|
|
Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling
4 X/ w6 j: X; j; S4 m
$ F4 A0 p. ~% Y1 |5 a Di Wang, Mingzhu Zheng, Lei Lei, Jian Ji, Yunliang Yao, Yuanjun Qiu, Lie Ma, Jun Lou, Chuan Ouyang, Xue Zhang, Yuewei He, Jun Chi, Lie Wang, Ying Kuang, Jianli Wang, Xuetao Cao & Linrong Lu
, ?* f3 n9 t% ~! U1 \. X) B; F9 |* L& k8 V
; V5 Z; J0 D. u" [2 U& W0 ^Signaling via the T cell antigen receptor (TCR) during the CD4+CD8+ double-positive developmental stage determines thymocyte selection and lineage commitment. Here we describe a previously uncharacterized T cell–expressed protein, Tespa1, with critical functions during the positive selection of thymocytes. Tespa1−/− mice had fewer mature thymic CD4+ and CD8+ T cells, which reflected impaired thymocyte development. Tespa1 associated with the TCR signaling components PLC-γ1 and Grb2, and Tespa1 deficiency resulted in attenuated TCR signaling, as reflected by defective activation of the Erk–AP-1 and Ca2+-NFAT pathways. Our findings demonstrate that Tespa1 is a component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development.
: a6 Q- u( S+ N {9 C% v( j6 d" s5 L: b: w, D, Y) y# K
鲁教授又出好文章了。 |
|
发表于 2015-11-17 22:50:45
QQ好友和群
QQ空间
腾讯微博
腾讯朋友
收藏
分享
支持
反对
发表于 2015-11-18 11:04:50
楼主
