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本帖最后由 randomqd 于 2016-8-16 12:20 编辑
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{5 c, ~ o! H- s b1st Edition
2 o, @+ F0 M- MAuthors: Joo Chuan Tong Shoba Ranganathan# @; ]4 }; N, Z9 l/ C/ [8 q) I0 D
Electronic ISBN 9781908818416 Print ISBN 9781907568411
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Description
* i4 v& ?* H5 p" n/ lComputational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.8 x: F# }) N5 l
Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.
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/ } s Q6 L% Z gTable of Contents
4 |: ]& z. a! z/ }5 h; Z& u$ K' MList of figures
G* S* I" I+ A& j8 ^List of abbreviations
7 n0 T* X, K+ K3 p6 T) fAbout the authors. b2 N0 @: d7 X+ E' U* w1 \' j: K
Preface
% V; A! {% p3 x) A( nChapter 1: MHC and T cell responses" V6 _6 t; B" S9 Q2 H
Abstract:
, |. `0 n$ R6 W4 z1 Z1.1 Genetic organization of the MHC
! n5 Y$ X* L( k" q! E1.2 MHC structure
+ e: L" [ o3 o+ Q6 u1.3 MHC function0 N; |8 d9 t' ~6 O
1.4 Peptide binding7 H8 G8 r" d! C
Chapter 2: Immunoglobulins and B cell responses. P4 x. @ v2 I9 c+ v g
Abstract:; a- n$ N9 ]$ J* C3 ~. r
2.1 Types of immunoglobulins
F8 I8 B: R9 h2.2 Immunoglobulin structure/ j( ?! c' K/ u9 l$ @1 H8 P
2.3 Immunoglobulin function3 _3 l7 G9 [$ Y3 r
2.4 Antigen binding! h# x3 N+ m$ H; q; [/ {5 m& q
Chapter 3: Scientific publications and databases
" i8 _; V! {9 \- bAbstract:8 I/ `# e9 E9 y* P8 A
3.1 Bibliographical information
& f6 h6 S/ h/ u5 S; U! j3.2 Searching the literature1 }7 b6 S& }5 a# q4 G0 K
3.3 General databases containing information on genes and proteins
& M/ h8 i" P8 k$ w3.4 Immunological databases
1 s2 `; o$ j# O8 r4 c/ n- `4 ?0 C3.5 Small molecule databases
& y, g0 Y! |! Z, G1 v1 fChapter 4: Database design
" n' O' n- ?+ ]& P2 G0 BAbstract:
1 @5 e/ d+ G+ F& W4.1 Fundamentals of database design
) S0 T! _9 c& L1 x4.2 ER diagram
9 a. q6 `( j l, b' r, d- f6 N- ^4.3 Normalization and normal forms
$ C( t: B# o+ B _+ u4 a) LChapter 5: Computational T cell vaccine design6 ^1 a. g* k% W1 h& v4 q
Abstract:
6 `- T" |0 `4 h" @* U! C- G7 l5.1 Sequence-based methods$ v' b: D1 ?9 r. K. i- m* A
5.2 Structure-based methods
8 e! H, I& v6 e9 k- z5.3 Broad-based T cell vaccine design
9 m; A- H2 k% w" @: yChapter 6: Computational B cell vaccine design
4 q4 f& g/ ?& K( L; A! |$ k* Q9 C/ M0 sAbstract:
: p7 w2 Z: f- {) G! j# H6.1 Sequence-based methods1 ~/ C; d: v, {6 }3 r; `% W
6.2 Structure-based methods
7 I# d- @6 p& l) |: KChapter 7: Infectious disease informatics
; Z7 |' b: g2 P+ @7 p& a0 w4 AAbstract:% P8 m7 `, W" H; b/ ~1 Z' C
7.1 Infectious diseases in history
" e A' p- c. U( q3 [9 ]# \7.2 Microbial sequence analysis9 J( f' ~8 f6 C# g
7.3 Detecting natural selection in molecular evolution- f0 }( j3 a2 a
Chapter 8: Vaccine safety and quality assessments' q: l- k( U% ]6 s9 ?
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8.1 Assessment of ADME/Tox deficiencies
- u. a6 ?* ?% w/ H3 r* o8.2 Assessment of allergenicity
% |3 r U! N5 H1 f: _7 xChapter 9: Vaccine adjuvant informatics4 R! ^( b- K" u3 a& T! \
Abstract:
. O3 k% q* m, E2 D4 K9.1 Virtual combinatorial library
, h( F* }' f- \: i- e# X$ Y5 W2 m9.2 Chemical file formats
Y' W6 {- Y! D, _9.3 Considerations for virtual library design6 M' K8 X4 u8 |0 ?' w
Index
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