! q' w6 Z% Y* v
7.3 Detecting natural selection in molecular evolution, @# r* y7 P8 b
Chapter 8: Vaccine safety and quality assessments7 u7 t: A: N0 @" P, b$ L
Abstract:
- s m2 l0 X2 u8 P( o0 z+ ^8.1 Assessment of ADME/Tox deficiencies1 N: S( }7 t: c) Y) X3 |. ~8 |5 h& M4 I l
8.2 Assessment of allergenicity
/ n- l2 f: ~: b, i+ S* AChapter 9: Vaccine adjuvant informatics
U0 Z; a6 W1 A6 }* ]' ^+ f. rAbstract:+ ~. ]! V |0 S N
9.1 Virtual combinatorial library
; q* n2 n4 o) G; O' Y7 W) }9.2 Chemical file formats3 G+ Z* X( E8 G# N; d
9.3 Considerations for virtual library design
& k' Y3 f. s: c( _/ b; Z" k& K; K5 xIndex
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