Nature Outlook: Influenza

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Influenz

Influenza kills up to 500,000 people annually. The influenza virus mutates to evade our immune system and occasionally changes drastically to become a new subtype that can start a pandemic. A century after Spanish flu killed 50 million people, Nature Outlook: Influenza examines the progress towards stopping this devastating disease.

https://www.nature.com/collections/jicdgbcgda

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Articles
Influenza
Science targets an evasive virus.

Herb Brody
OUTLOOK
18 SEP 2019
Nature

Towards a universal flu vaccine
A better understanding of the immune response to influenza is driving development of vaccines that protect against many strains of the virus.

Michael Eisenstein
OUTLOOK
18 SEP 2019
Nature

Q&A: Keeping antivirals viable
The rise of environmental resistance to the drugs used to combat flu is a potential disaster — but one that we can avert, argues Josef Järhult.

Naomi Lubick
OUTLOOK
18 SEP 2019
Nature

The push for better flu therapies
Understanding how the influenza virus replicates inside the body is helping researchers develop a wider range of antiviral drugs.

Neil Savage
OUTLOOK
18 SEP 2019
Nature

A sticking point for rapid flu tests?
Adoption of molecular tests for influenza has been slow — partly because of their high cost.

Elizabeth Svoboda
OUTLOOK
18 SEP 2019
Nature

Real-time flu tracking
By monitoring social media, scientists can monitor outbreaks as they happen.

Charles Schmidt
OUTLOOK
18 SEP 2019
Nature

Accelerating flu protection
Can the latest techniques speed up the dangerously slow production of flu vaccines?

Eric Bender
OUTLOOK
18 SEP 2019
Nature

Flu on the farm
Farms help to spread influenza but they might be an early warning system for the next human pandemic.

Cassandra Willyard
OUTLOOK
18 SEP 2019
Nature

Sanofi Pasteur: fighting influenza by improving today and innovating for tomorrow
Timothy Alefantis, Mario Barro ⋯ Jianxin Zhang
SPONSOR FEATURE
18 SEP 2019
More from Nature Research
Influenza
Influenza is an infectious respiratory disease that, in humans, is caused by influenza A and influenza B viruses. This PrimeView highlights some key preventive measures to stop its spread.

PRIMEVIEW
28 JUN 2018
Nature Reviews Disease Primers

Novel correlates of protection against pandemic H1N1 influenza A virus infection
Study of influenza virus transmission in humans provides evidence that hemagglutinin stalk-specific antibodies correlate with protection from infection.

Sophia Ng, Raffael Nachbagauer ⋯ Aubree Gordon
LETTER
3 JUN 2019
Nature Medicine

SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans
IFITM3 encodes an antiviral protein that blocks entry of influenza A virus into cells. Paul Thomas and colleagues report that SNP rs34481144 in the 5′ UTR of IFITM3 is an expression quantitative trait locus for this gene and that the risk allele is associated… show more

E Kaitlynn Allen, Adrienne G Randolph ⋯ Paul G Thomas
ARTICLE
17 JUL 2017
Nature Medicine

The biggest pandemic risk? Viral misinformation
A century after the world’s worst flu epidemic, rapid spread of misinformation is undermining trust in vaccines crucial to public health, warns Heidi Larson.

Heidi J. Larson
WORLD VIEW
16 OCT 2018
Nature

MHC class II proteins mediate cross-species entry of bat influenza viruses
The DR isotype of the human leukocyte antigen of the MHC class II—or its homologues in bats, pigs, mice and chickens—is an essential cell entry determinant for bat influenza A viruses.

Umut Karakus, Thiprampai Thamamongood ⋯ Silke Stertz
LETTER
20 FEB 2019
Nature

Entry of the bat influenza H17N10 virus into mammalian cells is enabled by the MHC class II HLA-DR receptor
A comparative transcriptional analysis identifies human HLA-DR as a factor that mediates entry of bat influenza A-like H17-pseudotyped viral particles into mammalian cells.

Efstathios S. Giotis, George Carnell ⋯ Nigel Temperton
BRIEF COMMUNICATION
29 JUL 2019
Nature Microbiology

All for one and one for all to fight flu
Antibodies have been engineered to recognize diverse strains of influenza, including both the A and B types of virus that cause human epidemics. Are we moving closer to achieving ‘universal’ protection against all flu strains?

Gary J. Nabel & John W. Shiver
NEWS & VIEWS
10 DEC 2018
Nature

Influenza
Influenza is an infectious respiratory disease that, in humans, is caused by influenza A and influenza B viruses. This Primer discusses the biological features of influenza viruses, their effects on human and animal health and the mitigation strategies to reduce the burden of this disease.

Florian Krammer, Gavin J. D. Smith ⋯ Adolfo García-Sastre
PRIMER
28 JUN 2018
Nature Reviews Disease Primers

The evolution of seasonal influenza viruses
Seasonal influenza viruses continue to cause epidemics each year. In this Review, Petrova and Russell discuss recent advances in understanding the molecular determinants of influenza virus immune escape, sources of evolutionary selection pressure, population… show more

Velislava N. Petrova & Colin A. Russell
REVIEW ARTICLE
30 OCT 2017
Nature Reviews Microbiology

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses
Antigenic variation of influenza A viruses necessitates the annual reformulation of vaccines. Kanekiyo et al. develop a mosaic nanoparticle vaccine against influenza virus that is able to elicit neutralizing antibodies that span nearly 100 years of variation of influenza A virus.

Masaru Kanekiyo, M. Gordon Joyce ⋯ Barney S. Graham
ARTICLE
11 FEB 2019
Nature Immunology

Cell culture-derived influenza vaccines in the severe 2017–2018 epidemic season: a step towards improved influenza vaccine effectiveness
Ian G. Barr, Ruben O. Donis ⋯ David E. Wentworth
PERSPECTIVE
OPEN ACCESS
9 OCT 2018
npj Vaccines

Poor adherence to influenza vaccination guidelines in spinal cord injury: results from a community-based survey in Switzerland
Elias Ronca, Melissa Miller ⋯ Christine Fekete
ARTICLE
1 AUG 2019
Spinal Cord

Time-series oligonucleotide count to assign antiviral siRNAs with long utility fit in the big data era
K Wada, Y Wada ⋯ T Ikemura
SHORT COMMUNICATION
OPEN ACCESS
14 SEP 2017
Gene Therapy

Increased risk of influenza among vaccinated adults who are obese
S D Neidich, W D Green ⋯ M A Beck
ORIGINAL ARTICLE
6 JUN 2017
International Journal of Obesity