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袁正宏,复旦大学,上海——HBV相关实验室及人物介绍系列
袁正宏,复旦大学,复旦大学上海医学院,上海
乙肝天然免疫
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Chen, J. and W. Zhang, et al. (2014). "An efficient antiviral strategy for targeting hepatitis B virus genome using transcription activator-like effector nucleases." Mol Ther 22(2): 303-11.
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Ren, H. and J. Li, et al. (2013). "The development of a combined mathematical model to forecast the incidence of hepatitis E in Shanghai, China." BMC Infect Dis 13: 421.
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Wang, S. and Z. Chen, et al. (2013). "Hepatitis B virus surface antigen selectively inhibits TLR2 ligand-induced IL-12 production in monocytes/macrophages by interfering with JNK activation." J Immunol 190(10): 5142-51.
Liang, S. Q. and Du J, et al. (2013). "A mouse model for studying the clearance of hepatitis B virus in vivo using a luciferase reporter." PLoS One 8(4): e60005.
Wang, H. and Z. Yuan, et al. (2013). "Eight novel hepatitis C virus genomes reveal the changing taxonomic structure of genotype 6." J Gen Virol 94(Pt 1): 76-80.
Chen, J. and M. Wu, et al. (2013). "Hepatitis B virus polymerase impairs interferon-alpha-induced STA T activation through inhibition of importin-alpha5 and protein kinase C-delta." Hepatology 57(2): 470-82.
Chen, Q. Y. and Y. H. Liu, et al. (2012). "DNA-dependent activator of interferon-regulatory factors inhibits hepatitis B virus replication." World J Gastroenterol 18(22): 2850-8.
Hu, J. L. and J. Cui, et al. (2012). "Phenotypic assay of a hepatitis B virus strain carrying an rtS246T variant using a new strategy." J Med Virol 84(1): 34-43.
Wang, S. and X. Wu, et al. (2012). "Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33." J Gen Virol 93(Pt 1): 83-92.
Jia, X. F. and W. Lu, et al. (2012). "[Plasma proteome analysis of chronic hepatitis B patients with different stages of liver fibrosis]." Zhonghua Gan Zang Bing Za Zhi 20(9): 659-63.
Zhang, X. and C. Chen, et al. (2012). "Plasma microRNA profile as a predictor of early virological response to interferon treatment in chronic hepatitis B patients." Antivir Ther 17(7): 1243-53.
Ren, G. and S. Esser, et al. (2012). "Interleukin 21 augments the hepatitis B virus-specific CD8+ T-cell response in vitro in patients coinfected with HIV-1." AIDS 26(17): 2145-53.
Wang, Z. and J. Ni, et al. (2011). "Inhibition of hepatitis B virus replication by cIAP2 involves accelerating the ubiquitin-proteasome-mediated destruction of polymerase." J Virol 85(21): 11457-67.
Wang, Y. and Y. Wang, et al. (2011). "Hepatitis C virus NS5B protein delays s phase progression in human hepatocyte-derived cells by relocalizing cyclin-dependent kinase 2-interacting protein (CINP)." J Biol Chem 286(30): 26603-15.
Li, J. and Y. Liu, et al. (2011). "Subversion of cellular autophagy machinery by hepatitis B virus for viral envelopment." J Virol 85(13): 6319-33.
Yi, Z. and T. Pan, et al. (2011). "Hepatitis C virus co-opts Ras-GTPase-activating protein-binding protein 1 for its genome replication." J Virol 85(14): 6996-7004.
Yao, X. and X. Y. Wang, et al. (2011). "Transcriptional analysis of immune-related genes in dendritic cells from hepatitis B surface antigen (HBsAg)-positive transgenic mice and regulation of Fc gamma receptor IIB by HBsAg-anti-HBs complex." J Med Virol 83(1): 78-87.
Wang, X. Y. and X. X. Zhang, et al. (2010). "Serum HBeAg sero-conversion correlated with decrease of HBsAg and HBV DNA in chronic hepatitis B patients treated with a therapeutic vaccine." Vaccine 28(51): 8169-74.
Zhang, L. and X. Jia, et al. (2010). "Development and validation of a liquid chromatography-mass spectrometry metabonomic platform in human plasma of liver failure caused by hepatitis B virus." Acta Biochim Biophys Sin (Shanghai) 42(10): 688-98.
Peng, L. and D. Liang, et al. (2010). "Hepatitis C virus NS5A activates the mammalian target of rapamycin (mTOR) pathway, contributing to cell survival by disrupting the interaction between FK506-binding protein 38 (FKBP38) and mTOR." J Biol Chem 285(27): 20870-81.
Li, J. and S. Lin, et al. (2010). "Inhibition of hepatitis B virus replication by MyD88 involves accelerated degradation of pregenomic RNA and nuclear retention of pre-S/S RNAs." J Virol 84(13): 6387-99.
Yu, S. and J. Chen, et al. (2010). "Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3." J Gen Virol 91(Pt 8): 2080-90.
Zhao, C. and W. Zhang, et al. (2010). "Proteomic analysis of cell lines expressing small hepatitis B surface antigen revealed decreased glucose-regulated protein 78 kDa expression in association with higher susceptibility to apoptosis." J Med Virol 82(1): 14-22.
Bian, G. and Y. Cheng, et al. (2009). "Whole recombinant Hansenula polymorpha expressing hepatitis B virus surface antigen (yeast-HBsAg) induces potent HBsAg-specific Th1 and Th2 immune responses." Vaccine 28(1): 187-94.
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Chen, Z. and Y. Cheng, et al. (2008). "Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients." Clin Immunol 128(3): 400-8.
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Wu, M. and Y. Xu, et al. (2007). "Hepatitis B virus polymerase inhibits the interferon-inducible MyD88 promoter by blocking nuclear translocation of Stat1." J Gen Virol 88(Pt 12): 3260-9.
Ma, K. and W. Xu, et al. (2007). "Coimmunization with RANTES plasmid polarized Th1 immune response against hepatitis B virus envelope via recruitment of dendritic cells." Antiviral Res 76(2): 140-9.
Yao, X. and B. Zheng, et al. (2007). "Therapeutic effect of hepatitis B surface antigen-antibody complex is associated with cytolytic and non-cytolytic immune responses in hepatitis B patients." Vaccine 25(10): 1771-9.
Yi, Z. and C. Fang, et al. (2006). "Subproteomic study of hepatitis C virus replicon reveals Ras-GTPase-activating protein binding protein 1 as potential HCV RC component." Biochem Biophys Res Commun 350(1): 174-8.
Wang, J. and W. Tong, et al. (2006). "Hepatitis C virus non-structural protein NS5A interacts with FKBP38 and inhibits apoptosis in Huh7 hepatoma cells." FEBS Lett 580(18): 4392-400.
Liu, S. A. and D. Z. Xu, et al. (2006). "[Immune response for phase I clinical trial of a hepatitis B immunogenic complex therapeutic vaccine, YIC]." Zhonghua Gan Zang Bing Za Zhi 14(2): 89-92.
Qian, B. and H. Shen, et al. (2006). "Expression and purification of the synthetic preS1 gene of Hepatitis B Virus with preferred Escherichia coli codon preference." Protein Expr Purif 48(1): 74-80.
Fang, C. and Z. Yi, et al. (2006). "Proteome analysis of human liver carcinoma Huh7 cells harboring hepatitis C virus subgenomic replicon." Proteomics 6(2): 519-27.
Wang, H. and X. T. Shen, et al. (2005). "Roles of the polypyrimidine tract and 3' noncoding region of hepatitis C virus RNA in the internal ribosome entry site-mediated translation." Arch Virol 150(6): 1085-99.
Lin, X. and Z. M. Ma, et al. (2005). "Substitution of proline 306 in the reverse transcriptase domain of hepatitis B virus regulates replication." J Gen Virol 86(Pt 1): 85-90.
Mao, H. X. and Y. W. Hu, et al. (2004). "[Construction of full-length complementary DNA of hepatitis C virus genome from an HCV infected patient]." Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 18(2): 122-6.
Yang, C. and Y. H. Xiao, et al. (2004). "[A study on the clinical and pathological efficacy of lamivudine in the treatment of chronic hepatitis B]." Zhonghua Gan Zang Bing Za Zhi 12(6): 364-7.
Moradpour, D. and M. J. Evans, et al. (2004). "Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes." J Virol 78(14): 7400-9.
Wang, X. and Z. H. Yuan, et al. (2004). "Gene expression profiles in an hepatitis B virus transfected hepatoblastoma cell line and differentially regulated gene expression by interferon-alpha." World J Gastroenterol 10(12): 1740-5.
Xiong, W. and X. Wang, et al. (2004). "Interferon-inducible MyD88 protein inhibits hepatitis B virus replication." Virology 319(2): 306-14.
Xiong, W. and X. Wang, et al. (2003). "Analysis of gene expression in hepatitis B virus transfected cell line induced by interferon." Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35(12): 1053-60.
Mao, H. X. and S. Y. Lan, et al. (2003). "Establishment of a cell-based assay system for hepatitis C virus serine protease and its primary applications." World J Gastroenterol 9(11): 2474-9.
Lan, S. and H. Wang, et al. (2003). "Direct interaction between alpha-actinin and hepatitis C virus NS5B." FEBS Lett 554(3): 289-94.
Zhou, X. and L. Zheng, et al. (2003). "T helper 2 immunity to hepatitis B surface antigen primed by gene-gun-mediated DNA vaccination can be shifted towards T helper 1 immunity by codelivery of CpG motif-containing oligodeoxynucleotides." Scand J Immunol 58(3): 350-7.
Hu, Y. and M. Tang, et al. (2002). "[Association between NS5A gene sequence and response to interferon therapy in chronic hepatitis C patients in Shanghai]." Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 16(2): 114-8.
Wu, L. and Z. H. Yuan, et al. (2001). "Comparing the immunogenicity of hepatitis B virus S gene variants by DNA immunization." Viral Immunol 14(4): 359-67.
Lin, X. and Z. H. Yuan, et al. (2001). "A single amino acid in the reverse transcriptase domain of hepatitis B virus affects virus replication efficiency." J Virol 75(23): 11827-33.
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