中山大学：登革热是由登革病毒隐性感染的急性传染病！

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据相关消息显示，就在昨日，中山大学登革热研究取得重要发现：隐性感染是登革热暴发流行的重要推手。3月31日，该研究论文发表于国际知名专业期刊《PLoS Neglected Tropical Diseases》（《被忽视的热带疾病》）

登革热是由登革病毒感染引起的一种急性传染病，被认为是最重要的虫媒性传染病。在过去15年间，登革热发病率上升了70%，主要遍及热带、亚热带100多个国家和地区。每年约有5000万到1亿人口感染登革病毒。
    目前，尚无有效的登革热疫苗和特异性治疗药物可以应用。登革热是广东常见、多发的急性传染病之一，也是重点防控的传染病。2013年—2014年连续两年出现登革热大暴发，尤以2014年严重，2014年广东省发病数达45171例。
    中山市疾病预防控制中心汪涛主任医师领衔的团队和中山大学公共卫生学院陆家海教授团队联合攻关，开展此项研究。研究结果发现，登革热流行中隐性感染和显性感染的比例为2.2:1。登革热暴发疫情中，人们往往重点关注发病人群（即显性感染），而忽视隐性感染人群，这一研究结果首次阐释了登革热隐性感染者作为传染源对于疾病蔓延的重要影响，对制定登革热防控策略具有重要的科学价值。

     在这个流行病高发的季节，一定要注意各方面的预防措施。

[size=0.8465em]PLoS Negl Trop Dis. 2015 Mar 31;9(3):e0003677. doi: 10.1371/journal.pntd.0003677. eCollection 2015.
Evaluation of inapparent dengue infections during an outbreak in southern china.[size=0.923em]Wang T[size=0.8461em]1, Wang M[size=0.8461em]2, Shu B[size=0.8461em]2, Chen XQ[size=0.8461em]2, Luo L[size=0.8461em]2, Wang JY[size=0.8461em]2, Cen YZ[size=0.8461em]2, Anderson BD[size=0.8461em]3, Merrill MM[size=0.8461em]4, Merrill HR[size=0.8461em]5, Lu JH[size=0.8461em]6.
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Abstract

Few studies evaluating inapparent dengue virus (DENV) infections have been conducted in China. In 2013, a large outbreak of DENV occurred in the city of Zhongshan, located in Southern China, which provided an opportunity to assess the clinical spectrum of disease. During the outbreak, an investigation of 887 index case contacts was conducted to evaluate inapparent and symptomatic DENV infections. Post-outbreak, an additional 815 subjects from 4 towns with, and 350 subjects from 2 towns without reported autochthonous DENV transmission, as determined by clinical diagnosis, were evaluated for serological evidence of dengue IgG antibodies. Between July and November 2013, there were 19 imported and 809 autochthonousdengue cases reported in Zhongshan. Of 887 case contacts enrolled during the outbreak, 13 (1.5%) exhibited symptomatic DENV infection, while 28 (3.2%) were inapparent. The overall I:S ratio was 2.2:1 (95% CI: 1.1-4.2:1). Post-outbreak serological data showed that the proportion of DENV IgG antibody detection from the 4 towns with and the 2 towns without reported DENV transmission was 2.7% (95% CI: 1.6%-3.8%) and 0.6% (95% CI: 0-1.4%), respectively. The I:S ratio in the 3 towns where clinical dengue cases were predominately typed as DENV-1 was 11.0:1 (95% CI: 3.7-∞:1). The ratio in the town where DENV-3 was predominately typed was 1.0:1 (95% CI: 0.5-∞:1). In this cross-sectional study, data suggests a high I:S ratio during a documented outbreak in Zhongshan, Southern China. These results have important implications for dengue control, implying that inapparent cases might influence DENV transmission more than previously thought.