Don Ganem，加州大学——HBV相关实验室及人物介绍系列

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Don Ganem，加州大学——HBV相关实验室及人物介绍系列

Don Ganem，加州大学，美国

Tropberger, P. and A. Mercier, et al. (2015). "Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation." Proc Natl Acad Sci U S A 112(42): E5715-24.
Ganem, D. and A. M. Prince (2004). "Hepatitis B virus infection--natural history and clinical consequences." N Engl J Med 350(11): 1118-29.
Baron JL and L. Gardiner, et al. (2002). "Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection." Immunity 16(4): 583-94.
Liu, Y. T. and R. Brazas, et al. (2001). "Efficient hepatitis delta virus RNA replication in avian cells requires a permissive factor(s) from mammalian cells." J Virol 75(16): 7489-93.
Wang, D. and J. Pearlberg, et al. (2001). "Deleterious effects of hepatitis delta virus replication on host cell proliferation." J Virol 75(8): 3600-4.
Bell, P. and R. Brazas, et al. (2000). "Hepatitis delta virus replication generates complexes of large hepatitis delta antigen and antigenomic RNA that affiliate with and alter nuclear domain 10." J Virol 74(11): 5329-36.
Wei, Y. and D. Ganem (1998). "Activation of heterologous gene expression by the large isoform of hepatitis delta antigen." J Virol 72(3): 2089-96.
Ganem, D. (1998). "Towards a rational therapy for hepatitis B." J Clin Invest 102(5): 867-8.
Wei, Y. and B. Tennant, et al. (1998). "In vivo effects of mutations in woodchuck hepatitis virus enhancer II." J Virol 72(8): 6608-13.
Eng, F. J. and E. G. Novikova, et al. (1998). "gp180, a protein that binds duck hepatitis B virus particles, has metallocarboxypeptidase D-like enzymatic activity." J Biol Chem 273(14): 8382-8.
Wei, Y. and B. Tennant, et al. (1998). "In vivo effects of mutations in woodchuck hepatitis virus enhancer II." J Virol 72(8): 6608-13.
Perri, S. and D. Ganem (1997). "Effects of mutations within and adjacent to the terminal repeats of hepatitis B virus pregenomic RNA on viral DNA synthesis." J Virol 71(11): 8448-55.
Brazas, R. and D. Ganem (1996). "A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution." Science 274(5284): 90-4.
Perri, S. and D. Ganem (1996). "A host factor that binds near the termini of hepatitis B virus pregenomic RNA." J Virol 70(10): 6803-9.
Wei, Y. and J. E. Tavis, et al. (1996). "Relationship between viral DNA synthesis and virion envelopment in hepatitis B viruses." J Virol 70(9): 6455-8.
Tavis, J. E. and D. Ganem (1996). "Evidence for activation of the hepatitis B virus polymerase by binding of its RNA template." J Virol 70(9): 5741-50.
Ueda, K. and Y. Wei, et al. (1996). "Cellular factors controlling the activity of woodchuck hepatitis virus enhancer II." J Virol 70(7): 4714-23.
Chang, C. and R. C. Hirsch, et al. (1995). "Sequences in the preC region of duck hepatitis B virus affect pregenomic RNA accumulation." Virology 207(2): 549-54.
Ishikawa, T. and D. Ganem (1995). "The pre-S domain of the large viral envelope protein determines host range in avian hepatitis B viruses." Proc Natl Acad Sci U S A 92(14): 6259-63.
Tavis, J. E. and D. Ganem (1995). "RNA sequences controlling the initiation and transfer of duck hepatitis B virus minus-strand DNA." J Virol 69(7): 4283-91.
Kuroki, K. and F. Eng, et al. (1995). "gp180, a host cell glycoprotein that binds duck hepatitis B virus particles, is encoded by a member of the carboxypeptidase gene family." J Biol Chem 270(25): 15022-8.
Ostapchuk, P. and P. Hearing, et al. (1994). "A dramatic shift in the transmembrane topology of a viral envelope glycoprotein accompanies hepatitis B viral morphogenesis." EMBO J 13(5): 1048-57.
Pollack, J. R. and D. Ganem (1994). "Site-specific RNA binding by a hepatitis B virus reverse transcriptase initiates  two distinct reactions: RNA packaging and DNA synthesis." J Virol 68(9): 5579-87.
Ishikawa, T. and K. Kuroki, et al. (1994). "Analysis of the binding of a host cell surface glycoprotein to the preS protein of duck hepatitis B virus." Virology 202(2): 1061-4.
Lingappa, J. R. and R. L. Martin, et al. (1994). "A eukaryotic cytosolic chaperonin is associated with a high molecular weight intermediate in the assembly of hepatitis B virus capsid, a multimeric particle." J Cell Biol 125(1): 99-111.
Ganem, D. and J. R. Pollack, et al. (1994). "Hepatitis B virus reverse transcriptase and its many roles in hepadnaviral genomic replication." Infect Agents Dis 3(2-3): 85-93.
Kuroki, K. and R. Cheung, et al. (1994). "A cell surface protein that binds avian hepatitis B virus particles." J Virol 68(4): 2091-6.
Pollack, J. R. and D. Ganem (1993). "An RNA stem-loop structure directs hepatitis B virus genomic RNA encapsidation." J Virol 67(6): 3254-63.
Hansen, L. J. and B. C. Tennant, et al. (1993). "Differential activation of myc gene family members in hepatic carcinogenesis by closely related hepatitis B viruses." Mol Cell Biol 13(1): 659-67.
Tavis, J. E. and D. Ganem (1993). "Expression of functional hepatitis B virus polymerase in yeast reveals it to be the sole viral protein required for correct initiation of reverse transcription." Proc Natl Acad Sci U S A 90(9): 4107-11.
Lavine, J. E. and D. Ganem (1993). "Inhibition of duck hepatitis B virus replication by interferon-gamma." J Med Virol 40(1): 59-64.
Cherrington, J. and R. Russnak, et al. (1992). "Upstream sequences and cap proximity in the regulation of polyadenylation in ground squirrel hepatitis virus." J Virol 66(12): 7589-96.
Loeb, D. D. and R. C. Hirsch, et al. (1991). "Sequence-independent RNA cleavages generate the primers for plus strand DNA synthesis in hepatitis B viruses: implications for other reverse transcribing elements." EMBO J 10(11): 3533-40.
Bruss, V. and D. Ganem (1991). "Mutational analysis of hepatitis B surface antigen particle assembly and secretion." J Virol 65(7): 3813-20.
Hirsch, R. C. and D. D. Loeb, et al. (1991). "cis-acting sequences required for encapsidation of duck hepatitis B virus pregenomic RNA." J Virol 65(6): 3309-16.
Seeger, C. and B. Baldwin, et al. (1991). "Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus in a common host." J Virol 65(4): 1673-9.
Macrae, D. R. and V. Bruss, et al. (1991). "Myristylation of a duck hepatitis B virus envelope protein is essential for infectivity but not for virus assembly." Virology 181(1): 359-63.
Bruss, V. and D. Ganem (1991). "The role of envelope proteins in hepatitis B virus assembly." Proc Natl Acad Sci U S A 88(3): 1059-63.
Lavine, J. E. and J. R. Lake, et al. (1991). "Persistent hepatitis B virus following interferon alfa therapy and liver transplantation." Gastroenterology 100(1): 263-7.
Chang, L. J. and R. C. Hirsch, et al. (1990). "Effects of insertional and point mutations on the functions of the duck hepatitis B virus polymerase." J Virol 64(11): 5553-8.
Kuroki, K. and M. Floreani, et al. (1990). "Epitope mapping of the PreS1 domain of the hepatitis B virus large surface protein." Virology 176(2): 620-4.
Russnak, R. and D. Ganem (1990). "Sequences 5' to the polyadenylation signal mediate differential poly(A) site use  in hepatitis B viruses." Genes Dev 4(5): 764-76.
Hirsch, R. C. and J. E. Lavine, et al. (1990). "Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as wel as for reverse transcription." Nature 344(6266): 552-5.
Eble, B. E. and V. R. Lingappa, et al. (1990). "The N-terminal (pre-S2) domain of a hepatitis B virus surface glycoprotein is translocated across membranes by downstream signal sequences." J Virol 64(3): 1414-9.
Kuroki, K. and R. Russnak, et al. (1989). "Novel N-terminal amino acid sequence required for retention of a hepatitis B virus glycoprotein in the endoplasmic reticulum." Mol Cell Biol 9(10): 4459-66.
Colgrove, R. and G. Simon, et al. (1989). "Transcriptional activation of homologous and heterologous genes by the hepatitis  B virus X gene product in cells permissive for viral replication." J Virol 63(9): 4019-26.
Chang, L. J. and J. Dienstag, et al. (1989). "Detection of antibodies against hepatitis B virus polymerase antigen in hepatitis B virus-infected patients." Hepatology 10(3): 332-5.
Chang, L. J. and P. Pryciak, et al. (1989). "Biosynthesis of the reverse transcriptase of hepatitis B viruses involves de novo translational initiation not ribosomal frameshifting." Nature 337(6205): 364-8.
Simon, K. and V. R. Lingappa, et al. (1988). "Secreted hepatitis B surface antigen polypeptides are derived from a transmembrane precursor." J Cell Biol 107(6 Pt 1): 2163-8.
Hirsch, R. and R. Colgrove, et al. (1988). "Replication of duck hepatitis B virus in two differentiated human hepatoma cell lines after transfection with cloned viral DNA." Virology 167(1): 136-42.
Simon, K. and V. R. Lingappa, et al. (1988). "A block to the intracellular transport and assembly of hepatitis B surface antigen polypeptides in Xenopus oocytes." Virology 166(1): 76-81.
Persing, D. H. and H. E. Varmus, et al. (1987). "The preS1 protein of hepatitis B virus is acylated at its amino terminus with myristic acid." J Virol 61(5): 1672-7.
Ganem, D. and H. E. Varmus (1987). "The molecular biology of the hepatitis B viruses." Annu Rev Biochem 56: 651-93.
Enders, G. H. and D. Ganem, et al. (1987). "5'-terminal sequences influence the segregation of ground squirrel hepatitis virus RNAs into polyribosomes and viral core particles." J Virol 61(1): 35-41.
Eble, B. E. and D. R. MacRae, et al. (1987). "Multiple topogenic sequences determine the transmembrane orientation of the hepatitis B surface antigen." Mol Cell Biol 7(10): 3591-601.
Chang, C. and G. Enders, et al. (1987). "Expression of the precore region of an avian hepatitis B virus is not required for viral replication." J Virol 61(10): 3322-5.
Seeger, C. and P. L. Marion, et al. (1987). "In vitro recombinants of ground squirrel and woodchuck hepatitis viral DNAs produce infectious virus in squirrels." J Virol 61(10): 3241-7.
Persing, D. H. and H. E. Varmus, et al. (1986). "Inhibition of secretion of hepatitis B surface antigen by a related presurface polypeptide." Science 234(4782): 1388-91.
Persing, D. H. and H. E. Varmus, et al. (1986). "Antibodies to pre-S and X determinants arise during natural infection with ground squirrel hepatitis virus." J Virol 60(1): 177-84.
Eble, B. E. and V. R. Lingappa, et al. (1986). "Hepatitis B surface antigen: an unusual secreted protein initially synthesized as a transmembrane polypeptide." Mol Cell Biol 6(5): 1454-63.
Seeger, C. and D. Ganem, et al. (1986). "Biochemical and genetic evidence for the hepatitis B virus replication strategy." Science 232(4749): 477-84.
Enders, G. H. and D. Ganem, et al. (1985). "Mapping the major transcripts of ground squirrel hepatitis virus: the presumptive template for reverse transcriptase is terminally redundant." Cell 42(1): 297-308.
Trueba, D. and M. Phelan, et al. (1985). "Transmission of ground squirrel hepatitis virus to homologous and heterologous hosts." Hepatology 5(3): 435-9.
Persing, D. H. and H. E. Varmus, et al. (1985). "A frameshift mutation in the pre-S region of the human hepatitis B virus genome allows production of surface antigen particles but eliminates binding to polymerized albumin." Proc Natl Acad Sci U S A 82(10): 3440-4.
Seeger, C. and D. Ganem, et al. (1984). "The cloned genome of ground squirrel hepatitis virus is infectious in the animal." Proc Natl Acad Sci U S A 81(18): 5849-52.
Seeger, C. and D. Ganem, et al. (1984). "Nucleotide sequence of an infectious molecularly cloned genome of ground squirrel hepatitis virus." J Virol 51(2): 367-75.
Standring, D. N. and W. J. Rutter, et al. (1984). "Transcription of the hepatitis B surface antigen gene in cultured murine cells initiates within the presurface region." J Virol 50(2): 563-71.
Weiser, B. and D. Ganem, et al. (1983). "Closed circular viral DNA and asymmetrical heterogeneous forms in livers from animals infected with ground squirrel hepatitis virus." J Virol 48(1): 1-9.
Ganem, D. and G. N. Vyas (1983). "Laboratory diagnosis of viral hepatitis." Geriatrics 38(3): 97-103, 107-8.
Ganem, D. and B. Weiser, et al. (1982). "Biological characterization of acute infection with ground squirrel hepatitis virus." J Virol 44(1): 366-73.
Ganem, D. and L. Greenbaum, et al. (1982). "Virion DNA of ground squirrel hepatitis virus: structural analysis and molecular  cloning." J Virol 44(1): 374-83.
Ganem, D. (1982). "Persistent infection of humans with hepatitis B virus: mechanisms and consequences." Rev Infect Dis 4(5): 1026-47.