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本帖最后由 randomqd 于 2016-8-16 12:20 编辑
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" \3 E T8 r: O- G+ a( q1st Edition
$ {6 u# n6 T) l4 k4 TAuthors: Joo Chuan Tong Shoba Ranganathan4 \! z! C3 y3 ?
Electronic ISBN 9781908818416 Print ISBN 9781907568411
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! j0 @# y7 r. V+ c7 }Description1 M, e9 U' @# c! Z+ h2 K
Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.% y2 A* ~3 C1 Z% q9 ?7 U- Y
Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.
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Table of Contents
4 Z* ~" f2 j. j; x( ^4 T( SList of figures
1 ~5 B+ V W) z- ~List of abbreviations* W& g% E# D7 b, t# S/ ~: a7 A2 d
About the authors# w: w- E4 u5 | @- s9 ]: C* T5 U% p
Preface
8 G( g2 H+ n( F$ p! [ }Chapter 1: MHC and T cell responses
/ F% B# k3 o/ UAbstract:$ C7 x1 U' _+ K3 F& O# F4 E8 z
1.1 Genetic organization of the MHC& M- s; p7 |6 [. z6 E m$ w
1.2 MHC structure3 f7 l9 B8 ]/ _7 G
1.3 MHC function: W# F; ?# \; b- P/ k9 I$ \- m
1.4 Peptide binding. K# E- q$ x: Q5 k: ?' |& g
Chapter 2: Immunoglobulins and B cell responses
1 F' j0 Y f; O, l( fAbstract:
. u( q& q) E" { U2.1 Types of immunoglobulins
7 ^8 \1 A9 P% ]" y& H) _) e2.2 Immunoglobulin structure: u* t0 J9 @9 r" `
2.3 Immunoglobulin function
* K" t% K* W: {+ J. T3 I# c2.4 Antigen binding( n: Z9 T! z( R
Chapter 3: Scientific publications and databases0 B! y) z9 j1 _- ] d
Abstract:
' K% b; }+ Z- `0 y3 j3.1 Bibliographical information0 O" `0 r& x1 h2 V
3.2 Searching the literature
1 `. e, Z, F! i2 j! E; w' A1 e3.3 General databases containing information on genes and proteins, ~! r* a- K5 W' \& v0 U, Q1 `$ g
3.4 Immunological databases
0 O) m6 Z2 f3 H3.5 Small molecule databases8 t! {) @$ E. x: s( @$ t
Chapter 4: Database design
c9 E- T' O! zAbstract:
1 f H/ u5 M# n' x4.1 Fundamentals of database design! E! y! W4 n* f
4.2 ER diagram
' g& l5 ]6 }4 v4.3 Normalization and normal forms/ [# D: j8 P# ^+ X; ]
Chapter 5: Computational T cell vaccine design
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5.1 Sequence-based methods% g* }5 S; I+ q( r! Z2 {) @
5.2 Structure-based methods# |+ S5 m2 X l4 }7 |) W% Q. q
5.3 Broad-based T cell vaccine design' f1 A3 a# E! Z# X: b0 _* O
Chapter 6: Computational B cell vaccine design
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4 i8 T6 R2 B9 S! c: _6.1 Sequence-based methods
1 \: G- {& p. I& d6.2 Structure-based methods
1 y! ?7 g8 n8 s) ]* A# yChapter 7: Infectious disease informatics7 J1 X# p1 o- }' W& h
Abstract:
9 p+ i ]; K7 M% H) J- c7 m0 r2 ~7.1 Infectious diseases in history
2 ]; } u. f3 l7.2 Microbial sequence analysis
- j& ~$ @+ A" h# S7.3 Detecting natural selection in molecular evolution5 {8 @4 ]& R: U6 D `
Chapter 8: Vaccine safety and quality assessments3 n2 c Q2 [& y7 i6 m: Z
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8.1 Assessment of ADME/Tox deficiencies9 t. R6 n t0 e0 Y' N2 W
8.2 Assessment of allergenicity, D" _6 c1 ~8 u1 F7 f* L
Chapter 9: Vaccine adjuvant informatics
- `' w( \2 q3 T8 o5 Y4 vAbstract:
+ s* D n. }8 ^; V7 J+ e, u$ c9 e9.1 Virtual combinatorial library% ^1 w& z* L9 d7 R( k1 x) a2 M* C
9.2 Chemical file formats
- \5 |# @% @$ J. n( s' `) p9.3 Considerations for virtual library design
- i8 A$ o3 Y+ t) g1 U) eIndex
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