求帮忙下这篇文献

zszhao

http://www.nature.com/ni/journal/v13/n6/full/ni.2301.html顺便下一下补充的pdf
0 l' b- ?; W- Y. w! X

marine0425030

Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling
. q/ ]" j/ _, t9 Q3 T" {
, B' Z& Y" D" ^9 h# u Di Wang,        Mingzhu Zheng,        Lei Lei,        Jian Ji,        Yunliang Yao,        Yuanjun Qiu,        Lie Ma,        Jun Lou,        Chuan Ouyang,        Xue Zhang,        Yuewei He,        Jun Chi,        Lie Wang,        Ying Kuang,        Jianli Wang,        Xuetao Cao        & Linrong Lu

0 G$ T+ V6 G3 l$ }* _( I4 K) NSignaling via the T cell antigen receptor (TCR) during the CD4+CD8+ double-positive developmental stage determines thymocyte selection and lineage commitment. Here we describe a previously uncharacterized T cell–expressed protein, Tespa1, with critical functions during the positive selection of thymocytes. Tespa1−/− mice had fewer mature thymic CD4+ and CD8+ T cells, which reflected impaired thymocyte development. Tespa1 associated with the TCR signaling components PLC-γ1 and Grb2, and Tespa1 deficiency resulted in attenuated TCR signaling, as reflected by defective activation of the Erk–AP-1 and Ca2+-NFAT pathways. Our findings demonstrate that Tespa1 is a component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development.
2 c/ M7 `8 c8 N6 J& ^, M
  e( K6 R& V! _; j1 q7 n% u  r& j3 [鲁教授又出好文章了。

ipsvirus

文件有点大，留个邮箱吧，我发你

zszhao

ipsvirus 发表于 2015-11-18 11:04
7 b' ~2 @' l! T% f* j" A: d9 i, i% S2 c文件有点大，留个邮箱吧，我发你

" v4 x* E; z! f' B# g* ^& h% b  ?: w1455710563@qq.com，谢谢啦

zszhao

marine0425030 发表于 2015-11-18 09:34
. {: u2 y1 z% e. \6 `) UTespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling
5 B7 Y  l/ Z8 ^( l, \
* u8 y6 g1 W) k) w$ W" l  ...

7 I3 I5 [" y5 b; A( h2 m未来的老板

ipsvirus

zszhao 发表于 2015-11-19 13:09
- M. C1 _& {: D6 K; k，谢谢啦

- r) u5 V; J  v已发，请查收