求帮忙下这篇文献

zszhao

http://www.nature.com/ni/journal/v13/n6/full/ni.2301.html顺便下一下补充的pdf

marine0425030

Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling

3 Y0 m. b, d, O$ w8 M1 n Di Wang,        Mingzhu Zheng,        Lei Lei,        Jian Ji,        Yunliang Yao,        Yuanjun Qiu,        Lie Ma,        Jun Lou,        Chuan Ouyang,        Xue Zhang,        Yuewei He,        Jun Chi,        Lie Wang,        Ying Kuang,        Jianli Wang,        Xuetao Cao        & Linrong Lu

$ J0 O/ e, r2 }. b. V' H6 P4 I* SSignaling via the T cell antigen receptor (TCR) during the CD4+CD8+ double-positive developmental stage determines thymocyte selection and lineage commitment. Here we describe a previously uncharacterized T cell–expressed protein, Tespa1, with critical functions during the positive selection of thymocytes. Tespa1−/− mice had fewer mature thymic CD4+ and CD8+ T cells, which reflected impaired thymocyte development. Tespa1 associated with the TCR signaling components PLC-γ1 and Grb2, and Tespa1 deficiency resulted in attenuated TCR signaling, as reflected by defective activation of the Erk–AP-1 and Ca2+-NFAT pathways. Our findings demonstrate that Tespa1 is a component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development.

鲁教授又出好文章了。

ipsvirus

文件有点大，留个邮箱吧，我发你

zszhao

ipsvirus 发表于 2015-11-18 11:04
文件有点大，留个邮箱吧，我发你

; ]8 }6 o/ w, r4 \1455710563@qq.com，谢谢啦

zszhao

marine0425030 发表于 2015-11-18 09:34
Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling
) G) t$ X3 F* B+ d
  ...

8 x; ?. L5 L! G$ e! K1 {未来的老板

ipsvirus

zszhao 发表于 2015-11-19 13:09
" N4 Z& m7 S6 P# {0 P+ V，谢谢啦

6 Y) S4 l, o) w3 v* ]7 i9 _4 \已发，请查收