病毒学公开课系列之四：Structure of viruses，附 PPT下载地址

hantavirus

) Q* Q  R2 M: A. b
演讲题目：Structure of viruses
0 Z8 C% T$ c' ~9 ?: q5 P& f演讲者：Prof. Vincent Racaniello, Ph.D.
+ [3 K+ E- s% ]# }, g
演讲者单位：哥伦比亚大学
内容简介：主要讲解了下病毒的结构学相关知识，图文并茂，适合中级进阶者学习专业知识和练习英文之用。

" U5 p" I0 v; h" s附完整视频：
总时长66分钟，1080高清，总计约280M，强烈建议在wifi环境下打开观看，土豪请随便！
2 C* O6 V9 Y# Y& U

  _1 F$ n  q% |   
9 O, `' e" X/ K, E4 f( U
/ X/ P# w' ^" X7 W" o; {精彩内容展示：

- f" d# U' R9 |
5 ]0 P+ X/ j5 o2 \. \! g首先讲解了病毒结构蛋白的主要功能，主要有两个功能，即Protection of the genome和Delivery of the genome。


6 E9 O8 \% h) N/ B
随后是阐述了关于病毒结构的几个重要概念，即：
& c- o2 O- N) m' _) k4 Z# _4 Y

The tools of viral structural biology
4 X  d* t4 P+ n/ t• Electron microscopy
+ O' b& m  M' e4 {- B" T• X-ray crystallography
• Cryo-electron microscopy (cryoEM) & cryo-electron tomography
• Nuclear magnetic resonance spectroscopy (NMR)

9 o( E/ s. K) L 展示了几种常见病毒的模拟结构彩图，如Poliovirus，Zika Virus等。

+ L6 Z3 |, y3 n1 P; m4 S4 v/ D% B
2 M( u2 L) b: q* T% J  k
; N7 C$ c: C' l" Q6 Q7 {
# `7 N+ Q. ^$ t% K# K1 ]  
9 Q+ }0 n% o& |3 x: l2 F+ uBuilding virus particles: Symmetry is key
7 n. t1 x$ A- q* J  A. YWatson and Crick did more than discover DNA structure
Their seminal contribution to virology:
# c* U8 ]5 u$ a) h5 I$ J9 j- Identical protein subunits are distributed with helical symmetry for rod-shaped viruses
# V  I9 `/ a4 L- e- Platonic polyhedra symmetry for round viruses
: b  C9 U) v; ^" J# J+ u7 H7 V
: w, J/ B$ J% w( B+ g5 t% g; EThe symmetry rules are elegant in their simplicity，They provide rules for “self-assembly”
$ C5 h! j* ?1 q- t" ]5 j0 lRule 1: Each subunit has ‘identical’ bonding contacts with its neighbors
- Repeated interaction of chemically complementary surfaces at the subunit
+ |( o3 l) E) {4 _; X+ _2 ainterfaces naturally leads to a symmetric arrangement
Rule 2: These bonding contacts are usually non-covalent
2 u3 N3 h' h" r0 \3 V- Reversible; error-free assembly
. K2 H1 j4 l. p! H7 K' l
; I$ y; q) H! B( S+ L% u
: j* k4 B8 x+ pHow can you make a round capsid from proteins with irregular shapes?
• Clue 1: All round capsids have precise numbers of proteins; multiples
8 J! P/ L6 a! q6 F  `$ ~of 60 are common (60, 180, 240, 960)
• Clue 2: Spherical viruses come in many sizes, but capsid proteins are
20-60 kDa average
$ G  Z7 |- {( {+ i9 b
$ J' v4 e: w% b/ m  N6 x
6 {3 X2 @4 a  L
8 w, D& `* F  ?: b0 _
附 Vincent R. Racaniello教授简介
3 h% N4 A  O+ E  g. W       Prof.Vincent R. Racaniello (born January 2, 1953 in Paterson, New Jersey) is a Higgins Professor in the Department of Microbiology and Immunology at Columbia University’s College of Physicians and Surgeons. He is one of four virologists who has recently authored Principles of Virology, a textbook used by many teaching virology to undergraduate, medical and graduate students.
( m2 r8 v' C  ~       As an esteemed member of the scientific community, Racaniello has received several awards including Irma T. Hirschl, Searle Scholars, Eli Lilly and NIH Merit. He has also been a Harvey Society Lecturer at Rockefeller University, the Hilleman Lecturer at the University of Chicago, and University Lecturer at Columbia University. Racaniello has served on the editorial boards of scientific journals, including the Journal of Virology, and is a community editor for the open access journal PLOS Pathogens. He also served as the 2015 president of the American Society for Virology.
/ R8 _- Y' ~& d% `
1 M! z. f: S2 t: J8 E, R# F
附 PPT下载地址：

游客，如果您要查看本帖隐藏内容请回复

  f8 l, `% V8 M* q* M8 \

Ascovirus

棒棒哒 谢谢啦

yuhuanlibj

是新的课件吗？谢谢分享。

luil121

非常感谢

shiyou

谢谢分享~如果把往期的链接贴在最后就更好了

ipsvirus

shiyou 发表于 2017-3-31 10:57
9 ~$ X/ Z8 f, p, F8 R- E谢谢分享~如果把往期的链接贴在最后就更好了

在本版块您就可以找到

iwenfan

感谢分享

指间流沙

感谢分享！

karen3939

需要这个公开课，谢谢

wangfei2002523

下载学习学习，谢谢

genghy

未看到下载地址

Ray-V

不错 占座
) N- W& n- ?; {" L; }

Ray-V

这个系列下载地址都不存在了呢。。。求问还哪里有资源呢？

Dongzq

非常感谢。。。。

Ascovirus

棒棒哒

Ascovirus

期待视频啊

Biodog

Ray-V 发表于 2017-4-28 09:37
这个系列下载地址都不存在了呢。。。求问还哪里有资源呢？

http://virology.com.cn/thread-22913-1-1.html

vetjinzhu

查找该资源，谢谢！

chenzongxiang

谢谢分享！

tiger

Very good!!

崔晓峰

谢谢

jc123

棒棒哒，谢谢啦
* H5 B3 G2 B2 g

散文诗

谢谢分享。

Fjh

thanks

Foolmax2018

感谢分享

miaoqiuhong1989

太棒啦

agsflsfwrd

棒棒哒 谢谢