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本帖最后由 randomqd 于 2016-8-16 12:20 编辑 ' K/ {/ t8 A$ p, H
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1st Edition
& Q f8 J; J; A6 ^Authors: Joo Chuan Tong Shoba Ranganathan" c8 Y& \& c0 P- n- O
Electronic ISBN 9781908818416 Print ISBN 97819075684110 @4 I1 ?( y, W$ i
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Description
$ k! U; }& c. T0 O: B+ {) QComputational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.
+ ^! o/ C, t9 H, a' sComputer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.2 r; _( o$ @* s7 R) E
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4 o; W- G0 H, B9 L. ZTable of Contents
0 V/ K7 f4 e3 u+ _. f$ k( EList of figures5 k9 D* ^. o5 R+ P5 A( ?3 o
List of abbreviations2 S$ f; c& `2 I6 u# ^# c- H/ Y N
About the authors' r, ]$ d6 k# ~3 y8 \' {+ U& q$ ?
Preface3 X3 n, v' o. m3 n& G; Z
Chapter 1: MHC and T cell responses" k7 p& n e" g3 H
Abstract:7 D5 ?1 v; m8 D- t9 O1 I2 D# T8 L
1.1 Genetic organization of the MHC
, t* f+ g8 p" K7 @- |; p1.2 MHC structure
6 q# R6 A7 d+ e: s7 i# D1.3 MHC function
% D. R7 S- T6 o/ v! o5 X* y) y7 t1.4 Peptide binding. B0 {7 [: C8 l2 ~/ V
Chapter 2: Immunoglobulins and B cell responses6 f& e" |$ S+ ^/ r6 x9 `# l
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2.1 Types of immunoglobulins6 ]. U7 O- s$ N5 r
2.2 Immunoglobulin structure
' Z# [8 P: S9 J3 G! M7 X2.3 Immunoglobulin function; L# X4 V" _: I6 [; V- k
2.4 Antigen binding
$ X! f& G3 d6 s! hChapter 3: Scientific publications and databases# B0 y1 K. u9 W% I3 t
Abstract:
: H! Z1 K! t/ p7 G: ]5 B0 r7 W$ X3.1 Bibliographical information
' L" d0 m9 V% K. L" y3.2 Searching the literature' O% d' p& W# m9 p t" O
3.3 General databases containing information on genes and proteins
. V1 y' T5 Y7 l! x3.4 Immunological databases
4 t8 U# v8 w$ t: s0 @3.5 Small molecule databases
2 e( R" ^* A& B! X* O! `; C1 GChapter 4: Database design
4 p. A! C* G6 T: S, Y) PAbstract:
8 i7 L5 N6 p1 S2 ]/ u5 w1 ?% K3 g/ U4.1 Fundamentals of database design
3 x9 t# s% L* z4.2 ER diagram
) P; `( r# @+ o7 A4 B' A# Y4.3 Normalization and normal forms
$ _4 I# I1 F' aChapter 5: Computational T cell vaccine design
5 n$ y$ v+ @ C( YAbstract:: ?! C! K. ]5 C! U+ h0 L
5.1 Sequence-based methods6 K# v1 P3 ^$ u# F4 c+ N1 p) P* d
5.2 Structure-based methods# n4 L0 W9 [$ O; F. O) f
5.3 Broad-based T cell vaccine design3 e; f4 w- _1 n4 G6 d0 t
Chapter 6: Computational B cell vaccine design2 V, K/ J# O% Q) ~9 g
Abstract:9 @( r, } q' i& G! x% S
6.1 Sequence-based methods5 w1 J L2 z% I1 k b. V& k+ Q
6.2 Structure-based methods
* d( \, i3 J) r7 ?! OChapter 7: Infectious disease informatics
+ B6 M; A+ I; t1 kAbstract:5 |4 S" |0 @; R
7.1 Infectious diseases in history1 c: {" S# k1 @0 @5 N) @4 H
7.2 Microbial sequence analysis7 p3 U7 N' L( ]/ _
7.3 Detecting natural selection in molecular evolution% t9 |3 i$ d( W4 ~. x/ ~
Chapter 8: Vaccine safety and quality assessments
8 z( _( i2 A Q+ Y4 tAbstract:& p! a* E: ~& [' l! j6 Z
8.1 Assessment of ADME/Tox deficiencies
r2 \% `" D$ b, W- D. T8.2 Assessment of allergenicity1 O: r" {4 x% Z: C7 _. P: e
Chapter 9: Vaccine adjuvant informatics+ G6 S" q( h/ U+ X4 V( I
Abstract:2 X+ h# I/ A/ m) ?/ \) H3 q% z
9.1 Virtual combinatorial library
' E8 }, ^# z' k" Y3 L# ?9.2 Chemical file formats
9 }9 L( F; @) T9.3 Considerations for virtual library design2 ]* V5 `- e; a5 c9 o2 x' t' u
Index# i0 y) C% C8 z' V( n! g" T2 p0 ~( L
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5 {9 j# K# l& t2 t( \" A原文下载地址：
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发表于 2016-8-16 12:18:44
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发表于 2017-2-1 11:41:22
