Francis V. Chisari scripps研究所——HBV相关实验室及人物介绍...

marine0425030

1 简介
The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, California, USA
我很少看他的文章，jane200988推荐的，不过是大牛是毋庸置疑的，看看他的文章列表就知道了，偏向于HBV免疫。

2 实验室链接
http://www.scripps.edu/research/faculty.php?rec_id=335

3 研究领域
Immunobiology and Pathogenesis of Hepatitis B and C Virus Infection

The outcome of noncytolytic viral infections is largely determined by the cellular immune response. Our laboratory focusses on the host-virus interactions that determine the outcome of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. Using a combination of real time viral dynamics and quantitative functional T cell analysis, we have demonstrated a direct relationship between viral clearance and the vigor, kinetics and homing potential of the antiviral T cell response to HBV and HCV, the rate with which they spread after inoculation and their ability to escape immune recognition. In addition, we have shown that there is a third effector limb in the immune response besides antibody neutralization and T cell-mediated destruction of infected cells: i.e. T cells also secrete antiviral cytokines that can purge viruses from infected cells without killing them. Currently we are applying genome-wide expression profiling to define the intracellular antiviral effector pathways that are triggered by these cytokines; biochemical, biophysical and molecular approaches to identify the points in the life cycles of these viruses that are targeted by these antiviral cytokines; and molecular immunological strategies to determine the mechanisms deployed by the viruses to defeat their antiviral effects.

4 文章
太多了，去他主页自己看吧
McClary, H., Koch, R., Chisari, F.V., and Guidotti, L.G. Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines. J. Virol. 74:2255-2264, 2000.

Chisari, F.V.  Rous-Whipple Award Lecture.  Viruses, Immunity, and Cancer:  Lessons from Hepatitis B.  Am. J. Pathol. 159:1117-1131, 2000.

Wieland, S.F., Guidotti, L.G., and Chisari, F.V. Intrahepatic induction of alpha/beta interferon eliminates viral RNA-containing capsids in HBV transgenic mice. J. Virol. 74:4165-4173, 2000.

Schirmbeck, R., Wild, J., Blum, H.E., Chisari, F.V., Geissler, M., and Reimann, J. Ongoing murine T1 or T2 immune responses to the hepatitis B surface antigen (HBsAg) are excluded from the liver that expresses transgene-encoded HBsAg. J. Immunol. 164:4235-4243, 2000.

Guidotti, L.G., McClary, H., Moorhead, J., and Chisari, F.V. Nitric oxide inhibits hepatitis B virus replication in the liver of transgenic mice. J. Exp. Med. 191:1247-1252, 2000.

McClary, H., Koch, R., Chisari, F.V., and Guidotti, L.G.  Inhibition of hepatitis B virus replication during Schistosoma Mansoni infection in transgenic mice.  J. Exp. Med. 192:289-294, 2000.

Guidotti, L.G. and Chisari, F.V.  Cytokine-mediated control of viral infections.  In: Virology 273:221-226, 2000.

Pasquetto, V., Guidotti, L.G., Kakimi, K., Koch, R., Tsjui, M., and Chisari, F.V.  Host-virus interaction during malaria infection in hepatitis B virus transgenic mice.  J. Exp. Med. 192:529-535, 2000.

Voehringer, D., Blaser, C., Busse-Grawitz, A., Chisari, F.V., Buerki, K., and Pircher, H.  Break of T cell ignorance to a viral antigen in the liver induces hepatitis.  J. Immunol. 165:2415-2423, 2000.

Pasquetto, V., Wieland, S., and Chisari, F.V.  Intracellular Hepatitis B Virus nucleocapsids survive cytotoxic T-Lymphocyte induced apoptosis. J. Virol.74:9792-9796, 2000.

Kakimi, K., Guidotti L., Koezuka, Y., and Chisari F.V.  Natural killer T cell activation inhibits hepatitis B virus replication in vivo. J. Exp. Med. 192:921-930, 2000.

McKinney, D.M., Erickson, A.L., Walker, C.M., Thimme, R., Chisari, F.V., Purcell, R., Sidney, J., and Sette, A.  Identification of five different Patr class I molecules which bind HLA supertype peptides and definition of their peptide binding motifs. J. Immunol. 165:4414-4422, 2000.

Forns, X., Thimme, R., Govindarajan, S., Emerson, S.U., Purcell, R.H., Chisari, F.V., and Bukh, J.  Hepatitis C Virus lacking hypervariable region 1 of the second envelope protein is infectious and causes acute resolving or persistent infection in chimpanzees.  Proc. Nat'l. Acad. Sci. USA 97:13318-13323, 2000.

Guidotti, L.G. and Chisari, F.V.  Noncytolytic control of viral infections by the innate and adaptive immune response.  Annu. Rev. Immunol. 19:65-91, 2001.

Chang, K-M., Thimme, R., Melpolder, J., Oldach, D., Pemberton, J., Moorhead-Loudis, J., McHutchison, J.G., Alter, H.J., and Chisari, F.V. Differential CD4+ and CD8+ T cell responsiveness in hepatitis C virus infection.  Hepatology  33:267-276, 2001.

Sette, A., Oseroff, C., Sidney, J.,  Alexander, J., Chesnut, R.W., Kakimi, K., Guidotti, L.G., and Chisari, F.V.  Overcoming T cell tolerance to the hepatitis B virus surface antigen in Hepatitis B Virus-transgenic mice.  J. Immunol. 166:1389-1397, 2001.

Schirmbeck, R., Zheng, X., Roggendorf, M., Geissler, M., Chisari, F.V., Reimann, J., and Lu, M.  Targeting murine immune responses to selected T cell- or antibody-defined determinants of the hepatitis B surface antigen (hBsAg) by plasmid DNA vaccines encoding chimeric antigen.  J. Immunol. 166:1405-1413, 2001.

Thimme, R., Chang, K.M., Pemberton, J., Sette, A., and Chisari, F.V.  Degenerate Immunogenicity of an HLA-A*0201-restricted HBV nucleocapid CTL epitope that is also presented by HLA-B*5101.  J. Virol. 75:3984-3987, 2001.

Ferrari, C. and Chisari, F.V.  Immune mechanisms of viral clearance and disease pathogenesis during viral hepatitis. In: The Liver: Biology and Pathobiology 4th Edition.  Arias, I.M., Boyer, J., Chisari, F.V., Fausto, N., Schachter,  and Shafritz, D. (Eds.).  Lippincott, Williams & Wilkins, Philadelphia, PA, pp. 763-782, 2001.

Heise, T., Guidotti, L.G., and Chisari, F.V.  Characterization of nuclear ribonucleases that cleave hepatitis B virus RNA near the La protein binding site.  J. Virol. 75:6874-6883, 2001.

Thimme, R., Oldach, D., Chang, K.M., Steiger, C., Ray, S., and Chisari, F.V.  Determinants of viral clearance and persistence during acute HCV infection.  J. Exp. Med. 194:1395-1406, 2001.

Kakimi, K., Lane, T.E., Chisari, F.V., and Guidotti, L.G. Inhibition of hepatitis B virus replication by activated NKT cells does not require inflammatory cell recruitment to the liver.   J. Immunol. 167:6701-6705, 2001.

Kakimi, K., Campbell, I., Lane, T., Wieland, S.F., Chisari, F.V., and Guidotti, L.G.  Blocking chemokine responsive to g-2/interferon (IFN)-g inducible protein and monokine induced by IFN-g activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes.  J. Exp. Med. 194:1755-1766, 2001.

Mosier, D.E. and Chisari, F.V.  GB and virus C and mortality from HIV infection.  N. Engl. J. Med. 346:377-379, 2002.

Guidotti LG, Morris A, Mendez H, Koch R, Silverman RH, Williams BR, and Chisari FV. Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice.
J Virol. 76:2617-21, 2002.

Robek, M.D., Wieland, S.F., and Chisari, F.V.  Inhibition of hepatitis B virus replication by interferon requires proteasome activity. J. Virol. 76:3570-3574, 2002.

Pasquetto, V., Wieland, S.F., Uprichard, S.L., Tripodi, M., and Chisari, F.V.  Cytokine sensitive replication of hepatitis B virus in immortalized mouse hepatocyte cultures.


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