Michael Nassal，Freiburg，德国——HBV相关实验室及人物介绍系列

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Michael Nassal，Freiburg，德国——HBV相关实验室及人物介绍系列
研究乙肝复制，位于University Hospital Freiburg，德国

Verrier, E. R. and C. C. Colpitts, et al. (2016). "A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses." Hepatology 63(1): 35-48.
Hoh, A. and M. Heeg, et al. (2015). "Hepatitis B Virus-Infected HepG2hNTCP Cells Serve as a Novel Immunological Tool To Analyze the Antiviral Efficacy of CD8+ T Cells In Vitro." J Virol 89(14): 7433-8.
Nassal, M. (2015). "HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B." Gut 64(12): 1972-84.
Baumert, T. F. and E. R. Verrier, et al. (2015). "Host-targeting agents for treatment of hepatitis B virus infection." Curr Opin Virol 14: 41-6.
Cheng, X. and W. Guan, et al. (2015). "Stable Human Hepatoma Cell Lines for Efficient Regulated Expression of Nucleoside/Nucleotide Analog Resistant and Vaccine Escape Hepatitis B Virus Variants and Woolly Monkey Hepatitis B Virus." PLoS One 10(12): e0145746.
Kolb, P. and R. Wallich, et al. (2015). "Whole-Chain Tick Saliva Proteins Presented on Hepatitis B Virus Capsid-Like Particles Induce High-Titered Antibodies with Neutralizing Potential." PLoS One 10(9): e0136180.
Ni, Y. and F. A. Lempp, et al. (2014). "Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes." Gastroenterology 146(4): 1070-83.
Thimme, R. and M. Heim, et al. (2014). "[Hepatitis B and C: From molecular virology to new antiviral therapies (part 1)]." Dtsch Med Wochenschr 139(13): 655-9.
Thimme, R. and M. Heim, et al. (2014). "[Hepatitis B and C: from molecular virology to new antiviral therapies (part 2)]." Dtsch Med Wochenschr 139(15): 778-82.
Lange, M. and M. Fiedler, et al. (2014). "Hepatitis C virus hypervariable region 1 variants presented on hepatitis B virus  capsid-like particles induce cross-neutralizing antibodies." PLoS One 9(7): e102235.
Koniger, C. and I. Wingert, et al. (2014). "Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses." Proc Natl Acad Sci U S A 111(40): E4244-53.
Liu, J. and X. Cheng, et al. (2013). "Truncated active human matrix metalloproteinase-8 delivered by a chimeric adenovirus-hepatitis B virus vector ameliorates rat liver cirrhosis." PLoS One 8(1): e53392.
Wang, Z. and L. Wu, et al. (2013). "Replication-competent infectious hepatitis B virus vectors carrying substantially sized transgenes by redesigned viral polymerase translation." PLoS One 8(4): e60306.
Feng, H. and P. Chen, et al. (2013). "Evidence for multiple distinct interactions between hepatitis B virus P protein and its cognate RNA encapsidation signal during initiation of reverse transcription." PLoS One 8(8): e72798.
Wang, Y. X. and C. Luo, et al. (2012). "Extensive mutagenesis of the conserved box E motif in duck hepatitis B virus P protein reveals multiple functions in replication and a common structure with the primer grip in HIV-1 reverse transcriptase." J Virol 86(12): 6394-407.
Kock, J. and C. Rosler, et al. (2012). "Human hepatitis B virus production in avian cells is characterized by enhanced RNA splicing and the presence of capsids containing shortened genomes." PLoS One 7(5): e37248.
Schmid, B. and C. Rosler, et al. (2011). "A high level of mutation tolerance in the multifunctional sequence encoding the RNA encapsidation signal of an avian hepatitis B virus and slow evolution rate revealed by in vivo infection." J Virol 85(18): 9300-13.
Feng, H. and J. Beck, et al. (2011). "A SELEX-screened aptamer of human hepatitis B virus RNA encapsidation signal suppresses viral replication." PLoS One 6(11): e27862.
Kock, J. and C. Rosler, et al. (2010). "Generation of covalently closed circular DNA of hepatitis B viruses via intracellular recycling is regulated in a virus specific manner." PLoS Pathog 6(9): e1001082.
Schaedler, S. and J. Krause, et al. (2010). "Hepatitis B virus induces expression of antioxidant response element-regulated genes by activation of Nrf2." J Biol Chem 285(52): 41074-86.
Porterfield, J. Z. and M. S. Dhason, et al. (2010). "Full-length hepatitis B virus core protein packages viral and heterologous RNA with similarly high levels of cooperativity." J Virol 84(14): 7174-84.
Sun, D. and C. Rosler, et al. (2010). "Quantitative assessment of the antiviral potencies of 21 shRNA vectors targeting  conserved, including structured, hepatitis B virus sites." J Hepatol 52(6): 817-26.
Bellecave, P. and J. Gouttenoire, et al. (2009). "Hepatitis B and C virus coinfection: a novel model system reveals the absence of  direct viral interference." Hepatology 50(1): 46-55.
Walker, A. and C. Skamel, et al. (2008). "Internal core protein cleavage leaves the hepatitis B virus capsid intact and enhances its capacity for surface display of heterologous whole chain proteins." J Biol Chem 283(48): 33508-15.
Nassal, M. (2008). "Hepatitis B viruses: reverse transcription a different way." Virus Res 134(1-2): 235-49.
Halverscheid, L. and N. K. Mannes, et al. (2008). "Transgenic mice replicating hepatitis B virus but lacking expression of the major HBsAg." J Med Virol 80(4): 583-90.
Nassal, M. and C. Skamel, et al. (2008). "Development of hepatitis B virus capsids into a whole-chain protein antigen display platform: new particulate Lyme disease vaccines." Int J Med Microbiol 298(1-2): 135-42.
Nassal, M. and I. Leifer, et al. (2007). "A structural model for duck hepatitis B virus core protein derived by extensive mutagenesis." J Virol 81(23): 13218-29.
Vorreiter, J. and I. Leifer, et al. (2007). "Monoclonal antibodies providing topological information on the duck hepatitis B virus core protein and avihepadnaviral nucleocapsid structure." J Virol 81(23): 13230-4.
Beck, J. and M. Nassal (2007). "Hepatitis B virus replication." World J Gastroenterol 13(1): 48-64.
Christen, V. and F. Duong, et al. (2007). "Inhibition of alpha interferon signaling by hepatitis B virus." J Virol 81(1): 159-65.
Bottcher, B. and M. Vogel, et al. (2006). "High plasticity of the hepatitis B virus capsid revealed by conformational stress." J Mol Biol 356(3): 812-22.
Skamel, C. and M. Ploss, et al. (2006). "Hepatitis B virus capsid-like particles can display the complete, dimeric outer surface protein C and stimulate production of protective antibody responses against Borrelia burgdorferi infection." J Biol Chem 281(25): 17474-81.
Sun, D. and M. Nassal (2006). "Stable HepG2- and Huh7-based human hepatoma cell lines for efficient regulated expression of infectious hepatitis B virus." J Hepatol 45(5): 636-45.
Vogel, M. and J. Vorreiter, et al. (2005). "Quaternary structure is critical for protein display on capsid-like particles (CLPs): efficient generation of hepatitis B virus CLPs presenting monomeric but not dimeric and tetrameric fluorescent proteins." Proteins 58(2): 478-88.
Nassal, M. and C. Skamel, et al. (2005). "A fusion product of the complete Borrelia burgdorferi outer surface protein A (OspA) and the hepatitis B virus capsid protein is highly immunogenic and induces protective immunity similar to that seen with an effective lipidated OspA vaccine formula." Eur J Immunol 35(2): 655-65.
Vogel, M. and M. Diez, et al. (2005). "In vitro assembly of mosaic hepatitis B virus capsid-like particles (CLPs): rescue into CLPs of assembly-deficient core protein fusions and FRET-suited CLPs." FEBS Lett 579(23): 5211-6.
Baumert, T. F. and C. Yang, et al. (2005). "Hepatitis B virus mutations associated with fulminant hepatitis induce apoptosis  in primary Tupaia hepatocytes." Hepatology 41(2): 247-56.
Nassal, M. and K. Dallmeier, et al. (2005). "Phenotyping hepatitis B virus variants: from transfection towards a small animal  in vivo infection model." J Clin Virol 34 Suppl 1: S89-95.
Hu, K. and J. Beck, et al. (2004). "SELEX-derived aptamers of the duck hepatitis B virus RNA encapsidation signal distinguish critical and non-critical residues for productive initiation of reverse transcription." Nucleic Acids Res 32(14): 4377-89.
Jacquard, A. C. and M. Nassal, et al. (2004). "Effect of a combination of clevudine and emtricitabine with adenovirus-mediated delivery of gamma interferon in the woodchuck model of hepatitis B virus infection." Antimicrob Agents Chemother 48(7): 2683-92.
Schultz, U. and E. Grgacic, et al. (2004). "Duck hepatitis B virus: an invaluable model system for HBV infection." Adv Virus Res 63: 1-70.
Kock, J. and M. Nassal, et al. (2004). "Hepatitis B virus nucleocapsids formed by carboxy-terminally mutated core proteins contain spliced viral genomes but lack full-size DNA." J Virol 78(24): 13812-8.
Beck, J. and M. Nassal (2004). "In vitro reconstitution of epsilon-dependent duck hepatitis B virus replication initiation." Methods Mol Med 95: 315-25.
von Weizsacker, F. and J. Kock, et al. (2004). "The tupaia model for the study of hepatitis B virus: direct infection and HBV genome transduction of primary tupaia hepatocytes." Methods Mol Med 96: 153-61.
Beck, J. and M. Nassal (2003). "Efficient Hsp90-independent in vitro activation by Hsc70 and Hsp40 of duck hepatitis B virus reverse transcriptase, an assumed Hsp90 client protein." J Biol Chem 278(38): 36128-38.
Nassal, M. (2002). "Ca2+: the clue to hepatitis B virus X protein function?" Hepatology 36(3): 755-7.
Pumpens, P. and E. Grens, et al. (2002). "Molecular epidemiology and immunology of hepatitis B virus infection - an update." Intervirology 45(4-6): 218-32.
Beck, J. and M. Vogel, et al. (2002). "dNTP versus NTP discrimination by phenylalanine 451 in duck hepatitis B virus P protein indicates a common structure of the dNTP-binding pocket with other reverse transcriptases." Nucleic Acids Res 30(7): 1679-87.
von Weizsacker, F. and J. Kock, et al. (2002). "Cis-preferential recruitment of duck hepatitis B virus core protein to the RNA/polymerase preassembly complex." Hepatology 35(1): 209-16.
Chouteau, P. and J. Le Seyec, et al. (2001). "A short N-proximal region in the large envelope protein harbors a determinant that contributes to the species specificity of human hepatitis B virus." J Virol 75(23): 11565-72.
Beck, J. and M. Nassal (2001). "Reconstitution of a functional duck hepatitis B virus replication initiation complex from separate reverse transcriptase domains expressed in Escherichia coli." J Virol 75(16): 7410-9.
Kock, J. and M. Nassal, et al. (2001). "Efficient infection of primary tupaia hepatocytes with purified human and woolly  monkey hepatitis B virus." J Virol 75(11): 5084-9.
Ren, S. and M. Nassal (2001). "Hepatitis B virus (HBV) virion and covalently closed circular DNA formation in primary tupaia hepatocytes and human hepatoma cell lines upon HBV genome transduction with replication-defective adenovirus vectors." J Virol 75(3): 1104-16.
Beterams, G. and M. Nassal (2001). "Significant interference with hepatitis B virus replication by a core-nuclease fusion protein." J Biol Chem 276(12): 8875-83.
Beterams, G. and B. Bottcher, et al. (2000). "Packaging of up to 240 subunits of a 17 kDa nuclease into the interior of recombinant hepatitis B virus capsids." FEBS Lett 481(2): 169-76.
Nassal, M. (1999). "Hepatitis B virus replication: novel roles for virus-host interactions." Intervirology 42(2-3): 100-16.
Protzer, U. and M. Nassal, et al. (1999). "Interferon gene transfer by a hepatitis B virus vector efficiently suppresses wild-type virus infection." Proc Natl Acad Sci U S A 96(19): 10818-23.
Kratz, P. A. and B. Bottcher, et al. (1999). "Native display of complete foreign protein domains on the surface of hepatitis B  virus capsids." Proc Natl Acad Sci U S A 96(5): 1915-20.
Schaaf, S. G. and J. Beck, et al. (1999). "A small 2'-OH- and base-dependent recognition element downstream of the initiation site in the RNA encapsidation signal is essential for hepatitis B virus replication initiation." J Biol Chem 274(53): 37787-94.
Beck, J. and M. Nassal (1998). "Formation of a functional hepatitis B virus replication initiation complex involves a major structural alteration in the RNA template." Mol Cell Biol 18(11): 6265-72.
Ulrich, R. and M. Nassal, et al. (1998). "Core particles of hepatitis B virus as carrier for foreign epitopes." Adv Virus Res 50: 141-82.
Konig, S. and G. Beterams, et al. (1998). "Mapping of homologous interaction sites in the hepatitis B virus core protein." J Virol 72(6): 4997-5005.
Beck, J. and M. Nassal (1997). "Sequence- and structure-specific determinants in the interaction between the RNA  encapsidation signal and reverse transcriptase of avian hepatitis B viruses." J Virol 71(7): 4971-80.
Nassal, M. (1997). "Novel molecular approaches toward therapy of chronic hepatitis B." Arch Virol 142(3): 611-28.
Beck, J. and H. Bartos, et al. (1997). "Experimental confirmation of a hepatitis B virus (HBV) epsilon-like bulge-and-loop structure in avian HBV RNA encapsidation signals." Virology 227(2): 500-4.
Rieger, A. and M. Nassal (1996). "Specific hepatitis B virus minus-strand DNA synthesis requires only the 5' encapsidation signal and the 3'-proximal direct repeat DR1." J Virol 70(1): 585-9.
Beck, J. and M. Nassal (1996). "A sensitive procedure for mapping the boundaries of RNA elements binding in vitro translated proteins defines a minimal hepatitis B virus encapsidation signal." Nucleic Acids Res 24(21): 4364-6.
Nassal, M. and H. Schaller (1996). "Hepatitis B virus replication--an update." J Viral Hepat 3(5): 217-26.
Nassal, M. and A. Rieger (1996). "A bulged region of the hepatitis B virus RNA encapsidation signal contains the replication origin for discontinuous first-strand DNA synthesis." J Virol 70(5): 2764-73.
Nassal, M. (1996). "Hepatitis B virus morphogenesis." Curr Top Microbiol Immunol 214: 297-337.
Beck, J. and M. Nassal (1995). "Efficient hammerhead ribozyme-mediated cleavage of the structured hepatitis B virus encapsidation signal in vitro and in cell extracts, but not in intact cells." Nucleic Acids Res 23(24): 4954-62.
Kenney, J. M. and C. H. von Bonsdorff, et al. (1995). "Evolutionary conservation in the hepatitis B virus core structure: comparison of  human and duck cores." Structure 3(10): 1009-19.
Rieger, A. and M. Nassal (1995). "Distinct requirements for primary sequence in the 5'- and 3'-part of a bulge in the hepatitis B virus RNA encapsidation signal revealed by a combined in vivo selection/in vitro amplification system." Nucleic Acids Res 23(19): 3909-15.
Nassal, M. and H. Schaller (1993). "Hepatitis B virus replication." Trends Microbiol 1(6): 221-8.
Knaus, T. and M. Nassal (1993). "The encapsidation signal on the hepatitis B virus RNA pregenome forms a stem-loop structure that is critical for its function." Nucleic Acids Res 21(17): 3967-75.
Nassal, M. and A. Rieger (1993). "An intramolecular disulfide bridge between Cys-7 and Cys61 determines the structure of the secretory core gene product (e antigen) of hepatitis B virus." J Virol 67(7): 4307-15.
Lamberts, C. and M. Nassal, et al. (1993). "Precore-mediated inhibition of hepatitis B virus progeny DNA synthesis." J Virol 67(7): 3756-62.
Broker, M. and M. Noah, et al. (1993). "Expression of hepatitis B virus core gene products with specific immunoreactivity for e antigen (HBeAg) in Saccharomyces cerevisiae." J Biotechnol 29(3): 243-55.
Bichko, V. and F. Schodel, et al. (1993). "Epitopes recognized by antibodies to denatured core protein of hepatitis B virus." Mol Immunol 30(3): 221-31.
Nassal, M. (1992). "Conserved cysteines of the hepatitis B virus core protein are not required for assembly of replication-competent core particles nor for their envelopment." Virology 190(1): 499-505.
Nassal, M. (1992). "The arginine-rich domain of the hepatitis B virus core protein is required for pregenome encapsidation and productive viral positive-strand DNA synthesis but not for virus assembly." J Virol 66(7): 4107-16.
Nassal, M. and A. Rieger, et al. (1992). "Topological analysis of the hepatitis B virus core particle by cysteine-cysteine  cross-linking." J Mol Biol 225(4): 1013-25.
Birnbaum, F. and M. Nassal (1990). "Hepatitis B virus nucleocapsid assembly: primary structure requirements in the core protein." J Virol 64(7): 3319-30.
Nassal, M. and P. R. Galle, et al. (1989). "Proteaselike sequence in hepatitis B virus core antigen is not required for e antigen generation and may not be part of an aspartic acid-type protease." J Virol 63(6): 2598-604.
Nassal, M. (1988). "Total chemical synthesis of a gene for hepatitis B virus core protein and its functional characterization." Gene 66(2): 279-94.
Nassal, M. and L. Theilmann, et al. (1987). "Rapid procedure for the detection of hepatitis delta virus RNA in sera of HBsAg-positive and anti-delta-positive patients." Arzneimittelforschung 37(6): 748-51.