Viral Oncology: Basic Science and Clinical Applications

cao1976

Description
A comprehensive look at the latest research findings and clinical applications of oncogenic viruses
Written by a panel of academic experts, Viral Oncology is the first self-contained and comprehensive book to present both scientific and clinical information on viruses linked to some of the most important human cancers. Readers can turn to this book for the most in-depth and up-to-date coverage of: HPV-associated cancers; molecular events associated with HPV-induced human cancer; the role of the HPV E6 oncoprotein in malignant progression; virus association with brain tumors; involvement of the polyomavirus JCV in colorectal cancer; possibleassociation of BKV with prostate cancer; oncogenic transformation bypolyomavirus large T antigen; SV40 and human cancer; SV40 and mesothelioma; molecular immunology of hepatitis B–associated viral cancer; hepatitis B vaccine and hepatocellular carcinoma; pathogenesis of acute and chronic hepatitis Cvirus infection; molecular mechanisms of hepatitis C virus-induced cellulartransformation; clinical aspects of HTLV-1 associated cancer; oncogenic potential of the HTLV-1 tax protein; HIV-associated malignancy; HIV-related lymphoma; biology and epidemiology of HHV-8; the role of KSHV in pathogenesis of Kaposi'ssarcoma; molecular pathobiology of EBV infection; and EBV as a pathogen.

Several chapters are devoted to the basic science of oncogenic viruses for thestudy of their pathogenesis, drug development, and employment of viral vectorsfor vaccine and gene therapy. The book also includes complementary clinically based chapters describing natural courses and treatments. Additionally, bonusclinical materials are embedded within chapters and an easy-to-use indexcompletes the book.

Viral Oncology is an essential resource for clinical and research oncologists in medical facilities and biological research laboratories; clinicians and scientists working in related biomedical areas; medical students working toward a first or higher degree in the life sciences and other biomedical fields; and pharmaceutical scientists and developers.

Table of Contents
Foreword vii

Preface xi

Contributors xiii

1 HUMAN PAPILLOMAVIRUS-ASSOCIATED CANCERS 1
Rachel A. Katzenellenbogen and Denise A. Galloway

2 MOLECULAR EVENTS ASSOCIATED WITH HUMAN PAPILLOMAVIRUS-INDUCED HUMAN CANCERS 23
Amy Baldwin and Karl Münger

3 THE ROLE OF THE HUMAN PAPILLOMAVIRUS E6 ONCOPROTEIN IN MALIGNANT PROGRESSION 57
Miranda Thomas, David Pim, and Lawrence Banks

4 JC VIRUS ASSOCIATION WITH BRAIN TUMORS: THE ROLE OF T ANTIGEN AND INSULIN-LIKE GROWTH FACTOR 1 IN DNA REPAIR FIDELITY 89
Krzysztof Reiss, Kamel Khalili, and Luis Del Valle

5 INVOLVEMENT OF THE POLYOMAVIRUS, JC VIRUS, IN COLORECTAL CANCER 113
C. Richard Boland, Luigi Ricciardiello, and Ajay Goel

6 POSSIBLE ASSOCIATION OF BK VIRUS WITH PROSTATE CANCER 129
Michael J. Imperiale and Dweepanita Das

7 ONCOGENIC TRANSFORMATION BY POLYOMAVIRUS LARGE T ANTIGEN 149
Abhilasha V. Rathi and James M. Pipas

8 SIMIAN VIRUS 40, HUMAN INFECTIONS, AND CANCER: EMERGING CONCEPTS AND CAUSALITY CONSIDERATIONS 165
Janet S. Butel

9 SIMIAN VIRUS 40 AND MESOTHELIOMA 191
Natalya Baranova and Michele Carbone

10 MOLECULAR IMMUNOBIOLOGY OF HEPATITIS B-ASSOCIATED VIRAL CANCER 211
Timothy M. Block and Anand S. Mehta

11 HEPATITIS B VACCINE AND HEPATOCELLULAR CARCINOMA 225
Mei-Hwei Chang and Ding-Shinn Chen

12 PATHOGENESIS OF ACUTE AND CHRONIC HEPATITIS C VIRUS INFECTION 243
Mark A. Feitelson, Helena M.G.P.V. Reis, Jingbo Pan, and Bill Sun

13 MOLECULAR MECHANISMS OF HEPATITIS C VIRUS-INDUCED CELLULAR TRANSFORMATION 267
Donna Sir and Jing-Hsiung James Ou

14 CLINICAL ASPECTS OF HTLV-1-ASSOCIATED CANCER 279
Masao Matsuoka

15 ONCOGENIC POTENTIAL OF THE HTLV-1 TAX PROTEIN 295
Susan J. Marriott

16 HIV-1-ASSOCIATED MALIGNANCY: BASIC AND CLINICAL ASPECTS 317
Melissa Agsalda and Bruce Shiramizu

17 HIV-RELATED LYMPHOMA 337
Giulia De Falco, Cristiana Bellan, Stefano Lazzi, and Lorenzo Leoncini

18 BIOLOGY AND EPIDEMIOLOGY OF HHV-8 351
Veenu Minhas and Charles Wood

19 THE ROLE OF KSHV IN PATHOGENESIS OF KAPOSI’S SARCOMA 377
Gary S. Hayward, Donald J. Alcendor, and Ravit Arav-Boger

20 MOLECULAR PATHOBIOLOGY OF EBV INFECTION 409
Joseph S. Pagano

21 EPSTEIN–BARR VIRUS AS A PATHOGEN 425
Wasim A. Dar and Bill Sugden

Index 453
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