计算机辅助疫苗设计Computer-Aided Vaccine Design

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# [$ Z3 `" \, j: R' W1st Edition
Authors:  Joo Chuan Tong Shoba Ranganathan
6 h0 `3 i0 P4 V! H1 d0 kElectronic ISBN 9781908818416  Print ISBN 9781907568411
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Description
7 K6 \4 V% F7 j3 vComputational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.
# s- p! M! ^( r0 V  q- N$ E7 C! G6 EComputer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.

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5 ]5 y8 @/ x5 t$ @7 DTable of Contents
0 ]. s6 a+ B) X2 ]  [. o! ], MList of figures
List of abbreviations
/ B1 _$ q/ P4 _6 P8 \8 DAbout the authors
Preface
Chapter 1: MHC and T cell responses
Abstract:
4 _: ?$ T  ]  V* x/ W1.1 Genetic organization of the MHC
1.2 MHC structure
1.3 MHC function
. f0 k1 H' L# q0 `3 `1.4 Peptide binding
Chapter 2: Immunoglobulins and B cell responses
, D7 Q& C% N. n1 J1 YAbstract:
$ _; W7 d( [2 _; S- A- i2.1 Types of immunoglobulins
# `  T1 ?4 m  b4 i- H2.2 Immunoglobulin structure
2.3 Immunoglobulin function
2.4 Antigen binding
Chapter 3: Scientific publications and databases
! Q% p; j5 v# g  a9 L$ D6 `0 V8 bAbstract:
' V! _" a5 U7 g3.1 Bibliographical information
6 @( f" o! m: Q1 A) L9 |8 U3.2 Searching the literature
3.3 General databases containing information on genes and proteins
3.4 Immunological databases
3.5 Small molecule databases
6 q9 t: @7 b7 H8 D0 Q* h* N; v5 dChapter 4: Database design
$ _/ b; u5 w, y! b" J. H% TAbstract:
4.1 Fundamentals of database design
4.2 ER diagram
4.3 Normalization and normal forms
Chapter 5: Computational T cell vaccine design
/ p$ x, v6 P1 PAbstract:
; ]% [. {  H0 e" n5 G, x: l5.1 Sequence-based methods
7 i: X: K; C! ?# T9 ]; k5.2 Structure-based methods
" R/ F+ h7 |/ |, ^* F+ M0 X5.3 Broad-based T cell vaccine design
Chapter 6: Computational B cell vaccine design
5 y- Z" V+ l9 @$ b) w# NAbstract:
6.1 Sequence-based methods
, s+ y9 a, G* l% J. [' Z) ?6.2 Structure-based methods
Chapter 7: Infectious disease informatics
Abstract:
7.1 Infectious diseases in history
7.2 Microbial sequence analysis
% X: s/ p# b  y7.3 Detecting natural selection in molecular evolution
$ N! R4 A6 k# P! n8 H' jChapter 8: Vaccine safety and quality assessments
$ f( u( r- B$ M( O& {Abstract:
. @# t& A& [3 m7 y8.1 Assessment of ADME/Tox deficiencies
8.2 Assessment of allergenicity
Chapter 9: Vaccine adjuvant informatics
) G. T3 [% ~  i2 H4 bAbstract:
  Z6 }5 y$ S/ y9 x4 }. R! [9.1 Virtual combinatorial library
9.2 Chemical file formats
, A: {6 G+ Q+ }) U" c9.3 Considerations for virtual library design
9 U4 Q8 C; ?+ Q" m9 FIndex
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