William S Mason--发现HBV逆转录过程的大牛!

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楼主：Davay
William S Mason, PhD
Professor


Research Interests

Hepatitis B and C viruses produce chronic infections of the liver which may lead to long term disease and cancer. It has been estimated that 1-5% of the US population is now infected with hepatitis C virus (HCV), and hepatitis B virus (HBV) infection is also common. Worldwide, infection by these viruses are the major cause of heptocellular carcinoma. The overall goals of our research are to characterize how these viruses replicate, their interactions with the infected host, the steps which lead to cell transformation and tumor outgrowth, and the effects of antiviral therapy on the long-term consequences of infection.


Research Staff

Haitao Guo, PhD Postdoctoral Fellow
Chunxiao Xu, PhD Postdoctoral Fellow
Carol E Aldrich Scientific Assistant
Jeffry Saputelli Research Technician
Nina DiPrimio Student Assistant

Carnegie-Mellon University, Pittsburgh, PA

Christine Hazel Student Assistant

St. Joseph's University, Philadelphia, PA

Recent Publications

In Press

Mason, W.S., Jilbert, A.R. Hepatitis B Virus: An Unresolved Problem. Proceedings of the 11th International Symposium on Viral Hepatitis and Liver Disease (in press).

2004

Summers, J., Mason, W.S. Residual integrated viral DNA after hepadnavirus clearance by nucleoside analog therapy. Proc. Natl. Acad. Sci. USA 101:638-640, 2004.

2003

Summers, J., Jilbert, A.R., Yang, W., Aldrich, C.E., Saputelli, J., Litwin, S., Toll, E., Mason, W.S. Hepatocyte turnover during resolution of a transient hepadnaviral infection. Proc. Natl. Acad. Sci. USA 100:11652-11659, 2003.

2002

Evans, A.A., O'Connell, A.P., Mason, W.S., M'boup, S., Shen, F.-M., London, W.T. Heterogeneity of the pre-C/C region of hepatitis B virus (HBV) in chronic carriers from China and West Africa. In Viral Hepatitis and Liver Disease, edited by H. Margolis. International Medical Press Ltd., London, pp. 365-376, 2002.

Jilbert, A.R., Mason, W.S. Hepatitis B Virus. In Encyclopedia of Life Sciences. Macmillan Publishers Ltd., Nature Publishing Group. www.els.net. 2002.

Mason, W.S., Litwin, S. Viral pathogenesis. In HBV Human Virus Guide, edited by S. Locarnini, C.L. Lai. International Medical Press, London, pp. 99-113, 2002.

Yamamoto, T., Litwin, S., Zhou, T., Zhu, Y. Condreay, L., Furman, P., Mason, W.S. Mutations of the WHV polymerase gene that confer resistance to lamivudine and L-FMAU. J. Virol. 76:1213-1223, 2002.

2001

Barrasa, M.I., Guo, J.-T., Saputelli, J., Mason, W.S., Seeger, C. Toward understanding the mechanism for uncoating in hepadnaviruses: Identification and genetic characterization of a serine/threonine-proline kinase recognition site on viral capsid proteins. J. Virol. 75:2024-2028, 2001.

Zhu, Y., Yamamoto, T., Cullen, J., Saputelli, J., Aldrich, C.E., Darren S. Miller, Litwin, S., Furman, P.A., Jilbert, A.R., and Mason, W.S. Kinetics of hepadnavirus loss from the liver during inhibition of viral DNA synthesis. J. Virol., 75: 311-322, 2001.



http://www.fccc.edu/research/pid/mason/