猪圆环病毒3型感染回顾性研究

xiaolinlhy

     猪圆环病毒3型（PVC3）是一种能够导致猪皮疹、肾病综合征、繁殖障碍、呼吸系统疾病和消化系统炎症的一种病毒。虽然第一次鉴定到该病毒是在2015年，但在美国其最早出现的病例可以追溯到2009年。在中国，PCV3感染首次检测到是在2015年，但在2015年之前几乎没有关于PCV3发生和流行的信息。
近日，中国的科学家们通过检测分析200份来自国内20个省份，五个自治区和四个直辖市，时间跨度从1990年到1999年的猪临床样本，发现具有6.5%的临床样本（分别来自8个省份和一个自治区）为PCV3阳性样本，且其最早的感染病例可以追溯到1996年。该研究成果已发表在Transboundary and EmergingDiseases杂志上，题为“Retropective study of porcinecircovirus 3 infection in China”。该研究进一步解析了PVC3早期在中国的流行情况，同时，研究还发现早期的PVC3流行毒株与当前的流行毒株基因组差异不大，说明PVC3基因遗传稳定高。
原文摘要
PCV3 is an emerging swine virus associated with porcine dermatitis and nephropathy syndrome (PDNS), reproductive failure, respiratory diseases and systematic inflammation. Although first identified in 2015, the earliest case has been traced back to 2009 in the United States. In China, PCV3 infection was first detected in 2015, but little information has been available about its occurrence and prevalence there before 2015. In this study, 200 porcine clinical samples collected from 20 provinces, five autonomous regions and four municipalities between 1990 and 1999 were analysed for PCV3 infection by PCR. Results showed that 6.5% of the porcine samples collected from eight provinces and one autonomous region were PCV3 positive, with the earliest cases occurring in 1996. Nucleotide sequence analysis showed that PCV3 strains obtained in this study shared 96.6%-99.7% and 97.1%-99.4% sequence identity at the ORF2 gene and genome levels with all available reference strains from China and other countries, indicating the high genetic stability of PCV3 over the past 20 years.
原文链接：http://onlinelibrary.wiley.com/doi/10.1111/tbed.12853/abstract

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